Erythropoietin receptor regulates tumor mitochondrial biogenesis through iNOS and pAKT.
OXPHOS
VDAC1
erythropoietin receptor
mitochondrial biogenesis
nitric oxide (NO)
respirometry
tumor metabolism
Journal
Frontiers in oncology
ISSN: 2234-943X
Titre abrégé: Front Oncol
Pays: Switzerland
ID NLM: 101568867
Informations de publication
Date de publication:
2022
2022
Historique:
received:
23
06
2022
accepted:
18
07
2022
entrez:
2
9
2022
pubmed:
3
9
2022
medline:
3
9
2022
Statut:
epublish
Résumé
Erythropoietin receptor (EPOR) is widely expressed in healthy and malignant tissues. In certain malignancies, EPOR stimulates tumor growth. In healthy tissues, EPOR controls processes other than erythropoiesis, including mitochondrial metabolism. We hypothesized that EPOR also controls the mitochondrial metabolism in cancer cells. To test this hypothesis, we generated EPOR-knockdown cancer cells to grow tumor xenografts in mice and analyzed tumor cellular respiration
Identifiants
pubmed: 36052260
doi: 10.3389/fonc.2022.976961
pmc: PMC9425774
doi:
Types de publication
Journal Article
Langues
eng
Pagination
976961Informations de copyright
Copyright © 2022 Aboouf, Guscetti, von Büren, Armbruster, Ademi, Ruetten, Meléndez-Rodríguez, Rülicke, Seymer, Jacobs, Schneider Gasser, Aragones, Neumann, Gassmann and Thiersch.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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