PRC2 Loss and DNMT Inhibition Boost Viral Mimicry in Cancer.
Journal
Cancer discovery
ISSN: 2159-8290
Titre abrégé: Cancer Discov
Pays: United States
ID NLM: 101561693
Informations de publication
Date de publication:
02 09 2022
02 09 2022
Historique:
entrez:
2
9
2022
pubmed:
3
9
2022
medline:
9
9
2022
Statut:
ppublish
Résumé
In this issue of Cancer Discovery, Patel and colleagues explore the synergistic lethality of PRC2 inactivation and DNMT inhibition in malignant peripheral nerve sheath tumor cells. Reactivation of retrotransposons under this dual control suggests that the viral mimicry response contributes to enhanced cytotoxicity with potential clinical implications. See related article by Patel et al., p. 2120 (5).
Identifiants
pubmed: 36052503
pii: 708779
doi: 10.1158/2159-8290.CD-22-0733
doi:
Types de publication
Editorial
Comment
Langues
eng
Sous-ensembles de citation
IM
Pagination
2020-2022Commentaires et corrections
Type : CommentOn
Informations de copyright
©2022 American Association for Cancer Research.