Relative ellipsoid zone reflectivity and its association with disease severity in age-related macular degeneration: a MACUSTAR study report.

Cross-Sectional Studies Disease Progression Humans Macular Degeneration / complications Reproducibility of Results Retinal Drusen Severity of Illness Index Tomography, Optical Coherence

Journal

Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288

Informations de publication

Date de publication:
02 Sep 2022
Historique:
received: 10 05 2022
accepted: 22 08 2022
entrez: 2 9 2022
pubmed: 3 9 2022
medline: 9 9 2022
Statut: epublish

Résumé

Quantification of the relative ellipsoid zone reflectivity (rEZR) might be a structural surrogate parameter for an early disease progression in the context of age-related macular degeneration (AMD). Within the European multicenter, cross-sectional MACUSTAR study, we have devised an automatic approach to determine the mean rEZR [arbitrary units, AU] at two independent visits in SD-OCT volume scans in study participants. Linear mixed-effects models were applied to analyze the association of AMD stage and AMD associated high-risk features including presence of pigmentary abnormalities, reticular pseudodrusen (RPD), volume of the retinal-pigment-epithelial-drusenoid-complex (RPEDC) with the rEZR. Intra-class correlation coefficients (ICC) were determined for rEZR reliability analysis. Within the overall study cohort (301 participants), we could observe decreased rEZR values (coefficient estimate ± standard error) of - 8.05 ± 2.44 AU (p = 0.0011) in the intermediate and of - 22.35 ± 3.28 AU (p < 0.0001) in the late AMD group. RPD presence was significantly associated with the rEZR in iAMD eyes (- 6.49 ± 3.14 AU; p = 0.0403), while there was a good ICC of 0.846 (95% confidence interval: 0.809; 0.876) in the overall study cohort. This study showed an association of rEZR with increasing disease severity and the presence of iAMD high-risk features. Further studies are necessary to evaluate the rEZR's value as a novel biomarker for AMD and disease progression.

Identifiants

DOI: 10.1038/s41598-022-18875-5 PMID: 36056113 PMC: PMC9440143
pubmed: 36056113
doi: 10.1038/s41598-022-18875-5
pii: 10.1038/s41598-022-18875-5
pmc: PMC9440143
doi:

Types de publication

Journal Article Multicenter Study Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

14933

Investigateurs

H Agostini (H)
L Altay (L)
R Atia (R)
F Bandello (F)
P G Basile (PG)
C Behning (C)
M Belmouhand (M)
M Berger (M)
A Binns (A)
C J F Boon (CJF)
M Böttger (M)
C Bouchet (C)
J E Brazier (JE)
T Butt (T)
C Carapezzi (C)
J Carlton (J)
A Carneiro (A)
A Charil (A)
R Coimbra (R)
M Cozzi (M)
D P Crabb (DP)
J Cunha-Vaz (J)
C Dahlke (C)
L de Sisternes (L)
H Dunbar (H)
R P Finger (RP)
E Fletcher (E)
H Floyd (H)
C Francisco (C)
M Gutfleisch (M)
R Hogg (R)
F G Holz (FG)
C B Hoyng (CB)
A Kilani (A)
J Krätzschmar (J)
L Kühlewein (L)
M Larsen (M)
S Leal (S)
Y T E Lechanteur (YTE)
U F O Luhmann (UFO)
A Lüning (A)
I Marques (I)
C Martinho (C)
G Montesano (G)
Z Mulyukov (Z)
M Paques (M)
B Parodi (B)
M Parravano (M)
S Penas (S)
T Peters (T)
T Peto (T)
M Pfau (M)
S Poor (S)
S Priglinger (S)
D Rowen (D)
G S Rubin (GS)
J Sahel (J)
C Sánchez (C)
O Sander (O)
M Saßmannshausen (M)
M Schmid (M)
S Schmitz-Valckenberg (S)
H Schrinner-Fenske (H)
J Siedlecki (J)
R Silva (R)
A Skelly (A)
E Souied (E)
G Staurenghi (G)
L Stöhr (L)
D J Taylor (DJ)
J H Terheyden (JH)
S Thiele (S)
A Tufail (A)
M Varano (M)
L Vieweg (L)
L Wintergerst (L)
A Wolf (A)
N Zakaria (N)

Informations de copyright

© 2022. The Author(s).

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Auteurs

Marlene Saßmannshausen (M)

Department of Ophthalmology, University of Bonn, Venusberg-Campus 1, 53127, Bonn, Germany.
GRADE Reading Center, University of Bonn, Bonn, Germany.

Charlotte Behning (C)

Institute for Medical Biometry, Informatics and Epidemiology, University of Bonn, Bonn, Germany.

Ben Isselmann (B)

Department of Ophthalmology, University of Bonn, Venusberg-Campus 1, 53127, Bonn, Germany.

Matthias Schmid (M)

Institute for Medical Biometry, Informatics and Epidemiology, University of Bonn, Bonn, Germany.

Robert P Finger (RP)

Department of Ophthalmology, University of Bonn, Venusberg-Campus 1, 53127, Bonn, Germany.

Frank G Holz (FG)

Department of Ophthalmology, University of Bonn, Venusberg-Campus 1, 53127, Bonn, Germany.
GRADE Reading Center, University of Bonn, Bonn, Germany.

Steffen Schmitz-Valckenberg (S)

Department of Ophthalmology, University of Bonn, Venusberg-Campus 1, 53127, Bonn, Germany.
GRADE Reading Center, University of Bonn, Bonn, Germany.
John A. Moran Eye Center, Department of Ophthalmology and Visual Sciences, University of Utah, Salt Lake City, UT, USA.

Maximilian Pfau (M)

Department of Ophthalmology, University of Bonn, Venusberg-Campus 1, 53127, Bonn, Germany.
GRADE Reading Center, University of Bonn, Bonn, Germany.
Ophthalmic Genetics and Visual Function Branch, National Eye Institute, Bethesda, MD, USA.

Sarah Thiele (S)

Department of Ophthalmology, University of Bonn, Venusberg-Campus 1, 53127, Bonn, Germany. sarah.thiele@ukbonn.de.
GRADE Reading Center, University of Bonn, Bonn, Germany. sarah.thiele@ukbonn.de.

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questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études transversales › Relative ellipsoid zone reflectivity and its...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Caractéristiques de la maladie › Évolution de la maladie › Relative ellipsoid zone reflectivity and its...
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questionsmedicales.fr › Maladies de l'oeil › Rétinopathies › Dégénérescence de la rétine › Dégénérescence maculaire › Relative ellipsoid zone reflectivity and its...
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questionsmedicales.fr › Maladies de l'oeil › Rétinopathies › Dégénérescence de la rétine › Druses de la rétine › Relative ellipsoid zone reflectivity and its...
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