COVID-19 immunopathology: From acute diseases to chronic sequelae.
SARS coronavirus
immnopathology
immune responses
respiratory tract
Journal
Journal of medical virology
ISSN: 1096-9071
Titre abrégé: J Med Virol
Pays: United States
ID NLM: 7705876
Informations de publication
Date de publication:
01 2023
01 2023
Historique:
revised:
27
08
2022
received:
09
07
2022
accepted:
29
08
2022
pubmed:
4
9
2022
medline:
11
1
2023
entrez:
3
9
2022
Statut:
ppublish
Résumé
The clinical manifestation of coronavirus disease 2019 (COVID-19) mainly targets the lung as a primary affected organ, which is also a critical site of immune cell activation by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However, recent reports also suggest the involvement of extrapulmonary tissues in COVID-19 pathology. The interplay of both innate and adaptive immune responses is key to COVID-19 management. As a result, a robust innate immune response provides the first line of defense, concomitantly, adaptive immunity neutralizes the infection and builds memory for long-term protection. However, dysregulated immunity, both innate and adaptive, can skew towards immunopathology both in acute and chronic cases. Here we have summarized some of the recent findings that provide critical insight into the immunopathology caused by SARS-CoV-2, in acute and post-acute cases. Finally, we further discuss some of the immunomodulatory drugs in preclinical and clinical trials for dampening the immunopathology caused by COVID-19.
Identifiants
pubmed: 36056655
doi: 10.1002/jmv.28122
pmc: PMC9537925
mid: NIHMS1834587
doi:
Types de publication
Journal Article
Review
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
e28122Subventions
Organisme : NIA NIH HHS
ID : R01 AG069264
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI147394
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI112844
Pays : United States
Organisme : NIH HHS
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI154598
Pays : United States
Informations de copyright
© 2022 The Authors. Journal of Medical Virology published by Wiley Periodicals LLC.
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