Bone marrow-derived mesenchymal stem cells alleviate paclitaxel-induced mechanical allodynia in rats.
mechanical allodynia
mesenchymal stem cells
neuropathic pain
paclitaxel
rat
Journal
Journal of biochemical and molecular toxicology
ISSN: 1099-0461
Titre abrégé: J Biochem Mol Toxicol
Pays: United States
ID NLM: 9717231
Informations de publication
Date de publication:
Dec 2022
Dec 2022
Historique:
revised:
23
06
2022
received:
23
11
2021
accepted:
12
08
2022
pubmed:
3
9
2022
medline:
17
12
2022
entrez:
2
9
2022
Statut:
ppublish
Résumé
Anticancer drug paclitaxel (PTX) frequently causes painful peripheral neuropathy; however, no medication has been shown to be effective in the treatment of this debilitating side effect. We aimed to investigate the efficacy of two different doses of allogeneic bone marrow-derived mesenchymal stem cells (BM-MSCs) on PTX-induced mechanical allodynia and spinal cytokine levels and their localization to target tissues such as the spinal cord and sciatic nerve. After the development of mechanical allodynia with repeated PTX administration, two different doses of rat BM-MSCs, low or high (1 × 10
Substances chimiques
Paclitaxel
P88XT4IS4D
Tumor Necrosis Factor-alpha
0
Cytokines
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e23207Subventions
Organisme : Turkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK)
ID : 315S176
Informations de copyright
© 2022 Wiley Periodicals LLC.
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