Biophysical characterisation of the Bcl-x pre-mRNA and binding specificity of the ellipticine derivative GQC-05: Implication for alternative splicing regulation.
G-quadruplex
NMR
alternative splicing
apoptosis
circular dichroism
ellipticine
Journal
Frontiers in molecular biosciences
ISSN: 2296-889X
Titre abrégé: Front Mol Biosci
Pays: Switzerland
ID NLM: 101653173
Informations de publication
Date de publication:
2022
2022
Historique:
received:
13
05
2022
accepted:
18
07
2022
entrez:
5
9
2022
pubmed:
6
9
2022
medline:
6
9
2022
Statut:
epublish
Résumé
The BCL2L1 gene expresses two isoforms of Bcl-x protein via the use of either of two alternative 5' splice sites (5'ss) in exon 2. These proteins have antagonistic actions, Bcl-X
Identifiants
pubmed: 36060245
doi: 10.3389/fmolb.2022.943105
pii: 943105
pmc: PMC9428248
doi:
Types de publication
Journal Article
Langues
eng
Pagination
943105Informations de copyright
Copyright © 2022 Bhogadia, Stone, Del Villar Guerra, Muskett, Ghosh, Taladriz-Sender, Burley, Eperon, Hudson and Dominguez.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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