Cisplatin-Loaded Tobacco Mosaic Virus for Ovarian Cancer Treatment.
Journal
Biomacromolecules
ISSN: 1526-4602
Titre abrégé: Biomacromolecules
Pays: United States
ID NLM: 100892849
Informations de publication
Date de publication:
10 Oct 2022
10 Oct 2022
Historique:
pubmed:
3
9
2022
medline:
12
10
2022
entrez:
2
9
2022
Statut:
ppublish
Résumé
Ovarian cancer is the foremost cause of gynecological cancer and a major cause of cancer death in women. Treatment for advanced stage is surgical debulking followed by chemotherapy; however, most patients relapse with more aggressive and therapy-resistant tumors. There is a need to develop drug delivery approaches to deliver platinum therapies to tumors to increase efficacy while maintaining safety. Toward this goal, we utilized the protein nanotubes from the plant virus, tobacco mosaic virus (TMV), as a drug carrier. Specifically, the nanochannel of TMV was loaded with the active dication form of cisplatin (cisPt
Identifiants
pubmed: 36053908
doi: 10.1021/acs.biomac.2c00831
pmc: PMC9831511
mid: NIHMS1860385
doi:
Substances chimiques
Drug Carriers
0
Vascular Endothelial Growth Factor A
0
Platinum
49DFR088MY
Cisplatin
Q20Q21Q62J
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
4379-4387Subventions
Organisme : NCI NIH HHS
ID : R01 CA224605
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA253615
Pays : United States
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