UK Nutrition Research Partnership 'Hot Topic' workshop: Vitamin D-A multi-disciplinary approach to (1) elucidate its role in human health and (2) develop strategies to improve vitamin D status in the UK population.
multi-disciplinary approach
public health
strategies
vitamin D
Journal
Nutrition bulletin
ISSN: 1467-3010
Titre abrégé: Nutr Bull
Pays: England
ID NLM: 9315625
Informations de publication
Date de publication:
06 2022
06 2022
Historique:
received:
13
04
2022
accepted:
13
04
2022
entrez:
31
8
2022
pubmed:
1
9
2022
medline:
9
9
2022
Statut:
ppublish
Résumé
Vitamin D is truly unique-not a 'vital' amine in the true sense of the word, but rather a prohormone, which is produced in the skin during exposure to sunlight (UVB radiation at 290-315 nm) and which can also be obtained from food and from supplements. A high prevalence of low vitamin D status has been reported across the world in a wide range of population groups, and this includes communities living in low latitude areas despite the abundance of sunlight. It is accepted that vitamin D status is reflected by the level of the circulating metabolite 25-hydroxyvitamin D (25[OH]D), which is produced by hepatic hydroxylation of vitamin D, derived either from the skin from UV exposure or the gut from oral intake. Vitamin D has been associated with a wide range of health outcomes, but controversies remain as to their exact nature and extent and whether associations are in the causal pathway. In order to enable wider discussions on this nutrient, a 'Hot Topic' Vitamin D Workshop achieved funding from the UK Nutrition Research Partnership Medical Research Council call. The objectives of the workshop were (1) to elucidate the role of vitamin D in human health and (2) develop strategies to improve vitamin D status in the UK population. This paper provides a detailed resume of the discussions of the workshop; of the presentations and concomitant Q&As; and of identified areas for future research.
Substances chimiques
Vitamins
0
Vitamin D
1406-16-2
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
246-260Subventions
Organisme : Medical Research Council
ID : 4050769711
Pays : United Kingdom
Informations de copyright
© 2022 British Nutrition Foundation.
Références
Bishop, E., Ismailova, A., Dimeloe, S.K., Hewison, M. & White, J.H. (2020) Vitamin D and immune regulation: antibacterial, antiviral, anti-inflammatory. JBMR Plus, 5(1), e10405. https://doi.org/10.1002/jbm4.10405
Bouillon, R. (2016) Free or Total 25OHD as marker for vitamin D status? Journal of Bone and Mineral Research, 31(6), 1124-1127. https://doi.org/10.1002/jbmr.2871 PMID: 27172227.
Bouillon, R. (2017) Comparative analysis of nutritional guidelines for vitamin D. Nature Reviews Endocrinology, 13(8), 466-479. https://doi.org/10.1038/nrendo.2017.31
Butler-Laporte, G., Nakanishi, T., Mooser, V., Morrison, D.R., Abdullah, T., Adeleye, O. et al. (2021) Vitamin D and COVID-19 susceptibility and severity in the COVID-19 Host Genetics Initiative: A Mendelian randomization study. PLoS Medicine, 8(6), e1003605.
Buttriss, J.L. (2018) The Office for Strategic Coordination of Health Research (OSCHR) review of nutrition and health research: Window of opportunity. Nutrition Bulletin, 43(1), 79-84.
Buttriss, J.L. & Lanham-New, S.A. (2020) Is a vitamin D fortification strategy needed? Nutrition Bulletin, 45(2), 115-122.
Buttriss, J.L., Lanham-New, S.A., Steenson, S., Levy, L., Swan, G.E., Darling, A.L. et al. (2021) Implementation strategies for increasing vitamin D intake in the UK: current controversies and future perspectives: proceedings of the second rank prize funds forum on vitamin D. British Journal of Nutrition, 127(10), 1567-1587.
Cashman, K.D. (2018) Vitamin D requirements for the future-lessons learned and charting a path forward. Nutrients, 10(5), 533.
