The Long-Term Effectiveness and Safety of Cannabidiol-Enriched Oil in Children With Drug-Resistant Epilepsy.
Artisanal cannabis oil
Cannabidiol
Long-term follow-up
Refractory epilepsy
Seizures
Journal
Pediatric neurology
ISSN: 1873-5150
Titre abrégé: Pediatr Neurol
Pays: United States
ID NLM: 8508183
Informations de publication
Date de publication:
11 2022
11 2022
Historique:
received:
30
01
2022
revised:
15
05
2022
accepted:
17
06
2022
pubmed:
2
9
2022
medline:
19
10
2022
entrez:
1
9
2022
Statut:
ppublish
Résumé
Several retrospective studies on pediatric epilepsy reported positive effects of cannabidiol-enriched artisanal cannabis oil and pure cannabidiol oil on seizure reduction. This is a retrospective study of children and adolescents with refractory epilepsy caused by various etiologies who were treated with artisanal cannabis oil during January 2014 to June 2019, with at least one year follow-up. Of 114 patients, 84 (73.3%) reported some improvement in seizure frequency at some point during treatment. Fifty-one (59%) of the 86 patients who continued treatment for at least one year showed >50% improvement in seizure frequency. Seizure etiology, seizure type, and patients' age and sex were not found to be associated with the response to cannabidiol-enriched cannabis oil. Side effects were minor, and positive effects beyond seizure reduction were noted. Artisanal cannabidiol-enriched cannabis may be an effective and safe long-term treatment for refractory epilepsy.
Sections du résumé
BACKGROUND
Several retrospective studies on pediatric epilepsy reported positive effects of cannabidiol-enriched artisanal cannabis oil and pure cannabidiol oil on seizure reduction.
METHODS
This is a retrospective study of children and adolescents with refractory epilepsy caused by various etiologies who were treated with artisanal cannabis oil during January 2014 to June 2019, with at least one year follow-up.
RESULTS
Of 114 patients, 84 (73.3%) reported some improvement in seizure frequency at some point during treatment. Fifty-one (59%) of the 86 patients who continued treatment for at least one year showed >50% improvement in seizure frequency. Seizure etiology, seizure type, and patients' age and sex were not found to be associated with the response to cannabidiol-enriched cannabis oil. Side effects were minor, and positive effects beyond seizure reduction were noted.
CONCLUSIONS
Artisanal cannabidiol-enriched cannabis may be an effective and safe long-term treatment for refractory epilepsy.
Identifiants
pubmed: 36049378
pii: S0887-8994(22)00122-9
doi: 10.1016/j.pediatrneurol.2022.06.016
pii:
doi:
Substances chimiques
Anticonvulsants
0
Cannabidiol
19GBJ60SN5
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
15-19Informations de copyright
Copyright © 2022 Elsevier Inc. All rights reserved.