Release of VAMP5-positive extracellular vesicles by retinal Müller glia in vivo.
SNARE complex
exosomes
gliosis
microvillus
neuroglia
secretome
tetraspanin
vitreous body
Journal
Journal of extracellular vesicles
ISSN: 2001-3078
Titre abrégé: J Extracell Vesicles
Pays: United States
ID NLM: 101610479
Informations de publication
Date de publication:
09 2022
09 2022
Historique:
revised:
25
06
2022
received:
19
04
2022
accepted:
18
07
2022
entrez:
31
8
2022
pubmed:
1
9
2022
medline:
3
9
2022
Statut:
ppublish
Résumé
Cell-cell interactions in the central nervous system are based on the release of molecules mediating signal exchange and providing structural and trophic support through vesicular exocytosis and the formation of extracellular vesicles. The specific mechanisms employed by each cell type in the brain are incompletely understood. Here, we explored the means of communication used by Müller cells, a type of radial glial cells in the retina, which forms part of the central nervous system. Using immunohistochemical, electron microscopic, and molecular analyses, we provide evidence for the release of distinct extracellular vesicles from endfeet and microvilli of retinal Müller cells in adult mice in vivo. We identify VAMP5 as a Müller cell-specific SNARE component that is part of extracellular vesicles and responsive to ischemia, and we reveal differences between the secretomes of immunoaffinity-purified Müller cells and neurons in vitro. Our findings suggest extracellular vesicle-based communication as an important mediator of cellular interactions in the retina.
Identifiants
pubmed: 36043482
doi: 10.1002/jev2.12254
pmc: PMC9428896
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e12254Subventions
Organisme : Universite de Strasbourg
ID : UPR3212
Organisme : ProRetina Foundation Germany
ID : Pro-Re/Seed/Grosche.1-2014
Organisme : ProRetina Foundation Germany
ID : Pro-Re/Seed/Kaplan-Grosche.1-2019
Organisme : Centre National de la Recherche Scientifique
ID : UPR3212
Organisme : Deutsche Forschungsgemeinschaft
ID : GR 4403/1-1
Organisme : Deutsche Forschungsgemeinschaft
ID : GR 4403/5-1
Organisme : Deutsche Forschungsgemeinschaft
ID : GR 4403/7-1
Organisme : Deutsche Forschungsgemeinschaft
ID : HA 6014/5-1
Organisme : Agence Nationale de la Recherche
ID : GLIAVAMP
Informations de copyright
© 2022 The Authors. Journal of Extracellular Vesicles published by Wiley Periodicals, LLC on behalf of the International Society for Extracellular Vesicles.
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