Genetically predicted telomere length and its relationship with neurodegenerative diseases and life expectancy.
AD, Alzheimer’s disease
ALS, Amyotrophic lateral sclerosis
Alzheimer’s disease
CI, Confidence Interval
FTD, Frontotemporal dementia
GWAS, Genome-wide association study
IV, Instrumental Variable
IVW, Inverse-Variance Weighted
LRRC34, Leucine Rich Repeat Containing 34
Life expectancy
MR, Mendelian Randomization
MR-PRESSO, MR-Pleiotropy RESidual Sum and Outlier
Mendelian randomization
Neurodegenerative diseases
OR, Odds ratio
PD, Parkinson’s disease
PSP, Progressive Supranuclear Palsy
SE, Standard Error
SNP, Single Nucleotide Polymorphism
TL, Telomere length
Telomere length
Journal
Computational and structural biotechnology journal
ISSN: 2001-0370
Titre abrégé: Comput Struct Biotechnol J
Pays: Netherlands
ID NLM: 101585369
Informations de publication
Date de publication:
2022
2022
Historique:
received:
08
03
2022
revised:
03
08
2022
accepted:
03
08
2022
entrez:
2
9
2022
pubmed:
3
9
2022
medline:
3
9
2022
Statut:
epublish
Résumé
Telomere length (TL) is a biomarker of biological aging. Shorter telomeres have been associated with mortality and increased rates of age-related diseases. However, observational studies are unable to conclude whether TL is causally associated with those outcomes. Mendelian randomization (MR) was developed for assessing causality using genetic variants in epidemiological research. The objective of this study was to test the potential causal role of TL in neurodegenerative disorders and life expectancy through MR analysis. Summary level data were extracted from the most recent genome-wide association studies for TL, Alzheimer's disease (AD), Parkinson's disease, Frontotemporal dementia, Amyotrophic Lateral Sclerosis, Progressive Supranuclear Palsy and life expectancy. MR estimates revealed that longer telomeres inferred a protective effect on risk of AD (OR = 0.964; adjusted p-value = 0.039). Moreover, longer telomeres were significantly associated with increased life expectancy (
Identifiants
pubmed: 36051868
doi: 10.1016/j.csbj.2022.08.006
pii: S2001-0370(22)00339-7
pmc: PMC9399257
doi:
Types de publication
Journal Article
Langues
eng
Pagination
4251-4256Informations de copyright
© 2022 The Author(s).
Déclaration de conflit d'intérêts
The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
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