Curcumin-based-fluorescent probes targeting ALDH1A3 as a promising tool for glioblastoma precision surgery and early diagnosis.


Journal

Communications biology
ISSN: 2399-3642
Titre abrégé: Commun Biol
Pays: England
ID NLM: 101719179

Informations de publication

Date de publication:
01 09 2022
Historique:
received: 27 05 2021
accepted: 09 08 2022
entrez: 1 9 2022
pubmed: 2 9 2022
medline: 9 9 2022
Statut: epublish

Résumé

Glioblastoma (GBM) is the most aggressive primary brain tumour for which both effective treatments and efficient tools for an early-stage diagnosis are lacking. Herein, we present curcumin-based fluorescent probes that are able to bind to aldehyde dehydrogenase 1A3 (ALDH1A3), an enzyme overexpressed in glioma stem cells (GSCs) and associated with stemness and invasiveness of GBM. Two compounds are selective versus ALDH1A3, without showing any appreciable interaction with other ALDH1A isoenzymes. Indeed, their fluorescent signal is detectable only in our positive controls in vitro and absent in cells that lack ALDH1A3. Remarkably, in vivo, our Probe selectively accumulate in glioblastoma cells, allowing the identification of the growing tumour mass. The significant specificity of our compounds is the necessary premise for their further development into glioblastoma cells detecting probes to be possibly used during neurosurgical operations.

Identifiants

pubmed: 36050388
doi: 10.1038/s42003-022-03834-7
pii: 10.1038/s42003-022-03834-7
pmc: PMC9437101
doi:

Substances chimiques

Fluorescent Dyes 0
Aldehyde Oxidoreductases EC 1.2.-
Aldehyde Dehydrogenase EC 1.2.1.3
aldehyde dehydrogenase (NAD(P)+) EC 1.2.1.5
Curcumin IT942ZTH98

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

895

Informations de copyright

© 2022. The Author(s).

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Auteurs

Edoardo L M Gelardi (ELM)

Dipartimento di Scienze del Farmaco, University of Piemonte Orientale, Via Bovio, 6, 28100, Novara, Italy.

Diego Caprioglio (D)

Dipartimento di Scienze del Farmaco, University of Piemonte Orientale, Via Bovio, 6, 28100, Novara, Italy.

Giorgia Colombo (G)

Dipartimento di Scienze del Farmaco, University of Piemonte Orientale, Via Bovio, 6, 28100, Novara, Italy.

Erika Del Grosso (E)

Dipartimento di Scienze del Farmaco, University of Piemonte Orientale, Via Bovio, 6, 28100, Novara, Italy.

Daniele Mazzoletti (D)

Dipartimento di Scienze del Farmaco, University of Piemonte Orientale, Via Bovio, 6, 28100, Novara, Italy.

Daiana Mattoteia (D)

Dipartimento di Scienze del Farmaco, University of Piemonte Orientale, Via Bovio, 6, 28100, Novara, Italy.

Stefano Salamone (S)

Dipartimento di Scienze del Farmaco, University of Piemonte Orientale, Via Bovio, 6, 28100, Novara, Italy.

Davide M Ferraris (DM)

Dipartimento di Scienze del Farmaco, University of Piemonte Orientale, Via Bovio, 6, 28100, Novara, Italy.
IXTAL srl, Via Bovio 6, 28100, Novara, Italy.

Eleonora Aronica (E)

Department of (Neuro)Pathology, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
Stichting Epilepsie Instellingen Nederland (SEIN), Heemstede, The Netherlands.

Giulia Nato (G)

Department of Life Sciences and System Biology, University of Turin, Via Accademia Albertina 13, Turin, Italy.
Neuroscience Institute Cavalieri Ottolenghi (NICO), 10043, Orbassano, TO, Italy.

Annalisa Buffo (A)

Department of Life Sciences and System Biology, University of Turin, Via Accademia Albertina 13, Turin, Italy.
Department of Neuroscience Rita Levi Montalcini, University of Turin, Via Cherasco 15, Turin, Italy.

Menico Rizzi (M)

Dipartimento di Scienze del Farmaco, University of Piemonte Orientale, Via Bovio, 6, 28100, Novara, Italy.

Lorenzo Magrassi (L)

Neurosurgery, Department of Clinical, Surgical, Diagnostic and Pediatric Science, University of Pavia, Foundation IRCCS Policlinico San Matteo, 27100, Pavia, Italy.
Istituto Di Genetica Molecolare IGM-CNR, Via Abbiategrasso 207, 27100, Pavia, Italy.

Alberto Minassi (A)

Dipartimento di Scienze del Farmaco, University of Piemonte Orientale, Via Bovio, 6, 28100, Novara, Italy. alberto.minassi@uniupo.it.
PlantaChem srls, Via Canobio 4/6, 28100, Novara, Italy. alberto.minassi@uniupo.it.

Silvia Garavaglia (S)

Dipartimento di Scienze del Farmaco, University of Piemonte Orientale, Via Bovio, 6, 28100, Novara, Italy. silvia.garavaglia@uniupo.it.

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