[Castleman-like presentation of systemic lupus: About a case report].
Présentation « Castleman-like » de lupus systémique : à propos d’un cas.
Castleman disease
Lupus systémique
Maladie de Castleman
Systemic lupus
Journal
La Revue de medecine interne
ISSN: 1768-3122
Titre abrégé: Rev Med Interne
Pays: France
ID NLM: 8101383
Informations de publication
Date de publication:
Feb 2023
Feb 2023
Historique:
received:
03
06
2022
revised:
29
07
2022
accepted:
21
08
2022
pubmed:
3
9
2022
medline:
14
2
2023
entrez:
2
9
2022
Statut:
ppublish
Résumé
Castleman disease is a rare lymphoproliferation, which may mimic systemic lupus. Conversely, systemic lupus sometimes presents like an hematological malignancy. In these cases, a "Castleman-like" histology has been exceptionally described. A 55-year-old female treated by methotrexate for systemic lupus with skin and joint involvement presented weight loss, polyadenopathy and clinical signs of lupus flare. Biology showed pancytopenia, complement activation, and positive anti-DNA antibodies. PET/CT showed hypermetabolic polyadenopathy. The lymph node biopsy showed "Castleman-like" features. Treatment with corticosteroids and azathioprine resulted in complete remission. Systemic lupus and Castleman disease may share common clinical, biological, and histological features. The presence of specific elements of systemic lupus flare and the remission obtained by low-dose corticosteroids results in considering the diagnosis of Castleman-like systemic lupus and avoiding treatment intensification.
Identifiants
pubmed: 36055947
pii: S0248-8663(22)00610-5
doi: 10.1016/j.revmed.2022.08.006
pii:
doi:
Substances chimiques
Adrenal Cortex Hormones
0
Types de publication
Case Reports
English Abstract
Journal Article
Langues
fre
Sous-ensembles de citation
IM
Pagination
85-88Informations de copyright
Copyright © 2022 Société Nationale Française de Médecine Interne (SNFMI). Published by Elsevier Masson SAS. All rights reserved.