C5b-9 mediates ferroptosis of tubular epithelial cells in trichloroethylene-sensitization mice.

Animals Chelating Agents Complement Membrane Attack Complex / metabolism Epithelial Cells / metabolism Ferroptosis Mice Mice, Inbred BALB C Trichloroethylene / toxicity
C5b-9 Ca(2+) overload Ferroptosis OMDT Renal tubules

Journal

Ecotoxicology and environmental safety
ISSN: 1090-2414
Titre abrégé: Ecotoxicol Environ Saf
Pays: Netherlands
ID NLM: 7805381

Informations de publication

Date de publication:
01 Oct 2022
Historique:
received: 18 06 2022
revised: 14 08 2022
accepted: 23 08 2022
pubmed: 2 9 2022
medline: 28 9 2022
entrez: 1 9 2022
Statut: ppublish

Résumé

Occupational medicamentose-like dermatitis due to trichloroethylene (OMDT) is a key but unresolved question. OMDT patients often present multiple organ damage, including kidney damage. However, the underlying mechanism remains unknown. The purpose of our study was to explore the effect of tubule-specific C5b-9 deposition induced by TCE sensitization on renal tubular ferroptosis and its mechanism. By analyzing pathological changes of TCE-sensitization-mice kidney, we observed a significant renal tubular ferroptosis, which was alleviated by CD59, a C5b-9 inhibitory protein. Moreover, this phenomenon was also replicated in a C5b-9-attacked HK-2 cell model. Further experiments identified that C5b-9 induced cytosolic Ca

Identifiants

DOI: 10.1016/j.ecoenv.2022.114020 PMID: 36049330
pubmed: 36049330
pii: S0147-6513(22)00860-0
doi: 10.1016/j.ecoenv.2022.114020
pii:
doi:

Substances chimiques

Chelating Agents 0
Complement Membrane Attack Complex 0
Trichloroethylene 290YE8AR51

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

114020

Informations de copyright

Copyright © 2022 The Authors. Published by Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Auteurs

Zhibing Liu (Z)

Department of Dermatology, First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China; Key Laboratory of Dermatology (Anhui Medical University), Ministry of Education, Hefei, Anhui, China.

Jinru Ma (J)

Department of Occupational Health and Environmental Health, School of Public Health, Anhui Medical University, Hefei, Anhui, China.

Xulei Zuo (X)

Department of Occupational Health and Environmental Health, School of Public Health, Anhui Medical University, Hefei, Anhui, China.

Xuesong Zhang (X)

Department of Occupational Health and Environmental Health, School of Public Health, Anhui Medical University, Hefei, Anhui, China.

Yiting Hong (Y)

Department of Occupational Health and Environmental Health, School of Public Health, Anhui Medical University, Hefei, Anhui, China.

Shuyang Cai (S)

Department of Occupational Health and Environmental Health, School of Public Health, Anhui Medical University, Hefei, Anhui, China.

Hua Huang (H)

Department of Occupational Health and Environmental Health, School of Public Health, Anhui Medical University, Hefei, Anhui, China.

Feng Wang (F)

Department of Dermatology, Second Hospital of Anhui Medical University, Hefei, Anhui, China.

Changhao Wu (C)

School of Biosciences and Medicine, Faculty of Health and Medical Sciences, University of Surrey, Guildford, UK.

Jiaxiang Zhang (J)

Department of Occupational Health and Environmental Health, School of Public Health, Anhui Medical University, Hefei, Anhui, China. Electronic address: zhangjiaxiang@ahmu.edu.cn.

Qixing Zhu (Q)

Department of Dermatology, First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China; Key Laboratory of Dermatology (Anhui Medical University), Ministry of Education, Hefei, Anhui, China. Electronic address: zqxing@yeah.net.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › C5b-9 mediates ferroptosis of tubular...
questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Agents séquestrants › Chélateurs › C5b-9 mediates ferroptosis of tubular...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines du sang › Immunoprotéines › Protéines du système du complément › Complexe d'attaque membranaire du complément › C5b-9 mediates ferroptosis of tubular...
questionsmedicales.fr › Cellules › Cellules épithéliales › C5b-9 mediates ferroptosis of tubular...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Mort cellulaire › Mort cellulaire régulée › Ferroptose › C5b-9 mediates ferroptosis of tubular...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › C5b-9 mediates ferroptosis of tubular...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée BALB C › C5b-9 mediates ferroptosis of tubular...
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Hydrocarbures halogénés › Hydrocarbures chlorés › Trichloroéthylène › C5b-9 mediates ferroptosis of tubular...