Hematopoietic stem progenitor cells with malignancy-related gene mutations in patients with acquired aplastic anemia are characterized by the increased expression of CXCR4.
CXCR4
HLA class I allele‐lacking cell
acquire aplastic anemia
clonal hematopoiesis
hematopoietic stem progenitor cell (HSPC)
Journal
EJHaem
ISSN: 2688-6146
Titre abrégé: EJHaem
Pays: United States
ID NLM: 101761942
Informations de publication
Date de publication:
Aug 2022
Aug 2022
Historique:
received:
13
05
2022
revised:
06
06
2022
accepted:
08
06
2022
entrez:
2
9
2022
pubmed:
3
9
2022
medline:
3
9
2022
Statut:
epublish
Résumé
The phenotypic changes in hematopoietic stem progenitor cells (HSPCs) with somatic mutations of malignancy-related genes in patients with acquired aplastic anemia (AA) are poorly understood. As our initial study showed increased CXCR4 expression on HLA allele-lacking (HLA[-]) HSPCs that solely support hematopoiesis in comparison to redundant HLA(+) HSPCs in AA patients, we screened the HSPCs of patients with various types of bone marrow (BM) failure to investigate their CXCR4 expression. In comparison to healthy individuals (
Identifiants
pubmed: 36051022
doi: 10.1002/jha2.515
pii: JHA2515
pmc: PMC9422028
doi:
Types de publication
Journal Article
Langues
eng
Pagination
669-680Informations de copyright
© 2022 The Authors. eJHaem published by British Society for Haematology and John Wiley & Sons Ltd.
Déclaration de conflit d'intérêts
All authors declare no conflicts of interest in association with the present study.
Références
Blood. 2017 May 25;129(21):2908-2916
pubmed: 28232583
Blood Adv. 2018 Feb 27;2(4):390-400
pubmed: 29472446
Blood. 2017 Apr 27;129(17):2347-2358
pubmed: 28223278
Bone Marrow Transplant. 2013 Mar;48(3):452-8
pubmed: 23208313
Br J Haematol. 2000 Sep;110(3):563-72
pubmed: 10997965
Leukemia. 2004 May;18(5):1038-40
pubmed: 14762446
Exp Hematol. 2016 Oct;44(10):931-939.e3
pubmed: 27250585
J Cell Biochem. 2019 Jun;120(6):9724-9736
pubmed: 30582214
N Engl J Med. 2022 Jan 6;386(1):11-23
pubmed: 34986284
Blood. 2011 Dec 15;118(25):6601-9
pubmed: 21963603
J Cell Mol Med. 2015 Sep;19(9):2193-201
pubmed: 26033571
Br J Haematol. 2008 Jul;142(3):413-22
pubmed: 18544084
Blood. 2014 Oct 23;124(17):2698-704
pubmed: 25139356
Med Oncol. 2012 Jun;29(2):1202-8
pubmed: 21556934
Blood. 2011 Jun 23;117(25):6876-84
pubmed: 21527527
Leukemia. 2021 Nov;35(11):3257-3267
pubmed: 33824463
Haematologica. 2021 Jun 01;106(6):1581-1590
pubmed: 32439725
Leukemia. 2012 Jul;26(7):1722-5
pubmed: 22343521
Haematologica. 2019 Oct;104(10):e447-e450
pubmed: 30890597
Bioessays. 2010 Nov;32(11):1003-8
pubmed: 20803504
Leuk Res. 2012 Mar;36(3):281-6
pubmed: 21802140
Blood. 2002 Feb 15;99(4):1117-29
pubmed: 11830456
N Engl J Med. 2018 Oct 25;379(17):1643-1656
pubmed: 30354958
Blood. 2008 Jan 1;111(1):359-68
pubmed: 17898317
Blood. 2003 Aug 15;102(4):1211-6
pubmed: 12676778
Blood. 1999 Jul 1;94(1):62-73
pubmed: 10381499
Blood. 2017 Oct 26;130(17):1953-1957
pubmed: 28893734
J Clin Invest. 1985 Oct;76(4):1581-4
pubmed: 3863835
J Pathol. 2011 Jul;224(3):344-54
pubmed: 21618540
N Engl J Med. 2015 Jul 2;373(1):35-47
pubmed: 26132940