Cashman, K.D., Dowling, K.G., Škrabáková, Z., Gonzalez-Gross, M., Valtueña, J., De Henauw, S. et al. (2016) Vitamin D deficiency in Europe: pandemic? The American Journal of Clinical Nutrition, 103(4), 1033-1044. https://doi.org/10.3945/ajcn.115.120873
Cashman, K.D., Kiely, M.E., Andersen, R., Grønborg, I.M., Tetens, I., Tripkovic, L. et al. (2021) Individual participant data (IPD)-level meta-analysis of randomised controlled trials to estimate the dietary requirement for vitamin D in dark-skinned individuals residing at higher latitudes. European Journal of Nutrition, 61(2), 1015-1034.
Cashman, K.D., Ritz, C., Kiely, M. & Odin Collaborators. (2017) Improved dietary guidelines for vitamin D: application of individual participant data (IPD)-level meta-regression analyses. Nutrients, 9(5), 469.
Chambers E., Vukmanovic-Stejic M., & Turner CT (2021). Vitamin D3 replacement enhances antigen-specific immunity in older adults Immunotherapy Advances, 1(1), ltaa008. https://doi.org/10.1093/immadv/ltaa008
Davidson, J., Banerjee, A., Mathur, R., Ramsay, M., Smeeth, L., Walker, J. et al. (2021) Ethnic differences in the incidence of clinically diagnosed influenza: an England population-based cohort study 2008-2018. Wellcome Open Research, 10(6), 49. https://doi.org/10.12688/wellcomeopenres.16620.3
Davies, N.M., Holmes, M.V. & Davey Smith, G. (2018) Reading Mendelian randomisation studies: a guide, glossary, and checklist for clinicians. British Medical Journal, 362, k601.
Darling, A.L., Hart, K.H., Macdonald, H.M., Horton, K., Kang'ombe, A.R., Berry, J.L. et al. (2013) Vitamin D deficiency in UK south Asian women of childbearing age: a comparative longitudinal investigation with UK Caucasian women. Osteoporosis International, 24(2), 477-488.
Durrant, L., Bucca, G., Hesketh, A., Möller-Levet, C., Tripkovic, L., Wu, H. et al. (2022) Vitamins D2 and D3 have overlapping but different effects on human gene expression revealed through analysis of blood transcriptomes in a randomised double-blind placebo-controlled food-fortification trial. Frontiers in Immunology, 24. https://doi.org/10.3389/fimmu.2022.790444
Gibson-Moore, H. (2021) Vitamin D: what's new a year on from the COVID-19 outbreak? Nutrition Bulletin, 46(2), 195-205.
Hastie C.E., Mackay D.F., Ho F., Celis-Morales C.A., Katikireddi S.V., Niedzwiedz C.L., et al. (2020). Vitamin D concentrations and COVID-19 infection in UK Biobank. Diabetes & metabolic syndrome, 14(4), 561-565. https://doi.org/10.1016/j.dsx.2020.04.050
Holt, H., Talaei, M., Greenig, M., Zenner, D., Symons, J., Relton, C. et al. (2021) Risk factors for developing COVID-19: a population-based longitudinal study (COVIDENCE UK). Thorax. https://thorax.bmj.com/content/early/2021/11/02/thoraxjnl-2021-217487.citation-tools
Jolliffe, D.A., Camargo, C.A., Sluyter, J.D., Aglipay, M., Aloia, J.F., Ganmaa, D. et al. (2021) Vitamin D supplementation to prevent acute respiratory infections: a systematic review and meta-analysis of aggregate data from randomised controlled trials. The Lancet Diabetes & Endocrinology, 9(5), 276-292.
Jolliffe, D.A., Stefanidis, C. & Wang, Z. (2020) Vitamin D metabolism is dysregulated in asthma and chronic obstructive pulmonary disease. American Journal of Respiratory and Critical Care Medicine, 202(3), 371-382. doi:10.1164/rccm.201909-1867OC
Julies, P., Lynn, R.M., Pall, K., Leoni, M., Calder, A., Mughal, Z. et al. (2020) Nutritional rickets under 16 years: UK surveillance results. Archives of Disease in Childhood, 105(6), 587-592. https://doi.org/10.1136/archdischild-2019-317934
Lanham-New, S.A., Webb, A.R., Cashman, K.D., Buttriss, J.L., Fallowfield, J.L., Masud, T. et al. (2020) Vitamin D and SARS-CoV-2 virus/COVID-19 disease. BMJ Nutrition, Prevention & Health, 3(1), 106-110. https://doi.org/10.1136/bmjnph-2020-000089
Macdonald, H.M., Mavroeidi, A., Fraser, W.D., Darling, A.L., Black, A.J., Aucott, L. et al. (2011) Sunlight and dietary contributions to the seasonal vitamin D status of cohorts of healthy postmenopausal women living at northerly latitudes: a major cause for concern? Osteoporosis International, 22(9), 2461-2472.
