Quality-of-life evaluations in children and adolescents with Ewing sarcoma treated with pencil-beam-scanning proton therapy.
Ewing sarcoma
children
proton therapy
proxy- and self-assessment
quality of life
teenagers
Journal
Pediatric blood & cancer
ISSN: 1545-5017
Titre abrégé: Pediatr Blood Cancer
Pays: United States
ID NLM: 101186624
Informations de publication
Date de publication:
12 2022
12 2022
Historique:
revised:
02
08
2022
received:
29
04
2022
accepted:
03
08
2022
pubmed:
3
9
2022
medline:
1
11
2022
entrez:
2
9
2022
Statut:
ppublish
Résumé
With improved survival rates for children with cancer, quality-of-life (QoL) issues have increasingly become the focus of attention. We report the QoL of children with Ewing sarcoma (EWS) treated with pencil-beam-scanning proton therapy (PT). A PEDQOL (QoL questionnaire for children 4-18 years) self/proxy questionnaire was used to prospectively assess the QoL of 23 children <18 years with EWS treated with PT. This questionnaire evaluates eight different domains. Children (self-rating) and parents (proxy-rating) filled out the questionnaire at the start of PT (E1), 2 months after treatment (E2), and thereafter once yearly (E≥3). Compared with healthy controls, parents rated the QoL of their children at E1 significantly worse in all but two (cognition and social functioning-family) domains. At E4, significant differences between the two groups only remained in three of eight domains. At E1, children self-rated their QoL significantly worse in the domain Physical functioning (p = .004) and significantly better in the domain Body image (p = .044) compared to healthy controls, whereas no significant differences were observed at E4. For the longitudinal comparison E1 versus E4, according to parents, Emotional functioning, Cognition and Social functioning-peers were slightly decreased 2 years after PT. The children rated Emotional functioning and Body image poorly 2 years after PT. Children with EWS usually recovered seemingly well to normal QoL levels 2 years after the end of PT. They tended to rate their QoL substantially higher than their parents. However, in the longitudinal analysis at 2 years, children rated their Emotional functioning and Body image scores poorly.
Sections du résumé
BACKGROUND
With improved survival rates for children with cancer, quality-of-life (QoL) issues have increasingly become the focus of attention. We report the QoL of children with Ewing sarcoma (EWS) treated with pencil-beam-scanning proton therapy (PT).
METHODS
A PEDQOL (QoL questionnaire for children 4-18 years) self/proxy questionnaire was used to prospectively assess the QoL of 23 children <18 years with EWS treated with PT. This questionnaire evaluates eight different domains. Children (self-rating) and parents (proxy-rating) filled out the questionnaire at the start of PT (E1), 2 months after treatment (E2), and thereafter once yearly (E≥3).
RESULTS
Compared with healthy controls, parents rated the QoL of their children at E1 significantly worse in all but two (cognition and social functioning-family) domains. At E4, significant differences between the two groups only remained in three of eight domains. At E1, children self-rated their QoL significantly worse in the domain Physical functioning (p = .004) and significantly better in the domain Body image (p = .044) compared to healthy controls, whereas no significant differences were observed at E4. For the longitudinal comparison E1 versus E4, according to parents, Emotional functioning, Cognition and Social functioning-peers were slightly decreased 2 years after PT. The children rated Emotional functioning and Body image poorly 2 years after PT.
CONCLUSIONS
Children with EWS usually recovered seemingly well to normal QoL levels 2 years after the end of PT. They tended to rate their QoL substantially higher than their parents. However, in the longitudinal analysis at 2 years, children rated their Emotional functioning and Body image scores poorly.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e29956Informations de copyright
© 2022 The Authors. Pediatric Blood & Cancer published by Wiley Periodicals LLC.
Références
Ward E, DeSantis C, Robbins A, et al. Childhood and adolescent cancer statistics, 2014. CA Cancer J Clin. 2014;64(2):83-103.
Esiashvili N, Goodman M, Marcus RB Jr. Changes in incidence and survival of Ewing sarcoma patients over the past 3 decades: Surveillance Epidemiology and End Results data. J Pediatr Hematol Oncol. 2008;30(6):425-430.
