Synthesis and physical and biological properties of 1,3-diaza-2-oxophenoxazine-conjugated oligonucleotides.

Animals DNA Deoxyribonucleotides Guanine Mice Oligonucleotides / pharmacology Oligonucleotides, Antisense / genetics Oxazines Pharmaceutical Preparations RNA, Long Noncoding
Artificial nucleic acid G-clamp Nucleic acid-based therapy Oligonucleotide delivery Phenoxazine base

Journal

Bioorganic & medicinal chemistry
ISSN: 1464-3391
Titre abrégé: Bioorg Med Chem
Pays: England
ID NLM: 9413298

Informations de publication

Date de publication:
15 10 2022
Historique:
received: 08 07 2022
revised: 18 08 2022
accepted: 19 08 2022
pubmed: 4 9 2022
medline: 24 9 2022
entrez: 3 9 2022
Statut: ppublish

Résumé

The artificial nucleobase 1,3-diaza-2-oxophenoxazine (tC

Identifiants

DOI: 10.1016/j.bmc.2022.116972 PMID: 36057217
pubmed: 36057217
pii: S0968-0896(22)00365-0
doi: 10.1016/j.bmc.2022.116972
pii:
doi:

Substances chimiques

1,3-diaza-2-oxophenoxazine 0
Deoxyribonucleotides 0
Oligonucleotides 0
Oligonucleotides, Antisense 0
Oxazines 0
Pharmaceutical Preparations 0
RNA, Long Noncoding 0
Guanine 5Z93L87A1R
DNA 9007-49-2

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

116972

Informations de copyright

Copyright © 2022 Elsevier Ltd. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Auteurs

Ryohei Yamaji (R)

Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan.

Osamu Nakagawa (O)

Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan.

Yuki Kishimoto (Y)

Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan.

Akane Fujii (A)

Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan.

Tomoki Matsumura (T)

Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan.

Taisuke Nakayama (T)

National Institutes of Biomedical Innovation, Health and Nutrition (NIBIOHN), 7-6-8 Saito-Asagi, Ibaraki, Osaka 567-0085, Japan.

Haruhiko Kamada (H)

National Institutes of Biomedical Innovation, Health and Nutrition (NIBIOHN), 7-6-8 Saito-Asagi, Ibaraki, Osaka 567-0085, Japan.

Takashi Osawa (T)

Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan.

Takao Yamaguchi (T)

Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan.

Satoshi Obika (S)

Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan; Institute for Open and Transdisciplinary Research Initiatives (OTRI), Osaka University, 1-1 Yamadaoka, Suita, Osaka 565-0871, Japan; National Institutes of Biomedical Innovation, Health and Nutrition (NIBIOHN), 7-6-8 Saito-Asagi, Ibaraki, Osaka 567-0085, Japan. Electronic address: obika@phs.osaka-u.ac.jp.

Articles similaires

Evaluating the efficacy of telesurgery with dual console SSI Mantra Surgical Robotic System: experiment on animal model and clinical trials.

Sudhir Prem Srivastava, Vishwajyoti Pascual Srivastava, Avinesh Singh et al.
1.00
Robotic Surgical Procedures Animals Humans Telemedicine Models, Animal

Odour generalisation and detection dog training.

Lyn Caldicott, Thomas W Pike, Helen E Zulch et al.
1.00
Animals Odorants Dogs Generalization, Psychological Smell

Impact of supply chain disruptions and drug shortages on drug utilization: A scoping review protocol.

Araniy Santhireswaran, Martin Ho, Kaitlin Fuller et al.
1.00
Humans Pharmaceutical Preparations Drug Utilization Prescription Drugs

FBXO22 inhibits colitis and colorectal carcinogenesis by regulating the degradation of the S2448-phosphorylated form of mTOR.

Minle Li, Xuan Chen, Pengfei Qu et al.
1.00
Animals TOR Serine-Threonine Kinases Colorectal Neoplasms Colitis Mice

Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Synthesis and physical and biological...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ADN › Synthesis and physical and biological...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Nucléotides › Désoxyribonucléotides › Synthesis and physical and biological...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Purines › Purinones › Hypoxanthines › Guanine › Synthesis and physical and biological...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Synthesis and physical and biological...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Nucléotides › Polynucléotides › Oligonucléotides › Synthesis and physical and biological...
questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Produits chimiques de laboratoire › Sondes moléculaires › Sondes d'acide nucléique › Éléments antisens (génétique) › Oligonucléotides antisens › Synthesis and physical and biological...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Oxazines › Synthesis and physical and biological...
questionsmedicales.fr › Préparations pharmaceutiques › Synthesis and physical and biological...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ARN › ARN non traduit › ARN long non codant › Synthesis and physical and biological...