Nocturnal nasal high-flow oxygen therapy in elderly patients with concomitant chronic obstructive pulmonary disease and obstructive sleep apnea.
COPD
High-flow nasal cannula
Nocturnal hypoxemia
Obstructive sleep apnea
Overlap syndrome
Journal
Sleep & breathing = Schlaf & Atmung
ISSN: 1522-1709
Titre abrégé: Sleep Breath
Pays: Germany
ID NLM: 9804161
Informations de publication
Date de publication:
06 2023
06 2023
Historique:
received:
20
03
2022
accepted:
19
08
2022
revised:
23
07
2022
medline:
31
5
2023
pubmed:
4
9
2022
entrez:
3
9
2022
Statut:
ppublish
Résumé
The coexistence of obstructive sleep apnea (OSA) and chronic obstructive pulmonary disease (COPD) is known as "overlap syndrome" (OS). Patients with OS are usually older than patients with OSA alone, suffer from more profound oxygen desaturation during the obstructive events often accompanied by sustained nocturnal hypoventilation. Although oxygen-enriched positive airway pressure (PAP) is the treatment of choice in these patients, this therapy is often poorly tolerated particularly by the elderly. The aim of this study was to assess the usefulness of nocturnal oxygen therapy via nasal high flow (NHF-OT) as a possible alternative to PAP in patients with OS. Patients > 65 years old with OS and nocturnal respiratory failure (time spent below SaO A total of 40 patients were enrolled in the study. NHF-OT significantly reduced the apnea-hypopnea index (AHI) in all patients compared to baseline and COT. The mean basal AHI was 25.4 ± 8.6. During COT and NHF-OT, the AHI was 19.4 ± 7 and 5.4 ± 4.6, respectively (P < 0.001) and 19 patients reached an AHI < 5 during NHF-OT. The mean nocturnal SaO In elderly patients with OS, nocturnal treatment with NHF-OT significantly reduces obstructive episodes and improves oxygenation. As the treatment is generally well tolerated compared to PAP, NHF-OT may be a possible alternative therapy in this subgroup of patients.
Identifiants
pubmed: 36057738
doi: 10.1007/s11325-022-02702-2
pii: 10.1007/s11325-022-02702-2
pmc: PMC10227143
doi:
Substances chimiques
Oxygen
S88TT14065
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1049-1055Informations de copyright
© 2022. The Author(s).
Références
Eur J Intern Med. 2019 Nov;69:e15-e16
pubmed: 31494020
COPD. 2020 Apr;17(2):175-183
pubmed: 32183538
Respir Care. 2010 Apr;55(4):408-13
pubmed: 20406507
Sleep Breath. 2022 Jun;26(2):783-791
pubmed: 34383275
COPD. 2017 Jun;14(3):346-350
pubmed: 28459282
N Engl J Med. 2020 Sep 17;383(12):1129-1138
pubmed: 32937046
Ther Adv Chronic Dis. 2020 May 13;11:2040622320920106
pubmed: 32489572
J Clin Med. 2020 Feb 17;9(2):
pubmed: 32079251
Respir Care. 2013 Oct;58(10):1621-4
pubmed: 23513246
Am J Respir Crit Care Med. 2014 Aug 1;190(3):282-8
pubmed: 25003980
Lancet. 2014 Feb 22;383(9918):736-47
pubmed: 23910433
Minerva Anestesiol. 2013 Dec;79(12):1344-55
pubmed: 23857440
COPD. 2019 Dec;16(5-6):368-377
pubmed: 31656111
Sci Rep. 2020 May 22;10(1):8524
pubmed: 32444630
Sleep. 1997 Jun;20(6):406-22
pubmed: 9302725
Am J Respir Crit Care Med. 2007 Jul 15;176(2):194-200
pubmed: 17363769
Respir Care. 2005 May;50(5):604-9
pubmed: 15871753
Chest. 2010 Mar;137(3):521-8
pubmed: 19952061
Int J Chron Obstruct Pulmon Dis. 2018 Apr 16;13:1195-1205
pubmed: 29713153
Chest. 2017 Dec;152(6):1318-1326
pubmed: 28442310
Respir Care. 2019 Jun;64(6):735-742
pubmed: 31110041
Sleep Med Rev. 2018 Feb;37:45-59
pubmed: 28110857
Chronic Obstr Pulm Dis. 2017 Aug 15;4(4):279-286
pubmed: 29354672
Ann Am Thorac Soc. 2019 Jan;16(1):71-81
pubmed: 30372124
Thorax. 2016 Aug;71(8):759-61
pubmed: 27015801
Sleep. 2020 Dec 14;43(12):
pubmed: 32575113
Am J Respir Crit Care Med. 1995 Jan;151(1):82-6
pubmed: 7812577
Clin Chest Med. 1985 Dec;6(4):651-61
pubmed: 2935359
J Clin Sleep Med. 2013 Aug 15;9(8):767-72
pubmed: 23946706
Thorax. 2006 May;61(5):435-9
pubmed: 16490766
Eur Respir J. 2005 Jul;26(1):153-61
pubmed: 15994402
J Clin Sleep Med. 2008 Apr 15;4(2):157-71
pubmed: 18468315
Chest. 2021 Aug;160(2):701-717
pubmed: 33610579
FASEB Bioadv. 2021 Jun 11;3(9):683-693
pubmed: 34485837
Ther Adv Chronic Dis. 2015 Sep;6(5):273-85
pubmed: 26336596