Gaspar N, Hawkins DS, Dirksen U, et al. Ewing sarcoma: current management and future approaches through collaboration. J Clin Oncol. 2015;33(27):3036-3046.
Ginsberg JP, Goodman P, Leisenring W, et al. Long-term survivors of childhood Ewing sarcoma: report from the childhood cancer survivor study. J Natl Cancer Inst. 2010;102(16):1272-1283.
Novakovic B, Fears TR, Horowitz ME, et al. Late effects of therapy in survivors of Ewing's sarcoma family tumors. J Pediatr Hematol Oncol. 1997;19(3):220-225.
Ranft A, Seidel C, Hoffmann C, et al. Quality of survivorship in a rare disease: clinicofunctional outcome and physical activity in an observational cohort study of 618 long-term survivors of Ewing sarcoma. J Clin Oncol. 2017;35(15):1704-1712.
Stish BJ, Ahmed SK, Rose PS, et al. Patient-reported functional and quality of life outcomes in a large cohort of long-term survivors of Ewing sarcoma. Pediatr Blood Cancer. 2015;62(12):2189-2196.
Stokke J, Sung L, Gupta A, et al. Systematic review and meta-analysis of objective and subjective quality of life among pediatric, adolescent, and young adult bone tumor survivors. Pediatr Blood Cancer. 2015;62(9):1616-1629.
Armstrong GT, Stovall M, Robison LL. Long-term effects of radiation exposure among adult survivors of childhood cancer: results from the childhood cancer survivor study. Radiat Res. 2010;174(6):840-850.
Frisch S, Timmermann B. The evolving role of proton beam therapy for sarcomas. Clin Oncol (R Coll Radiol). 2017;29(8):500-506.
Weber DC, Murray FR, Correia D, et al. Pencil beam scanned protons for the treatment of patients with Ewing sarcoma. Pediatr Blood Cancer. 2017;64(12):e26688.
Calaminus G, Weinspach S, Teske C, et al. Quality of survival in children and adolescents after treatment for childhood cancer: the influence of reported late effects on health related quality of life. Klin Padiatr. 2007;219(3):152-157.
Rodrigues KE, Machado ST, Ferreira MA, et al. Health-related quality of life among teenagers during cancer treatment in a developing country: patients' and proxies' reports. Pediatr Hematol Oncol. 2013;30(4):307-316.
Fu L, Talsma D, Beaz F. Health status and health-related quality of life on survivors of cancer in childhood in Central America. Pediatr Blood Cancer. 2005;45:585-586.
Horsman J, Fluchel M, Furlong W, et al. Agreement of the Health Utilities Index scores among survivors of cancer in childhood: their parents and their doctors in Urugay [ISTAHC Conference June 22-25]. Value Health. 2003;6(3):233.
Glaser AW, Furlong W, Walker DA, et al. Applicability of the Health Utilities Index to a population of childhood survivors of central nervous system tumours in the U.K. Eur J Cancer. 1999;35(2):256-261.
Jones JM, McPherson CJ, Zimmermann C, et al. Assessing agreement between terminally ill cancer patients' reports of their quality of life and family caregiver and palliative care physician proxy ratings. J Pain Symptom Manage. 2011;42(3):354-365.
Rensen N, Steur LMH, Schepers SA, et al. Determinants of health-related quality of life proxy rating disagreement between caregivers of children with cancer. Qual Life Res. 2020;29(4):901-912.
Pan R, Egberts MR, Nascimento LC, et al. Health-related quality of life in adolescent survivors of burns: agreement on self-reported and mothers' and fathers' perspectives. Burns. 2015;41(5):1107-1113.
Weitkamp K, Daniels JK, Rosenthal S, et al. Health-related quality of life: cross-informant agreement of father, mother, and self-report for children and adolescents in outpatient psychotherapy treatment. Child Adolesc Ment Health. 2013;18(2):88-94.
Klassen AF, Strohm SJ, Maurice-Stam H, et al. Quality of life questionnaires for children with cancer and childhood cancer survivors: a review of the development of available measures. Support Care Cancer. 2010;18(9):1207-1217.