Keratinocyte PIEZO1 modulates cutaneous mechanosensation.
Piezo1
cell biology
keratinocyte
mechanotransduction
mouse
neuroscience
pain
touch sensation
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
02 09 2022
02 09 2022
Historique:
received:
22
12
2020
accepted:
01
09
2022
pubmed:
3
9
2022
medline:
28
9
2022
entrez:
2
9
2022
Statut:
epublish
Résumé
Epidermal keratinocytes mediate touch sensation by detecting and encoding tactile information to sensory neurons. However, the specific mechanotransducers that enable keratinocytes to respond to mechanical stimulation are unknown. Here, we found that the mechanically-gated ion channel PIEZO1 is a key keratinocyte mechanotransducer. Keratinocyte expression of PIEZO1 is critical for normal sensory afferent firing and behavioral responses to mechanical stimuli in mice.
Identifiants
pubmed: 36053009
doi: 10.7554/eLife.65987
pii: 65987
pmc: PMC9512397
doi:
pii:
Substances chimiques
Ion Channels
0
Piezo1 protein, mouse
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NINDS NIH HHS
ID : F31 NS125941
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS040538
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS070711
Pays : United States
Organisme : NINDS NIH HHS
ID : R37 NS108278
Pays : United States
Informations de copyright
© 2022, Mikesell et al.
Déclaration de conflit d'intérêts
AM, OI, FM, KS, AM, CS No competing interests declared
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