Characterization of Nasco grape pomace-loaded nutriosomes and their neuroprotective effects in the MPTP mouse model of Parkinson's disease.
antioxidant activity
grape pomace extract
nanotechnology
neurodegeneration
neuroprotection
tyrosine hydoxylase
Journal
Frontiers in pharmacology
ISSN: 1663-9812
Titre abrégé: Front Pharmacol
Pays: Switzerland
ID NLM: 101548923
Informations de publication
Date de publication:
2022
2022
Historique:
received:
04
05
2022
accepted:
04
07
2022
entrez:
5
9
2022
pubmed:
6
9
2022
medline:
6
9
2022
Statut:
epublish
Résumé
Grape pomaces have recently received great attention for their richness in polyphenols, compounds known to exert anti-inflammatory and antioxidant effects. These pomaces, however, have low brain bioavailability when administered orally due to their extensive degradation in the gastrointestinal tract. To overcome this problem, Nasco pomace extract was incorporated into a novel nanovesicle system called nutriosomes, composed of phospholipids (S75) and water-soluble maltodextrin (Nutriose
Identifiants
pubmed: 36059998
doi: 10.3389/fphar.2022.935784
pii: 935784
pmc: PMC9428270
doi:
Types de publication
Journal Article
Langues
eng
Pagination
935784Informations de copyright
Copyright © 2022 Parekh, Serra, Allaw, Perra, Marongiu, Tolle, Pinna, Casu, Manconi, Caboni, Manzoni and Morelli.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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