Food for thought - ILC metabolism in the context of helminth infections.
Journal
Mucosal immunology
ISSN: 1935-3456
Titre abrégé: Mucosal Immunol
Pays: United States
ID NLM: 101299742
Informations de publication
Date de publication:
06 2022
06 2022
Historique:
received:
23
05
2022
accepted:
09
08
2022
revised:
09
08
2022
pubmed:
1
9
2022
medline:
1
12
2022
entrez:
31
8
2022
Statut:
ppublish
Résumé
Helminths are multicellular ancient organisms residing as parasites at mucosal surfaces of their host. Through adaptation and co-evolution with their hosts, helminths have been able to develop tolerance mechanisms to limit inflammation and avoid expulsion. The study of helminth infections as an integral part of tissue immunology allowed us to understand fundamental aspects of mucosal and barrier immunology, which led to the discovery of a new group of tissue-resident immune cells, innate lymphoid cells (ILC), over a decade ago. Here, we review the intricate interplay between helminth infections and type 2 ILC (ILC2) biology, discuss the host metabolic adaptation to helminth infections and the metabolic pathways fueling ILC2 responses. We hypothesize that nutrient competition between host and helminths may have prevented chronic inflammation in the past and argue that a detailed understanding of the metabolic restraints imposed by helminth infections may offer new therapeutic avenues in the future.
Identifiants
pubmed: 36045216
doi: 10.1038/s41385-022-00559-y
pii: S1933-0219(22)01750-0
pmc: PMC9705246
doi:
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1234-1242Informations de copyright
© 2022. The Author(s).
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