Martineau, A.R., Jolliffe, D.A. & Hooper, R.L. (2017) Vitamin D supplementation to prevent acute respiratory tract infections: systematic review and meta-analysis of individual participant data. British Medical Journal, 356, i6583.
MRC & NIHR (Medical Research Council & National Institute of Health Research). (2017) Review of Nutrition and Human Health Research. Available from: https://www.mrc.ac.uk/documents/pdf/review-of-nutrition-and-human-health/. Accessed 10 May 2022.
Mokry, L.E., Ross, S., Ahmad, O.S., Forgetta, V., Smith, G.D., Leong, A. et al. (2015) Vitamin D and risk of multiple sclerosis: a mendelian randomization study. PLoS Medicine, 12(8), e1001866.
Mokry LE, Ross S, Timpson NJ, Sawcer S, Davey Smith G, Richards JB (2016) Obesity and multiple sclerosis: a mendelian randomization study. PLoS Medicine 13(6): e1002053. https://doi.org/10.1371/journal.pmed.1002053
Pairo-Castineira, E., Clohisey, S., Klaric, L., Bretherick, A.D., Rawlik, K., Pasko, D. et al. (2021) Genetic mechanisms of critical illness in COVID-19. Nature, 591(7848), 92-98.
PHE (Public Health England). (2020) Disparities in the risk and outcomes of COVID-19. Available from: https://assets.publishing.service.gov.uk/government/uploads/system/uploads/attachment_data/file/889861/disparities_review.pdf [Accessed 17 August 2021].
PHE (Public Health England). National Diet and Nutrition Survey Rolling programme Years 9 to 11 (2016/2017 to 2018/2019) (2020). Available from: https://www.gov.uk/government/statistics/ndns-results-from-years-9-to-11-2016-to-2017-and-2018-to-2019 [Accessed 10 May 2022].
Queen Mary University of London. (2022). Trial of Vitamin D to Reduce Risk and Severity of COVID-19 and Other Acute Respiratory Infections (CORONAVIT). Available at: https://clinicaltrials.gov/ct2/show/NCT04579640 [Accessed 10 May 2022].
SACN (Scientific Advisory Committee on Nutrition). (2016) Vitamin D and health. Available from: https://www.gov.uk/government/publications/sacn-vitamin-d-and-health-report [Accessed 10 May 2022].
SACN (Scientific Advisory Committee on Nutrition). (2020a) Rapid review: vitamin D and acute respiratory tract infections. Available from: https://assets.publishing.service.gov.uk/government/uploads/system/uploads/attachment_data/file/944108/SACN_June2020_VitaminD_AcuteRespiratoryTractInfections.pdf [Accessed 17 August 2021].
SACN (Scientific Advisory Committee on Nutrition). (2020b) Update of rapid review: Vitamin D and acute respiratory tract infections. Available from: https://assets.publishing.service.gov.uk/government/uploads/system/uploads/attachment_data/file/945179/SACN_December2020_VitaminD_AcuteRespiratoryTractInfections.pdf
Webb, A.R., Kazantzidis, A., Kift, R.C., Farrar, M.D., Wilkinson, J. & Rhodes, L.E. (2018a) Meeting vitamin D requirements in White Caucasians at UK latitudes: providing a choice. Nutrients, 10(4), 497.
Webb, A.R., Kazantzidis, A., Kift, R.C., Farrar, M.D., Wilkinson, J. & Rhodes, L.E. (2018b) Colour counts: sunlight and skin type as drivers of vitamin D deficiency at UK latitudes. Nutrients, 10(4), 457.
WHO/FAO (World Health Organization/Food and Agricultural Organization of the United Nations). (2006) Guidelines on food fortification with micronutrients. Available from: https://www.who.int/publications/i/item/9241594012 [Accessed 12 May 2022].