Bcl-2-like protein-10 increases aggressive features of melanoma cells.

B-cell lymphoma-2 (Bcl-2)-like protein-10 (Bcl2L10) is the less studied member of Bcl-2 family proteins, with the controversial role in different cancer histotypes. Very recently, Bcl2L10 expression in melanoma tumor specimens and its role in melanoma response to therapy have been demonstrated. Here, the involvement of Bcl2L10 on the Endogenous Bcl2L10 protein expression was detected by western blotting analysis in a panel of patient-derived and commercially available human melanoma cells. Results demonstrated that Bcl2L10 acts as an inducer of Overall, data reported in this paper provide evidence supporting a positive role of Bcl2L10 in melanoma aggressive features.

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The authors declare that there are no conflicts of interest.