A locus coeruleus-dorsal CA1 dopaminergic circuit modulates memory linking.
contextual memory
dopamine
dorsal hippocampus
ensembles
locus coeruleus
median raphe
memory linking
neuromodulation
neuronal excitability
Journal
Neuron
ISSN: 1097-4199
Titre abrégé: Neuron
Pays: United States
ID NLM: 8809320
Informations de publication
Date de publication:
19 10 2022
19 10 2022
Historique:
received:
30
11
2021
revised:
07
01
2022
accepted:
31
07
2022
pubmed:
31
8
2022
medline:
25
10
2022
entrez:
30
8
2022
Statut:
ppublish
Résumé
Individual memories are often linked so that the recall of one triggers the recall of another. For example, contextual memories acquired close in time can be linked, and this is known to depend on a temporary increase in excitability that drives the overlap between dorsal CA1 (dCA1) hippocampal ensembles that encode the linked memories. Here, we show that locus coeruleus (LC) cells projecting to dCA1 have a key permissive role in contextual memory linking, without affecting contextual memory formation, and that this effect is mediated by dopamine. Additionally, we found that LC-to-dCA1-projecting neurons modulate the excitability of dCA1 neurons and the extent of overlap between dCA1 memory ensembles as well as the stability of coactivity patterns within these ensembles. This discovery of a neuromodulatory system that specifically affects memory linking without affecting memory formation reveals a fundamental separation between the brain mechanisms modulating these two distinct processes.
Identifiants
pubmed: 36041433
pii: S0896-6273(22)00707-3
doi: 10.1016/j.neuron.2022.08.001
pmc: PMC10508214
mid: NIHMS1931205
pii:
doi:
Substances chimiques
Dopamine
VTD58H1Z2X
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
3374-3388.e8Subventions
Organisme : NIA NIH HHS
ID : R37 AG013622
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH124867
Pays : United States
Organisme : NINDS NIH HHS
ID : U01 NS094286
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS106969
Pays : United States
Organisme : NIA NIH HHS
ID : RF1 AG013622
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH113071
Pays : United States
Commentaires et corrections
Type : CommentIn
Informations de copyright
Copyright © 2022 Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of interests The authors declare no competing interests.
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