Dach1 transcription factor regulates the expression of peripheral node addressin and lymphocyte trafficking in lymph nodes.
ECs, endothelial cells
Endothelial cell
HEV, High endothelial venules
ILNs, Inguinal lymph nodes
LNs, Lymph node
Lymph node
Lymphocyte
MAdCAM-1, mucosal addressin cell adhesion molecule-1
MLNs, Mesenteric lymph nodes
PNAd, peripheral node addressin
PPs, Peyer's patches
Trafficking
Transcription factor
mAb, monoclonal antibody
Journal
Current research in immunology
ISSN: 2590-2555
Titre abrégé: Curr Res Immunol
Pays: Netherlands
ID NLM: 101776898
Informations de publication
Date de publication:
2022
2022
Historique:
received:
07
02
2022
revised:
10
08
2022
accepted:
12
08
2022
entrez:
1
9
2022
pubmed:
2
9
2022
medline:
2
9
2022
Statut:
epublish
Résumé
Lymphocytes regulate the immune response by circulating between the vascular and lymphatic systems. High endothelial venules, HEVs, special blood vessels expressing selective adhesion molecules, such as PNAd and MAdCAM-1, mediate naïve lymphocyte migration from the vasculature into the lymph nodes and Peyer's patches. We have identified that DACH1 is abundantly expressed in developing HEV-type endothelial cells. DACH1 showed a restricted expression pattern in lymph node blood vessels during the late fetal and early neonatal periods, corresponding to HEV development. The proportion of MAdCAM-1
Identifiants
pubmed: 36045707
doi: 10.1016/j.crimmu.2022.08.008
pii: S2590-2555(22)00019-1
pmc: PMC9421177
doi:
Types de publication
Journal Article
Langues
eng
Pagination
175-185Informations de copyright
© 2022 The Authors.
Déclaration de conflit d'intérêts
The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
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