Prenatal and child vitamin D levels and allergy and asthma in childhood.
Journal
Pediatric research
ISSN: 1530-0447
Titre abrégé: Pediatr Res
Pays: United States
ID NLM: 0100714
Informations de publication
Date de publication:
05 2023
05 2023
Historique:
received:
18
10
2021
accepted:
29
07
2022
revised:
27
07
2022
medline:
12
5
2023
pubmed:
4
9
2022
entrez:
3
9
2022
Statut:
ppublish
Résumé
Early-life vitamin D deficiency may impair immune system development contributing to allergy and asthma onset. Findings from prospective studies are inconsistent. To examine whether maternal and child vitamin D levels are associated with allergic and asthma-related symptoms throughout childhood in a Spanish birth cohort. 25-Hydroxyvitamin D A total of 19% of mothers and 24% of children had deficient 25(OH)D Child 25(OH)D In this Spanish birth cohort, with a total of 19% of mothers and 24% of children with deficient levels of vitamin D, higher child vitamin D at 4 years of age was associated with reduced odds of atopic eczema up to 9 years. There was also some evidence that higher maternal and child vitamin D levels reduced the prevalence of late-onset wheezing. Although these findings need replication, they may imply optimal vitamin D levels at pre-school age to prevent atopic eczema.
Sections du résumé
BACKGROUND
Early-life vitamin D deficiency may impair immune system development contributing to allergy and asthma onset. Findings from prospective studies are inconsistent.
OBJECTIVE
To examine whether maternal and child vitamin D levels are associated with allergic and asthma-related symptoms throughout childhood in a Spanish birth cohort.
METHODS
25-Hydroxyvitamin D
RESULTS
A total of 19% of mothers and 24% of children had deficient 25(OH)D
CONCLUSION
Child 25(OH)D
IMPACT
In this Spanish birth cohort, with a total of 19% of mothers and 24% of children with deficient levels of vitamin D, higher child vitamin D at 4 years of age was associated with reduced odds of atopic eczema up to 9 years. There was also some evidence that higher maternal and child vitamin D levels reduced the prevalence of late-onset wheezing. Although these findings need replication, they may imply optimal vitamin D levels at pre-school age to prevent atopic eczema.
Identifiants
pubmed: 36057646
doi: 10.1038/s41390-022-02256-9
pii: 10.1038/s41390-022-02256-9
doi:
Substances chimiques
Vitamin D
1406-16-2
Vitamins
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1745-1751Informations de copyright
© 2022. The Author(s), under exclusive licence to the International Pediatric Research Foundation, Inc.
Références
Holick, M. Vitamin D deficiency. N. Engl. J. Med. 357, 266–281 (2007).
doi: 10.1056/NEJMra070553
pubmed: 17634462
Manios, Y. et al. A systematic review of vitamin D status in southern European countries. Eur. J. Nutr. 57, 2001–2036 (2018).
doi: 10.1007/s00394-017-1564-2
pubmed: 29090332
Saraf, R., Morton, S. M. B., Camargo, C. A. & Grant, C. C. Global summary of maternal and newborn vitamin D status – a systematic review. Matern. Child Nutr. 12, 647–668 (2016).
doi: 10.1111/mcn.12210
pubmed: 26373311
Briceno Noriega, D. S. H. Vitamin D and allergy susceptibility during gestation and early life. Nutrients 13, 1015 (2021).
doi: 10.3390/nu13031015
pubmed: 33801051
pmcid: 8003945
Baïz, N. et al. Cord serum 25-hydroxyvitamin D and risk of early childhood transient wheezing and atopic dermatitis. J. Allergy Clin. Immunol. 133, 147–153 (2014).
doi: 10.1016/j.jaci.2013.05.017
pubmed: 23810764
Boguniewicz, M. & Leung, D. Y. M. Atopic dermatitis: a disease of altered skin barrier and immune dysregulation. Immunol. Rev. 242, 233–246 (2011).
doi: 10.1111/j.1600-065X.2011.01027.x
pubmed: 21682749
pmcid: 3122139
Chiu, C. Y. et al. Maternal vitamin D levels are inversely related to allergic sensitization and atopic diseases in early childhood. Pediatr. Allergy Immunol. 26, 337–343 (2015).
doi: 10.1111/pai.12384
pubmed: 25847488
Hollams, E. M. et al. Vitamin D and atopy and asthma phenotypes in children: a longitudinal cohort study. Eur. Respir. J. 38, 1320–1327 (2011).
