Involvement of strawberry notch homologue 1 in neurite outgrowth of cortical neurons.
Nex-Cre
cortical neurons
cortical plate
neurite growth
strawberry notch
Journal
Development, growth & differentiation
ISSN: 1440-169X
Titre abrégé: Dev Growth Differ
Pays: Japan
ID NLM: 0356504
Informations de publication
Date de publication:
Sep 2022
Sep 2022
Historique:
revised:
15
06
2022
received:
04
06
2022
accepted:
15
06
2022
pubmed:
4
9
2022
medline:
1
10
2022
entrez:
3
9
2022
Statut:
ppublish
Résumé
When the regulation of axonal and dendritic growth is altered, the neuronal network becomes disordered, which may contribute to the development of psychiatric disorders. Some genome analyses have suggested relationships between mutations in strawberry notch homologue 1 (SBNO1) and neurodevelopmental disorders. However, the function of SBNO1 has not yet been reported. Here, SBNO1 expression pattern during the development of the cerebral cortex in mice was examined. SBNO1 was strongly expressed in the cortical plate and its expression was maintained at a low level during the postnatal stage. CRISPR/Cas9-based knockout of Sbno1 in Neuro2A cultured cells showed delayed growth of neurites. A cortical neuron-specific conditional knockout mouse was constructed, which resulted in hypotrophy of axon bundles and dendrites in cortical neurons. Thus, when mutated, SBNO1 is a candidate gene for psychiatric diseases, such as schizophrenia, as suggested by human genome studies.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
379-394Informations de copyright
© 2022 Japanese Society of Developmental Biologists.
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