The tumour immune microenvironment and microbiome of pancreatic intraductal papillary mucinous neoplasms.

Humans Adenocarcinoma, Mucinous Carcinoma, Pancreatic Ductal / pathology Pancreatic Neoplasms / pathology Pancreatic Ducts Microbiota Tumor Microenvironment

Journal

The lancet. Gastroenterology & hepatology
ISSN: 2468-1253
Titre abrégé: Lancet Gastroenterol Hepatol
Pays: Netherlands
ID NLM: 101690683

Informations de publication

Date de publication:
12 2022
Historique:
received: 05 05 2022
revised: 05 07 2022
accepted: 06 07 2022
pubmed: 4 9 2022
medline: 16 11 2022
entrez: 3 9 2022
Statut: ppublish

Résumé

Pancreatic intraductal papillary mucinous neoplasms (IPMNs) have gained substantial attention because they represent one of the only radiographically identifiable precursors of invasive pancreatic ductal adenocarcinoma. Although most of these neoplasms have low-grade dysplasia and will remain indolent, a subset of IPMNs will progress to invasive cancer. The role of the immune system in the progression of IPMNs is unclear, but understanding its role could reveal the mechanism of neoplastic progression and targets for immunotherapy to inhibit progression or treat invasive disease. The available evidence supports a shift in the immune composition of IPMNs during neoplastic progression. Although low-grade lesions contain a high proportion of effector T cells, high-grade IPMNs, and IPMNs with an associated invasive carcinoma lose the T-cell infiltrate and are characterised by a predominance of immunosuppressive elements. Several possible therapeutic strategies emerge from this analysis that are unique to IPMNs and its microbiome.

Identifiants

DOI: 10.1016/S2468-1253(22)00235-7 PMID: 36057265 PMC: PMC9844533
pubmed: 36057265
pii: S2468-1253(22)00235-7
doi: 10.1016/S2468-1253(22)00235-7
pmc: PMC9844533
mid: NIHMS1859816
pii:
doi:

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

1141-1150

Subventions

Organisme : NCI NIH HHS
ID : P30 CA006973
Pays : United States
Organisme : NCI NIH HHS
ID : R37 CA238435
Pays : United States

Informations de copyright

Copyright © 2022 Elsevier Ltd. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of interests The Department of General and Pancreatic Surgery at the University of Verona received funding from the Italian Ministry of Health (Grant FIMP-CUP J38D19000690001). GP reports funding from Associazione Italiana Ricerca sul Cancro (IG 2021-26201). RH is under a license agreement between Thrive Earlier Detection, a subsidiary of Exact Sciences, and the Johns Hopkins University. AVM's research in tumour immunology is funded through the National Institutes of Health Method To Extend Research in Time award (R37CA238435), and AVM is an inventor who has the following pending or issued patents: WO2018183603A1 (PCT/US2018/025027) and US9757457B2.

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Auteurs

Tommaso Pollini (T)

Division of Surgical Oncology, Department of Surgery, University of California San Francisco, San Francisco, CA, USA; Department of General and Pancreatic Surgery, The Pancreas Institute, Section of Pathology University of Verona, Verona, Italy.

Volcan Adsay (V)

Department of Pathology, Koç University Hospital and Koç University Research Center for Translational Medicine, Istanbul, Turkey.

Gabriele Capurso (G)

Department of Pancreatobiliary Endoscopy and Endosonography, Pancreas Translational and Clinical Research Center, IRCCS San Raffaele, Milan, Italy.

Marco Dal Molin (M)

Department of Surgery, University of Maryland Medical Center, Baltimore, MD, USA.

Irene Esposito (I)

Department of Pathology, Heinrich Heine University and University Hospital of Düsseldorf, Düsseldorf, Germany.

Ralph Hruban (R)

Department of Pathology, the Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, Baltimore, MA, USA.

Claudio Luchini (C)

Department of Diagnostics and Public Health, Section of Pathology University of Verona, Verona, Italy.

Laura Maggino (L)

Department of General and Pancreatic Surgery, The Pancreas Institute, Section of Pathology University of Verona, Verona, Italy.

Hanno Matthaei (H)

Department of Surgery, University Hospital of Bonn, Bonn, Germany.

Giovanni Marchegiani (G)

Department of General and Pancreatic Surgery, The Pancreas Institute, Section of Pathology University of Verona, Verona, Italy.

Aldo Scarpa (A)

Department of Diagnostics and Public Health, Section of Pathology University of Verona, Verona, Italy.

Laura D Wood (LD)

Department of Pathology, the Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, Baltimore, MA, USA.

Claudio Bassi (C)

Department of General and Pancreatic Surgery, The Pancreas Institute, Section of Pathology University of Verona, Verona, Italy.

Roberto Salvia (R)

Department of General and Pancreatic Surgery, The Pancreas Institute, Section of Pathology University of Verona, Verona, Italy.

Mari Mino-Kenudson (M)

Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.

Ajay V Maker (AV)

Division of Surgical Oncology, Department of Surgery, University of California San Francisco, San Francisco, CA, USA. Electronic address: ajay.maker@ucsf.edu.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › The tumour immune microenvironment and...
questionsmedicales.fr › Tumeurs › Tumeurs par type histologique › Tumeurs épithéliales épidermoïdes et glandulaires › Tumeurs kystiques, mucineuses et séreuses › Adénocarcinome mucineux › The tumour immune microenvironment and...
questionsmedicales.fr › Maladies endocriniennes › Tumeurs des glandes endocrines › Tumeurs du pancréas › Carcinome du canal pancréatique › The tumour immune microenvironment and...
questionsmedicales.fr › Maladies endocriniennes › Tumeurs des glandes endocrines › Tumeurs du pancréas › The tumour immune microenvironment and...
questionsmedicales.fr › Système digestif › Pancréas › Conduits pancréatiques › The tumour immune microenvironment and...
questionsmedicales.fr › Environnement et santé publique › Environnement › Écosystème › Biodiversité › Biote › Microbiote › The tumour immune microenvironment and...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Microenvironnement cellulaire › Microenvironnement tumoral › The tumour immune microenvironment and...