doi: 10.1183/09031936.00029011
pubmed: 21565922
Hollams, E. M. et al. Vitamin D over the first decade and susceptibility to childhood allergy and asthma. J. Allergy Clin. Immunol. 139, 472–481 (2017).
doi: 10.1016/j.jaci.2016.07.032
pubmed: 27726947
Maslova, E. et al. Predicted vitamin D status in mid-pregnancy and child allergic disease. Pediatr. Allergy Immunol. 25, 706–713 (2014).
doi: 10.1111/pai.12295
pubmed: 25348236
Wegienka, G. et al. Association between vitamin D levels and allergy-related outcomes vary by race and other factors. J. Allergy Clin. Immunol. 136, 1309–1314 (2015).
doi: 10.1016/j.jaci.2015.04.017
pubmed: 26078105
pmcid: 4640935
Pacheco-González, R. M., García-Marcos, L. & Morales, E. Prenatal vitamin D status and respiratory and allergic outcomes in childhood: a meta-analysis of observational studies. Pediatr. Allergy Immunol. 29, 243–253 (2018).
doi: 10.1111/pai.12876
pubmed: 29444346
Morales, E. et al. Maternal vitamin D status in pregnancy and risk of lower respiratory tract infections, wheezing, and asthma in offspring. Epidemiology 23, 64–71 (2012).
doi: 10.1097/EDE.0b013e31823a44d3
pubmed: 22082994
Mensink-Bout, S. M. et al. Maternal and neonatal 25-hydroxyvitamin D concentrations and school-age lung function, asthma and allergy. The Generation R Study. Clin. Exp. Allergy 49, 900–910 (2019).
doi: 10.1111/cea.13384
pubmed: 30866115
pmcid: 6850458
Berents, T. L. et al. Vitamin D levels and atopic eczema in infancy and early childhood in Norway: a cohort study. Br. J. Dermatol. 175, 95–101 (2016).
doi: 10.1111/bjd.14537
pubmed: 26972308
Tolppanen, A. M. et al. Prospective association of 25-hydroxyvitamin D3 and D2 with childhood lung function, asthma, wheezing, and flexural dermatitis. Epidemiology 24, 310–319 (2013).
doi: 10.1097/EDE.obo13e318280dd5e
pubmed: 23377091
Gale, C. R. et al. Maternal vitamin D status during pregnancy and child outcomes. Eur. J. Clin. Nutr. 62, 68–77 (2008).
doi: 10.1038/sj.ejcn.1602680
pubmed: 17311057
Tian, Y. et al. Maternal serum 25‐hydroxyvitamin D levels and infant atopic dermatitis: a prospective cohort study. Pediatr. Allergy Immunol. 32, 1637–1645 (2021).
Chiu, C. Y. et al. Low cord blood vitamin D levels are associated with increased milk sensitization in early childhood. Pediatr. Allergy Immunol. 25, 767–772 (2014).
doi: 10.1111/pai.12304
pubmed: 25389018
Guxens, M. et al. Cohort Profile: The INMA — INfancia y Medio Ambiente —(Environment and Childhood) Project. Int J. Epidemiol. 41, 930–940 (2012).
doi: 10.1093/ije/dyr054
pubmed: 21471022
Bunyavanich, S. et al. Prenatal, perinatal, and childhood vitamin D exposure and their association with childhood allergic rhinitis and allergic sensitization. J. Allergy Clin. Immunol. 137, 1063–1070 (2016).
doi: 10.1016/j.jaci.2015.11.031
pubmed: 26874366
pmcid: 4826831
GmbH Laboratories. Instruction Manual BIO-RAD. (25(OH)-Vitamin D3 by HPLC (GmbH Laboratories, Munchen, Germany, 2003).
