Proteasomal subunit depletions differentially affect germline integrity in

19S regulatory particle C. elegans germ line meiosis proteasome

Journal

Frontiers in cell and developmental biology
ISSN: 2296-634X
Titre abrégé: Front Cell Dev Biol
Pays: Switzerland
ID NLM: 101630250

Informations de publication

Date de publication:
2022
Historique:
received: 21 03 2022
accepted: 08 07 2022
entrez: 5 9 2022
pubmed: 6 9 2022
medline: 6 9 2022
Statut: epublish

Résumé

The 26S proteasome is a multi-subunit protein complex that is canonically known for its ability to degrade proteins in cells and maintain protein homeostasis. Non-canonical or non-proteolytic roles of proteasomal subunits exist but remain less well studied. We provide characterization of germline-specific functions of different 19S proteasome regulatory particle (RP) subunits in

Identifiants

pubmed: 36060813
doi: 10.3389/fcell.2022.901320
pii: 901320
pmc: PMC9428126
doi:

Types de publication

Journal Article

Langues

eng

Pagination

901320

Informations de copyright

Copyright © 2022 Fernando, Quesada-Candela, Murray, Ugoaru, Yanowitz and Allen.

Déclaration de conflit d'intérêts

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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Auteurs

Lourds Michelle Fernando (LM)

Department of Biology, Howard University, Washington, DC, United States.

Cristina Quesada-Candela (C)

Magee-Womens Research Institute and Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States.

Makaelah Murray (M)

Department of Biology, Howard University, Washington, DC, United States.

Caroline Ugoaru (C)

Department of Biology, Howard University, Washington, DC, United States.

Judith L Yanowitz (JL)

Magee-Womens Research Institute and Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States.
Departments of Developmental Biology, Microbiology, and Molecular Genetics, The Hillman Cancer Center, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States.

Anna K Allen (AK)

Department of Biology, Howard University, Washington, DC, United States.

Classifications MeSH