Elevated KIR expression and diminished intensity of CD7 on NK cell subsets among treatment naïve HIV infected Ethiopians.


Journal

Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288

Informations de publication

Date de publication:
30 08 2022
Historique:
received: 30 04 2022
accepted: 10 08 2022
entrez: 30 8 2022
pubmed: 31 8 2022
medline: 3 9 2022
Statut: epublish

Résumé

Natural killer (NK) cells are crucial effector cells of the innate immune response to viral infections, including HIV, through cytolytic activity and the production of cytokines with anti-HIV activities. We recruited 15 treatment naïve HIV patients and 16 healthy controls (HC) to assess NK cell subsets or expression of multiple markers by flow cytometry. The frequency of circulating CD56

Identifiants

pubmed: 36042218
doi: 10.1038/s41598-022-18413-3
pii: 10.1038/s41598-022-18413-3
pmc: PMC9427747
doi:

Substances chimiques

CD56 Antigen 0
Receptors, IgG 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

14747

Informations de copyright

© 2022. The Author(s).

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Auteurs

Henok Andualem (H)

Department of Medical Laboratory Science, College of Medicine and Health Sciences, Debre Tabor University, P.O. Box 272, Debre Tabor, Ethiopia. henokyaa@yahoo.com.

Mulualem Lemma (M)

Department of Immunology and Molecular Biology, School of Medical Laboratory Science, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.

Amare Keflie (A)

Department of Immunology and Molecular Biology, School of Medical Laboratory Science, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.

Meseret Workeneh (M)

Department of Immunology and Molecular Biology, School of Medical Laboratory Science, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.

Birhanu Ayelign (B)

Department of Immunology and Molecular Biology, School of Medical Laboratory Science, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.

Yayehyirad Tassachew (Y)

School of Medical Laboratory Sciences, College of Medicine and Health Sciences, Hawassa University, Hawassa, Ethiopia.

Lidya Hailu (L)

Department of Medical Laboratory Science, College of Medicine and Health Sciences, Debre Tabor University, P.O. Box 272, Debre Tabor, Ethiopia.
Department of Chemistry, College of Natural and Computational Science, Debre Tabor University, Debre Tabor, Ethiopia.

Alene Geteneh (A)

Department of Medical Laboratory Science, College of Health Sciences, Woldia University, Woldia, Ethiopia.

Adane Mihret (A)

Armauer Hansen Research Institute, Addis Ababa, Ethiopia.

Martha Zewdie (M)

Armauer Hansen Research Institute, Addis Ababa, Ethiopia.

Rawleigh Howe (R)

Armauer Hansen Research Institute, Addis Ababa, Ethiopia.

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