Sterols in asthma.

Asthma Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors / pharmacology Sterols
Th17 asthma neutrophilic severe statin sterol

Journal

Trends in immunology
ISSN: 1471-4981
Titre abrégé: Trends Immunol
Pays: England
ID NLM: 100966032

Informations de publication

Date de publication:
10 2022
Historique:
received: 17 06 2022
revised: 03 08 2022
accepted: 05 08 2022
pubmed: 31 8 2022
medline: 28 9 2022
entrez: 30 8 2022
Statut: ppublish

Résumé

While sterols regulate immune processes key to the pathogenesis of asthma, inhibition of sterols with statin drugs has shown conflicting results in human asthma. Here, a novel understanding of the impact of sterols on type 17 immune responses and asthma lead us to hypothesize that sterols and statins may be relevant to severe asthma endotypes with neutrophil infiltration.

Identifiants

DOI: 10.1016/j.it.2022.08.003 PMID: 36041950 PMC: PMC9513744
pubmed: 36041950
pii: S1471-4906(22)00163-6
doi: 10.1016/j.it.2022.08.003
pmc: PMC9513744
mid: NIHMS1832990
pii:
doi:

Substances chimiques

Hydroxymethylglutaryl-CoA Reductase Inhibitors 0
Sterols 0

Types de publication

Journal Article Review Research Support, Non-U.S. Gov't Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

792-799

Subventions

Organisme : NHLBI NIH HHS
ID : R01 HL155095
Pays : United States
Organisme : NIAID NIH HHS
ID : R03 AI151769
Pays : United States
Organisme : NHLBI NIH HHS
ID : R00 HL131682
Pays : United States
Organisme : NIAID NIH HHS
ID : R21 AI127354
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI121405
Pays : United States

Informations de copyright

Copyright © 2022 Elsevier Ltd. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of interests The authors have no interests to declare.

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Auteurs

Mireia Guerau-de-Arellano (M)

School of Health and Rehabilitation Sciences, Division of Medical Laboratory Science, College of Medicine, Wexner Medical Center, The Ohio State University, Columbus, OH, USA; Institute for Behavioral Medicine Research, The Ohio State University, Columbus, OH, USA; Department of Microbial Infection and Immunity, The Ohio State University, Columbus, OH, USA; Department of Neuroscience, The Ohio State University, Columbus, OH, USA. Electronic address: mireia.guerau@osumc.edu.

Rodney D Britt (RD)

Center for Perinatal Research, The Abigail Wexner Research Institute at Nationwide Children's Hospital and Department of Pediatrics, The Ohio State University, Columbus, OH, USA.

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Classifications MeSH

questionsmedicales.fr › Maladies du système immunitaire › Hypersensibilité › Hypersensibilité immédiate › Hypersensibilité respiratoire › Asthme › Sterols in asthma.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Sterols in asthma.
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Agents régulateurs du métabolisme des lipides › Hypolipémiants › Anticholestérolémiants › Inhibiteurs de l'hydroxyméthylglutaryl-CoA réductase › Sterols in asthma.
questionsmedicales.fr › Lipides › Lipides membranaires › Stérols › Sterols in asthma.