IRES-mediated Wnt2 translation in apoptotic neurons triggers astrocyte dedifferentiation.
Journal
NPJ Regenerative medicine
ISSN: 2057-3995
Titre abrégé: NPJ Regen Med
Pays: United States
ID NLM: 101699846
Informations de publication
Date de publication:
02 Sep 2022
02 Sep 2022
Historique:
received:
29
08
2021
accepted:
08
08
2022
entrez:
2
9
2022
pubmed:
3
9
2022
medline:
3
9
2022
Statut:
epublish
Résumé
Reactive astrogliosis usually bears some properties of neural progenitors. How injury triggers astrocyte dedifferentiation remains largely unclear. Here, we report that ischemia induces rapid up-regulation of Wnt2 protein in apoptotic neurons and activation of canonical Wnt signaling in reactive astrocytes in mice, primates and human. Local delivery of Wnt2 shRNA abolished the dedifferentiation of astrocytes while over-expressing Wnt2 promoted progenitor marker expression and neurogenesis. Both the activation of Wnt signaling and dedifferentiation of astrocytes was compromised in ischemic caspase-3
Identifiants
pubmed: 36056026
doi: 10.1038/s41536-022-00248-1
pii: 10.1038/s41536-022-00248-1
pmc: PMC9440034
doi:
Types de publication
Journal Article
Langues
eng
Pagination
42Subventions
Organisme : National Natural Science Foundation of China (National Science Foundation of China)
ID : 82171346,31970907
Informations de copyright
© 2022. The Author(s).
Références
J Biol Chem. 2001 Feb 23;276(8):5668-75
pubmed: 11063741
J Neurosci. 2012 Apr 11;32(15):5132-43
pubmed: 22496559
Cell Death Differ. 2005 Jun;12(6):554-62
pubmed: 15818401
Nature. 2000 Jun 22;405(6789):951-5
pubmed: 10879536
Nat Rev Neurosci. 2011 Feb;12(2):88-104
pubmed: 21248788
Science. 2014 Oct 10;346(6206):237-41
pubmed: 25301628
Neurobiol Dis. 2010 Feb;37(2):267-74
pubmed: 19909815
Nature. 2020 Jun;582(7813):550-556
pubmed: 32581380
Nat Cell Biol. 2013 Oct;15(10):1164-75
pubmed: 24056302
J Neurosci. 2012 Jun 6;32(23):7926-40
pubmed: 22674268
Nucleic Acids Res. 2015 Apr 20;43(7):3764-75
pubmed: 25779044
J Neurosci. 2017 Mar 22;37(12):3331-3341
pubmed: 28258169
Curr Drug Targets. 2008 Jul;9(7):558-64
pubmed: 18673241
Nat Med. 2011 Jul 03;17(7):860-6
pubmed: 21725296
Development. 1999 Oct;126(20):4557-68
pubmed: 10498690
J Neurosci Methods. 2003 Oct 15;129(1):87-93
pubmed: 12951236
Mol Ther. 2020 Jan 8;28(1):217-234
pubmed: 31551137
Cell Stem Cell. 2015 Nov 5;17(5):624-34
pubmed: 26456685
Sci Signal. 2010 Feb 23;3(110):ra13
pubmed: 20179271
Cell. 2009 Mar 20;136(6):1136-47
pubmed: 19303855
EMBO J. 2015 Nov 12;34(22):2804-19
pubmed: 26438726
Nat Neurosci. 2008 Nov;11(11):1247-51
pubmed: 18956012
Nat Neurosci. 2014 Jun;17(6):801-3
pubmed: 24747576
Prog Brain Res. 2017;230:69-97
pubmed: 28552236
J Neurosci. 2013 Apr 10;33(15):6278-84
pubmed: 23575827
Cell Rep. 2017 Jan 10;18(2):391-405
pubmed: 28076784
Cell. 2021 Oct 14;184(21):5465-5481.e16
pubmed: 34582787
Cell Stem Cell. 2014 Feb 6;14(2):188-202
pubmed: 24360883
FASEB J. 2016 Oct;30(10):3271-3284
pubmed: 27335371
Glia. 2015 Aug;63(8):1452-68
pubmed: 25965557
Nat Neurosci. 2018 Jan;21(1):9-15
pubmed: 29269757
Cell. 2019 Mar 7;176(6):1407-1419.e14
pubmed: 30827680
Proc Natl Acad Sci U S A. 2002 Apr 16;99(8):5400-5
pubmed: 11943866
Neurosci Bull. 2021 Nov;37(11):1625-1636
pubmed: 34283396
Dev Cell. 2009 Aug;17(2):279-89
pubmed: 19686688
PLoS One. 2010 Feb 23;5(2):e9370
pubmed: 20186325
Stem Cells. 2011 Jun;29(6):907-12
pubmed: 21557389
Neuron. 2019 Sep 25;103(6):1086-1095.e5
pubmed: 31488328
Cell Rep. 2021 Aug 10;36(6):109508
pubmed: 34380036
Proc Natl Acad Sci U S A. 2019 Jul 2;116(27):13621-13630
pubmed: 31196958
Cell Death Differ. 2005 Jun;12(6):585-91
pubmed: 15900315
J Neurosci. 2008 Aug 13;28(33):8376-82
pubmed: 18701700
Nucleic Acids Res. 2010 Aug;38(14):4665-74
pubmed: 20385593
Nature. 2016 Apr 14;532(7598):195-200
pubmed: 27027288
Neurosci Bull. 2021 Apr;37(4):440-460
pubmed: 33606177
Nature. 2013 May 16;497(7449):369-73
pubmed: 23615612
Glia. 2019 Dec;67(12):2221-2247
pubmed: 31429127
Nat Rev Mol Cell Biol. 2005 Apr;6(4):318-27
pubmed: 15803138
Science. 2003 Dec 12;302(5652):1984-8
pubmed: 14671310
Nature. 2012 Jan 25;481(7382):457-62
pubmed: 22281595
Cell Stem Cell. 2013 Apr 4;12(4):426-39
pubmed: 23561443
Nature. 2018 Sep;561(7723):396-400
pubmed: 30158698