Potential role of dynein-related genes in the etiology of male infertility: A systematic review and a meta-analysis.
MMAF
asthenozoospermia
dynein
male infertility
Journal
Andrology
ISSN: 2047-2927
Titre abrégé: Andrology
Pays: England
ID NLM: 101585129
Informations de publication
Date de publication:
Nov 2022
Nov 2022
Historique:
revised:
21
08
2022
received:
14
04
2022
accepted:
28
08
2022
pubmed:
5
9
2022
medline:
19
10
2022
entrez:
4
9
2022
Statut:
ppublish
Résumé
The dynein-related genes may have a role in the etiology of male infertility, particularly in cases of impaired sperm motility. The goal of this review is to compile a list of the most important dynein-related candidate genes that may contribute to male factor infertility. Databases were searched using the keywords "dynein," "male," "infertility," and by applying strict inclusion criteria. A meta-analysis was also performed by using the eligible case-control studies. The odd ratios (ORs), the Z-test score, and the level of significance were determined using a fixed model with a p value of 0.05. Funnel plots were used to check for publication bias. There were 35 studies that met the inclusion criteria. There were a total of 15 genes responsible for the production of dynein structural proteins, the production of dynein assembling factors, and potentially associated with male infertility. A total of five case-control studies were eligible for inclusion in the meta-analysis. Variants in the dynein-related genes were linked to an increased the risk of male infertility (OR = 21.52, 95% confidence interval 8.34-55.50, Z test = 6.35, p < 0.05). The percentage of heterogeneity, I The results from the present review illustrate that pathogenic variants in genes both for dynein synthesis and for dynein assembly factors could be associated with isolated cases of male infertility without any other symptoms. The genes addressed in this study, which are involved in both the production and assembly of dynein, could be used as molecular targets for future research into the etiology of sperm motility problems.
Sections du résumé
BACKGROUND
The dynein-related genes may have a role in the etiology of male infertility, particularly in cases of impaired sperm motility.
OBJECTIVES
The goal of this review is to compile a list of the most important dynein-related candidate genes that may contribute to male factor infertility.
MATERIALS AND METHODS
Databases were searched using the keywords "dynein," "male," "infertility," and by applying strict inclusion criteria. A meta-analysis was also performed by using the eligible case-control studies. The odd ratios (ORs), the Z-test score, and the level of significance were determined using a fixed model with a p value of 0.05. Funnel plots were used to check for publication bias.
RESULTS
There were 35 studies that met the inclusion criteria. There were a total of 15 genes responsible for the production of dynein structural proteins, the production of dynein assembling factors, and potentially associated with male infertility. A total of five case-control studies were eligible for inclusion in the meta-analysis. Variants in the dynein-related genes were linked to an increased the risk of male infertility (OR = 21.52, 95% confidence interval 8.34-55.50, Z test = 6.35, p < 0.05). The percentage of heterogeneity, I
DISCUSSION
The results from the present review illustrate that pathogenic variants in genes both for dynein synthesis and for dynein assembly factors could be associated with isolated cases of male infertility without any other symptoms.
CONCLUSIONS
The genes addressed in this study, which are involved in both the production and assembly of dynein, could be used as molecular targets for future research into the etiology of sperm motility problems.
Substances chimiques
Dyneins
EC 3.6.4.2
Types de publication
Journal Article
Meta-Analysis
Review
Systematic Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1484-1499Informations de copyright
© 2022 American Society of Andrology and European Academy of Andrology.
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