Buckland, G. et al. Adherence to the mediterranean diet and risk of coronary heart disease in the spanish EPIC cohort study. Am. J. Epidemiol. 170, 1518–1529 (2009).
doi: 10.1093/aje/kwp282
pubmed: 19903723
Camargo, C. A. et al. Randomized trial of vitamin D supplementation for winter-related atopic dermatitis in children. J. Allergy Clin. Immunol. 134, 831–835.e1 (2014).
doi: 10.1016/j.jaci.2014.08.002
pubmed: 25282565
Lara-Corrales, I. et al. Vitamin D level and supplementation in pediatric atopic dermatitis: a randomized controlled trial. J. Cutan. Med. Surg. 23, 44–49 (2019).
doi: 10.1177/1203475418805744
pubmed: 30336685
Galli, E. et al. Serum vitamin D levels and vitamin D supplementation do not correlate with the severity of chronic eczema in children. Eur. Ann. Allergy Clin. Immunol. 47, 41–47 (2015).
pubmed: 25781193
Rodriguez, A. et al. Associations of maternal circulating 25-hydroxyvitamin D3 concentration with pregnancy and birth outcomes. BJOG Int J. Obstet. Gynaecol. 122, 1695–1704 (2015).
doi: 10.1111/1471-0528.13074
Giustina, A. et al. Controversies in vitamin D: a statement from the Third International Conference. JBMR Plus 4, 1–13 (2020).
doi: 10.1002/jbm4.10417
Feng, H. et al. In utero exposure to 25-hydroxyvitamin D and risk of childhood asthma, wheeze, and respiratory tract infections: a meta-analysis of birth cohort studies. J. Allergy Clin. Immunol. 139, 1508–1517 (2017).
doi: 10.1016/j.jaci.2016.06.065
pubmed: 27639938
Wolsk, H. M. et al. Prenatal vitamin D supplementation reduces risk of asthma/recurrent wheeze in early childhood: a combined analysis of two randomized controlled trials. PLoS One 12, 1–15 (2017).
doi: 10.1371/journal.pone.0186657
Litonjua, A. A. et al. Six-year follow-up of a trial of antenatal vitamin D for asthma reduction. N. Engl. J. Med. 382, 525–533 (2020).
doi: 10.1056/NEJMoa1906137
pubmed: 32023372
pmcid: 7444088
Anderson, L. N. et al. Vitamin D exposure during pregnancy, but not early childhood, is associated with risk of childhood wheezing. J. Dev. Orig. Health Dis. 6, 308–316 (2015).
doi: 10.1017/S2040174415001063
pubmed: 25885931
Bønnelykke, K. et al. Maternal 17q21 genotype influences prenatal vitamin D effects on offspring asthma/recurrent wheeze. Eur. Respir. J. 2, 2000–2012 (2021).
Niforou, A., Konstantinidou, V. & Naska, A. Genetic variants shaping inter-individual differences in response to dietary intakes — a narrative review of the case of vitamins. Front Nutr. 7, 558598 (2020).
doi: 10.3389/fnut.2020.558598
pubmed: 33335908
pmcid: 7736113
Hill, D. L. et al. Immune system development varies according to age, location, and anemia in African children. Sci. Transl. Med. 12, 9522 (2020).
doi: 10.1126/scitranslmed.aaw9522
Moon, R. J. et al. Tracking of 25-hydroxyVitamin D status during pregnancy: the importance of Vitamin D supplementation. Am. J. Clin. Nutr. 102, 1081–1087 (2015).
doi: 10.3945/ajcn.115.115295
pubmed: 26399867
Mirzakhani, H., Al-Garawi, A., Weiss, S. T. & Litonjua, A. A. Vitamin D and the development of allergic disease: how important is it? Clin. Exp. Allergy 45, 114–125 (2015).
doi: 10.1111/cea.12430
pubmed: 25307157
pmcid: 4369152
Dirks, N. F. et al. The when, what & how of measuring vitamin D metabolism in clinical medicine. Nutrients 10, 482 (2018).
doi: 10.3390/nu10040482
pubmed: 29652819
pmcid: 5946267
Lensmeyer, G. L., Wiebe, D. A., Binkley, N. & Drezner, M. K. HPLC method for 25-hydroxyvitamin D measurement: comparison with contemporary assays. Clin. Chem. 52, 1120–1126 (2006).
doi: 10.1373/clinchem.2005.064956
pubmed: 16574756
Roth, H. J., Schmidt-Gayk, H., Weber, H. & Niederau, C. Accuracy and clinical implications of seven 25-hydroxyvitamin D methods compared with liquid chromatography-tandem mass spectrometry as a reference. Ann. Clin. Biochem. 45, 153–159 (2008).
doi: 10.1258/acb.2007.007091
pubmed: 18325178
Garcia-Aymerich, J. et al. Phenotyping asthma, rhinitis and eczema in MeDALL population-based birth cohorts: an allergic comorbidity cluster. Allergy Eur. J. Allergy Clin. Immunol. 70, 973–984 (2015).
doi: 10.1111/all.12640