Oculocutaneous albinism and bleeding diathesis due to a novel deletion in the

Ashkenazi Jewish HPS-3 HPS3 Hermansky–Pudlak syndrome deletion oculocutaneous albinism

Journal

Frontiers in genetics
ISSN: 1664-8021
Titre abrégé: Front Genet
Pays: Switzerland
ID NLM: 101560621

Informations de publication

Date de publication:
2022
Historique:
received: 04 05 2022
accepted: 07 07 2022
entrez: 1 9 2022
pubmed: 2 9 2022
medline: 2 9 2022
Statut: epublish

Résumé

Hermansky-Pudlak syndrome (HPS) is a group of rare autosomal recessive disorders characterized by oculocutaneous albinism (OCA) and bleeding diathesis. To date, 11 HPS types have been reported (HPS-1 to HPS-11), each defined by disease-causing variants in specific genes. Variants in the

Identifiants

pubmed: 36046236
doi: 10.3389/fgene.2022.936064
pii: 936064
pmc: PMC9420964
doi:

Types de publication

Journal Article

Langues

eng

Pagination

936064

Informations de copyright

Copyright © 2022 Marek-Yagel, Abudi-Sinreich, Macarov, Veber, Shalva, Philosoph, Pode-Shakked, Malicdan and Anikster.

Déclaration de conflit d'intérêts

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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Auteurs

Dina Marek-Yagel (D)

Metabolic Disease Unit, Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Ramat Gan, Tel-Hahsomer, Israel.
Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel.

Shachar Abudi-Sinreich (S)

Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel.
Medical Genetics Branch, National Human Genome Research Institute, Bethesda, MD, United States.

Michal Macarov (M)

Department of Ophthalmology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.

Alvit Veber (A)

Metabolic Disease Unit, Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Ramat Gan, Tel-Hahsomer, Israel.

Nechama Shalva (N)

Metabolic Disease Unit, Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Ramat Gan, Tel-Hahsomer, Israel.

Amit Mary Philosoph (AM)

Metabolic Disease Unit, Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Ramat Gan, Tel-Hahsomer, Israel.

Ben Pode-Shakked (B)

Metabolic Disease Unit, Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Ramat Gan, Tel-Hahsomer, Israel.
Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel.
Talpiot Medical Leadership Program, Sheba Medical Center, Ramat Gan, Tel-Hahsomer, Israel.

May Christine V Malicdan (MCV)

Medical Genetics Branch, National Human Genome Research Institute, Bethesda, MD, United States.
NIH Undiagnosed Diseases Program, Common Fund, Office of the Director and National Human Genome Research Institute, Bethesda, MD, United States.

Yair Anikster (Y)

Metabolic Disease Unit, Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Ramat Gan, Tel-Hahsomer, Israel.
Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel.
The Wohl Institute for Translational Medicine, Sheba Medical Center, Ramat Gan, Tel-Hahsomer, Israel.

Classifications MeSH