Electrochemical Detection of a Novel Pt(IV) Prodrug with the Metronidazole Axial Ligand in the Hypoxic Area.

Antineoplastic Agents / chemistry Carbon Cell Line, Tumor Cisplatin / chemistry Humans Hypoxia Ligands Metronidazole / pharmacology Platinum / chemistry Prodrugs / chemistry

Journal

Inorganic chemistry
ISSN: 1520-510X
Titre abrégé: Inorg Chem
Pays: United States
ID NLM: 0366543

Informations de publication

Date de publication:
19 Sep 2022
Historique:
pubmed: 2 9 2022
medline: 21 9 2022
entrez: 1 9 2022
Statut: ppublish

Résumé

We report herein a Pt(IV) prodrug with metronidazole in axial positions

Identifiants

DOI: 10.1021/acs.inorgchem.2c02062 PMID: 36047922
pubmed: 36047922
doi: 10.1021/acs.inorgchem.2c02062
doi:

Substances chimiques

Antineoplastic Agents 0
Ligands 0
Prodrugs 0
Metronidazole 140QMO216E
Platinum 49DFR088MY
Carbon 7440-44-0
Cisplatin Q20Q21Q62J

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

14705-14717

Auteurs

Daniil V Spector (DV)

Chemistry Department, Lomonosov Moscow State University, Leninskie gory 1,3, Moscow 119991, Russia.
National University of Science and Technology (MISIS), Leninskiy prospect 4, Moscow 119049, Russia.

Alexander S Erofeev (AS)

Chemistry Department, Lomonosov Moscow State University, Leninskie gory 1,3, Moscow 119991, Russia.
National University of Science and Technology (MISIS), Leninskiy prospect 4, Moscow 119049, Russia.

Petr V Gorelkin (PV)

National University of Science and Technology (MISIS), Leninskiy prospect 4, Moscow 119049, Russia.

Alexander N Vaneev (AN)

Chemistry Department, Lomonosov Moscow State University, Leninskie gory 1,3, Moscow 119991, Russia.
National University of Science and Technology (MISIS), Leninskiy prospect 4, Moscow 119049, Russia.
ORCID: 0000-0001-8201-8498

Roman A Akasov (RA)

I.M. Sechenov First Moscow State Medical University, Trubetskaya 8-2, Moscow 119991, Russia.
Federal Scientific Research Center "Crystallography and Photonics" Russian Academy of Sciences, Leninskiy Prospect 59, Moscow 119333, Russia.
ORCID: 0000-0001-6486-8114

Nikolay V Ul'yanovskiy (NV)

Core Facility Center "Arktika," Northern (Arctic) Federal University, Arkhangelsk 163002, Russia.

Vita N Nikitina (VN)

Chemistry Department, Lomonosov Moscow State University, Leninskie gory 1,3, Moscow 119991, Russia.

Alevtina S Semkina (AS)

Pirogov Russian National Research Medical University (RNRMU), Ostrovitianov 1, Moscow 117997, Russia.
Department of Basic and Applied Neurobiology, Serbsky National Medical Research Center for Psychiatry and Narcology, Kropotkinskiy 23, Moscow 119034, Russia.

Kseniya Yu Vlasova (KY)

Chemistry Department, Lomonosov Moscow State University, Leninskie gory 1,3, Moscow 119991, Russia.
Pirogov Russian National Research Medical University (RNRMU), Ostrovitianov 1, Moscow 117997, Russia.
ORCID: 0000-0003-3774-1323

Mikhail A Soldatov (MA)

The Smart Materials Research Institute Southern Federal University Sladkova, 178/24, Rostov-on-Don 344090, Russia.
ORCID: 0000-0003-1918-7875

Alexander L Trigub (AL)

National Research Center "Kurchatov Institute", Akademika Kurcha-tova pl.,1, Moscow 123182, Russia.

Dmitry A Skvortsov (DA)

Chemistry Department, Lomonosov Moscow State University, Leninskie gory 1,3, Moscow 119991, Russia.

Alexander V Finko (AV)

Chemistry Department, Lomonosov Moscow State University, Leninskie gory 1,3, Moscow 119991, Russia.

Nikolay V Zyk (NV)

Chemistry Department, Lomonosov Moscow State University, Leninskie gory 1,3, Moscow 119991, Russia.

Dmitry A Sakharov (DA)

Mendeleev University of Chemical Technology of Russia, Miusskaya sq. 9, Moscow 125047, Russia.

Alexander G Majouga (AG)

Chemistry Department, Lomonosov Moscow State University, Leninskie gory 1,3, Moscow 119991, Russia.
National University of Science and Technology (MISIS), Leninskiy prospect 4, Moscow 119049, Russia.
Mendeleev University of Chemical Technology of Russia, Miusskaya sq. 9, Moscow 125047, Russia.
ORCID: 0000-0002-5184-5551

Elena K Beloglazkina (EK)

Chemistry Department, Lomonosov Moscow State University, Leninskie gory 1,3, Moscow 119991, Russia.
ORCID: 0000-0001-6796-8241

Olga O Krasnovskaya (OO)

Chemistry Department, Lomonosov Moscow State University, Leninskie gory 1,3, Moscow 119991, Russia.
National University of Science and Technology (MISIS), Leninskiy prospect 4, Moscow 119049, Russia.
ORCID: 0000-0002-4948-2747

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Classifications MeSH

questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Antinéoplasiques › Electrochemical Detection of a Novel Pt(IV)...
questionsmedicales.fr › Produits chimiques inorganiques › Éléments › Carbone › Electrochemical Detection of a Novel Pt(IV)...
questionsmedicales.fr › Cellules › Cellules cultivées › Cellules cancéreuses en culture › Lignée cellulaire tumorale › Electrochemical Detection of a Novel Pt(IV)...
questionsmedicales.fr › Produits chimiques inorganiques › Composés du platine › Cisplatine › Electrochemical Detection of a Novel Pt(IV)...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Electrochemical Detection of a Novel Pt(IV)...
questionsmedicales.fr › États, signes et symptômes pathologiques › Signes et symptômes › Signes et symptômes respiratoires › Hypoxie › Electrochemical Detection of a Novel Pt(IV)...
questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Produits chimiques de laboratoire › Ligands › Electrochemical Detection of a Novel Pt(IV)...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Azoles › Imidazoles › Nitroimidazoles › Métronidazole › Electrochemical Detection of a Novel Pt(IV)...
questionsmedicales.fr › Produits chimiques inorganiques › Métaux › Métaux lourds › Platine › Electrochemical Detection of a Novel Pt(IV)...
questionsmedicales.fr › Préparations pharmaceutiques › Promédicaments › Electrochemical Detection of a Novel Pt(IV)...