Estimation of Ebola's spillover infection exposure in Sierra Leone based on sociodemographic and economic factors.
Journal
PloS one
ISSN: 1932-6203
Titre abrégé: PLoS One
Pays: United States
ID NLM: 101285081
Informations de publication
Date de publication:
2022
2022
Historique:
received:
22
10
2021
accepted:
06
07
2022
entrez:
1
9
2022
pubmed:
2
9
2022
medline:
9
9
2022
Statut:
epublish
Résumé
Zoonotic diseases spread through pathogens-infected animal carriers. In the case of Ebola Virus Disease (EVD), evidence supports that the main carriers are fruit bats and non-human primates. Further, EVD spread is a multi-factorial problem that depends on sociodemographic and economic (SDE) factors. Here we inquire into this phenomenon and aim at determining, quantitatively, the Ebola spillover infection exposure map and try to link it to SDE factors. To that end, we designed and conducted a survey in Sierra Leone and implement a pipeline to analyze data using regression and machine learning techniques. Our methodology is able (1) to identify the features that are best predictors of an individual's tendency to partake in behaviors that can expose them to Ebola infection, (2) to develop a predictive model about the spillover risk statistics that can be calibrated for different regions and future times, and (3) to compute a spillover exposure map for Sierra Leone. Our results and conclusions are relevant to identify the regions in Sierra Leone at risk of EVD spillover and, consequently, to design and implement policies for an effective deployment of resources (e.g., drug supplies) and other preventative measures (e.g., educational campaigns).
Identifiants
pubmed: 36048780
doi: 10.1371/journal.pone.0271886
pii: PONE-D-21-33881
pmc: PMC9436100
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0271886Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
Références
BMC Genomics. 2017 Aug 11;18(Suppl 5):566
pubmed: 28812539
Curr Top Microbiol Immunol. 2017;411:141-169
pubmed: 28653186
J Venom Anim Toxins Incl Trop Dis. 2014 Oct 03;20(1):44
pubmed: 25320574
Sex Transm Infect. 2002 Apr;78 Suppl 1:i97-105
pubmed: 12083453
Viruses. 2020 Nov 24;12(12):
pubmed: 33255243
Proc Natl Acad Sci U S A. 2016 Apr 19;113(16):4488-93
pubmed: 27035948
Phys Rev E Stat Nonlin Soft Matter Phys. 2012 Aug;86(2 Pt 1):021118
pubmed: 23005733
J Public Health Afr. 2016 Aug 17;7(1):534
pubmed: 28299152
PLoS Biol. 2021 Apr 20;19(4):e3001135
pubmed: 33878111
Geospat Health. 2016 May 31;11(2):428
pubmed: 27245803
Nat Commun. 2018 Oct 1;9(1):4013
pubmed: 30275474
Infect Dis Poverty. 2015 Oct 29;4:45
pubmed: 26510633
Biostatistics. 2000 Jun;1(2):123-40
pubmed: 12933515
Nat Hum Behav. 2018 Jan;2(1):4
pubmed: 30980046
PLoS Negl Trop Dis. 2015 Dec 31;9(12):e0004260
pubmed: 26720278
BMC Public Health. 2020 Oct 12;20(1):1539
pubmed: 33046052
Proc Natl Acad Sci U S A. 2016 Nov 29;113(48):13839-13844
pubmed: 27872284
SSM Popul Health. 2019 Nov 15;10:100472
pubmed: 31788533
Sci Rep. 2019 Mar 26;9(1):5151
pubmed: 30914669
Epidemics. 2018 Mar;22:50-55
pubmed: 28342787
Infect Dis Poverty. 2016 Jun 06;5(1):53
pubmed: 27264269
J Theor Biol. 2018 Apr 7;442:79-86
pubmed: 29330056
Milbank Q. 1993;71(2):279-322
pubmed: 8510603
Math Biosci Eng. 2018 Feb 1;15(1):21-56
pubmed: 29161826
PeerJ. 2017 Jul 7;5:e3544
pubmed: 28698825
Health Secur. 2019 Jul/Aug;17(4):268-275
pubmed: 31433279
Antiviral Res. 2016 Nov;135:62-73
pubmed: 27743917
MMWR Morb Mortal Wkly Rep. 2015 Oct 09;64(39):1108-11
pubmed: 26447483
Nat Rev Dis Primers. 2020 Feb 20;6(1):13
pubmed: 32080199
Public Health. 2017 Feb;143:60-70
pubmed: 28159028
Can J Exp Psychol. 2003 Sep;57(3):189-202
pubmed: 14596477
PLoS Negl Trop Dis. 2021 Aug 23;15(8):e0009683
pubmed: 34424896
J R Soc Interface. 2012 Dec 19;10(80):20120656
pubmed: 23256187
Trans R Soc Trop Med Hyg. 2015 Jun;109(6):366-78
pubmed: 25820266
BMC Med. 2015 Apr 23;13:96
pubmed: 25902936
mBio. 2015 Feb 19;6(2):e00137
pubmed: 25698835
Nat Rev Immunol. 2003 Aug;3(8):677-85
pubmed: 12974482
Sci Rep. 2018 May 22;8(1):7970
pubmed: 29789619
Nature. 2021 Sep;597(7877):539-543
pubmed: 34526718
PLoS One. 2015 Aug 28;10(8):e0135955
pubmed: 26317535
PLoS One. 2016 Oct 12;11(10):e0163544
pubmed: 27732614
Emerg Infect Dis. 2015 Aug;21(8):1447-50
pubmed: 26196358
Clin Infect Dis. 2016 Jan 1;62(1):125-6
pubmed: 26349549
N Engl J Med. 2014 Oct 16;371(16):1481-95
pubmed: 25244186
PLoS Biol. 2012;10(12):e1001456
pubmed: 23300379
J R Soc Interface. 2011 Dec 7;8(65):1796-803
pubmed: 21593026
Math Biosci Eng. 2019 Apr 11;16(4):3130-3143
pubmed: 31137254
Trop Med Int Health. 2006 Apr;11(4):490-503
pubmed: 16553932
J Chem Phys. 2020 Oct 21;153(15):155102
pubmed: 33092380