Amantadine and Rimantadine Inhibit Hepatitis A Virus Replication through the Induction of Autophagy.


Journal

Journal of virology
ISSN: 1098-5514
Titre abrégé: J Virol
Pays: United States
ID NLM: 0113724

Informations de publication

Date de publication:
28 09 2022
Historique:
pubmed: 31 8 2022
medline: 1 10 2022
entrez: 30 8 2022
Statut: ppublish

Résumé

Hepatitis A virus (HAV) infection is a major cause of acute viral hepatitis worldwide. Furthermore, HAV causes acute liver failure or acute-on-chronic liver failure. However, no potent anti-HAV drugs are currently available in the clinical situations. There have been some reports that amantadine, a broad-spectrum antiviral, suppresses HAV replication

Identifiants

pubmed: 36040176
doi: 10.1128/jvi.00646-22
pmc: PMC9517723
doi:

Substances chimiques

Antiviral Agents 0
Hepatitis A Antibodies 0
Rimantadine 0T2EF4JQTU
Amantadine BF4C9Z1J53

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

e0064622

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Auteurs

Reina Sasaki-Tanaka (R)

Division of Gastroenterology and Hepatology, Department of Medicine, Nihon University School of Medicine, Tokyo, Japan.

Toshikatsu Shibata (T)

Division of Gastroenterology and Hepatology, Department of Medicine, Nihon University School of Medicine, Tokyo, Japan.

Mitsuhiko Moriyama (M)

Division of Gastroenterology and Hepatology, Department of Medicine, Nihon University School of Medicine, Tokyo, Japan.

Hiroaki Okamoto (H)

Division of Virology, Department of Infection and Immunity, Jichi Medical University School of Medicine, Shimotsuke, Tochigi, Japan.

Hirofumi Kogure (H)

Division of Gastroenterology and Hepatology, Department of Medicine, Nihon University School of Medicine, Tokyo, Japan.

Tatsuo Kanda (T)

Division of Gastroenterology and Hepatology, Department of Medicine, Nihon University School of Medicine, Tokyo, Japan.

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Classifications MeSH