When Autoimmunity 'DRESSes up': A Case after Certolizumab Therapy.
Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS)
certolizumab
eosinophilia
lymphadenopathy
rheumatoid arthritis
Journal
European journal of case reports in internal medicine
ISSN: 2284-2594
Titre abrégé: Eur J Case Rep Intern Med
Pays: Italy
ID NLM: 101648453
Informations de publication
Date de publication:
2022
2022
Historique:
received:
15
06
2022
accepted:
27
06
2022
entrez:
2
9
2022
pubmed:
3
9
2022
medline:
3
9
2022
Statut:
epublish
Résumé
Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) is characterised by skin rash together with visceral organ involvement, lymphadenopathy, eosinophilia and atypical lymphocytosis. The syndrome is clinically heterogeneous, making diagnosis challenging. It has an annual incidence of 2 per 100,000 population and a mortality rate of 2-10%. We describe the first case of DRESS induced by certolizumab, a biologic disease-modifying antirheumatic drug (bioDMARD). Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) is an uncommon and under-reported syndrome.Its recognition is critical for treatment, especially in the emergency setting where most patients first present.In the case of unexplained fever, lymphadenopathy, cutaneous rash and characteristic laboratory findings (e.g., eosinophilia), after infectious causes have been ruled out, clinicians should always keep DRESS in mind and consider possible recent intake of a triggering drug.
Identifiants
pubmed: 36051169
doi: 10.12890/2022_003451
pii: 3451-1-29566-1-10-20220713
pmc: PMC9426962
doi:
Types de publication
Journal Article
Langues
eng
Pagination
003451Informations de copyright
© EFIM 2022.
Déclaration de conflit d'intérêts
Conflicts of Interests: The Authors declare that there are no competing interest
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