Bored at home?-A systematic review on the effect of environmental enrichment on the welfare of laboratory rats and mice.
abnormal behavior
animal behavior
animal welfare
boredom
enriched environment
impoverished environment
laboratory animals (mouse and rat)
Journal
Frontiers in veterinary science
ISSN: 2297-1769
Titre abrégé: Front Vet Sci
Pays: Switzerland
ID NLM: 101666658
Informations de publication
Date de publication:
2022
2022
Historique:
received:
18
03
2022
accepted:
19
07
2022
entrez:
5
9
2022
pubmed:
6
9
2022
medline:
6
9
2022
Statut:
epublish
Résumé
Boredom is an emotional state that occurs when an individual has nothing to do, is not interested in the surrounding, and feels dreary and in a monotony. While this condition is usually defined for humans, it may very well describe the lives of many laboratory animals housed in small, barren cages. To make the cages less monotonous, environmental enrichment is often proposed. Although housing in a stimulating environment is still used predominantly as a luxury good and for treatment in preclinical research, enrichment is increasingly recognized to improve animal welfare. To gain insight into how stimulating environments influence the welfare of laboratory rodents, we conducted a systematic review of studies that analyzed the effect of enriched environment on behavioral parameters of animal well-being. Remarkably, a considerable number of these parameters can be associated with symptoms of boredom. Our findings show that a stimulating living environment is essential for the development of natural behavior and animal welfare of laboratory rats and mice alike, regardless of age and sex. Conversely, confinement and under-stimulation has potentially detrimental effects on the mental and physical health of laboratory rodents. We show that boredom in experimental animals is measurable and does not have to be accepted as inevitable.
Identifiants
pubmed: 36061113
doi: 10.3389/fvets.2022.899219
pmc: PMC9435384
doi:
Types de publication
Systematic Review
Langues
eng
Pagination
899219Informations de copyright
Copyright © 2022 Mieske, Hobbiesiefken, Fischer-Tenhagen, Heinl, Hohlbaum, Kahnau, Meier, Wilzopolski, Butzke, Rudeck, Lewejohann and Diederich.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Behav Brain Res. 2010 Jul 29;211(1):96-104
pubmed: 20230861
Behav Brain Res. 2010 Mar 17;208(1):231-6
pubmed: 19962407
Physiol Behav. 2007 Oct 22;92(3):422-8
pubmed: 17174361
Biol Sex Differ. 2016 Jul 26;7:34
pubmed: 27468347
Behav Processes. 1983 Mar;8(1):1-20
pubmed: 24923604
Neurosci Lett. 2017 Aug 24;656:37-42
pubmed: 28729075
PLoS One. 2016 Jan 28;11(1):e0147595
pubmed: 26820978
Brain Res. 2007 Jul 30;1160:91-101
pubmed: 17572392
Physiol Rep. 2020 Oct;8(20):e14609
pubmed: 33118684
Mol Neurobiol. 2021 Jan;58(1):348-361
pubmed: 32939692
J Neurosci. 2003 Dec 3;23(35):10999-1007
pubmed: 14657156
Neurosci Lett. 2015 Sep 25;605:39-43
pubmed: 26275348
Dev Psychobiol. 2017 Apr;59(3):390-399
pubmed: 28181216
Arzneimittelforschung. 2010;60(6):307-14
pubmed: 20648919
Stroke. 1996 Feb;27(2):324-6
pubmed: 8571431
Dev Psychobiol. 1980 Sep;13(5):527-44
pubmed: 7409333
Behav Brain Res. 2012 Oct 1;234(2):175-83
pubmed: 22732260
Front Zool. 2015 Aug 24;12 Suppl 1:S17
pubmed: 26816516
Exp Neurol. 2017 Aug;294:12-18
pubmed: 28457905
Physiol Behav. 2004 May;81(3):443-53
pubmed: 15135016
Elife. 2016 Mar 03;5:
pubmed: 26939790
Physiol Behav. 2001 Oct;74(3):313-20
pubmed: 11714494
Sci Rep. 2018 Jul 12;8(1):10529
pubmed: 30002484
PLoS One. 2015 Jul 08;10(7):e0131709
pubmed: 26154768
Front Immunol. 2021 Jul 28;12:695859
pubmed: 34394087
Lab Anim. 2002 Jul;36(3):243-70
pubmed: 12144738
Low Urin Tract Symptoms. 2021 Jul;13(3):400-409
pubmed: 33648020
Neurosci Lett. 2008 Oct 10;443(3):223-7
pubmed: 18687379
BMC Biol. 2022 Jan 13;20(1):15
pubmed: 35022024
Pharmacol Biochem Behav. 2017 Jul;158:49-56
pubmed: 28601602
Behav Brain Res. 2018 Nov 1;353:40-50
pubmed: 29966601
Nat Commun. 2021 Jun 23;12(1):3892
pubmed: 34162876
Elife. 2018 Oct 26;7:
pubmed: 30362941
Front Neurosci. 2009 Nov 10;3:50
pubmed: 20582277
Psychopharmacology (Berl). 2009 Apr;203(3):561-70
pubmed: 19005643
Brain Res Bull. 2021 May;170:98-105
pubmed: 33592274
Behav Brain Res. 2016 May 15;305:186-90
pubmed: 26876137
Syst Rev. 2012 Feb 09;1:7
pubmed: 22588008
Behav Processes. 2006 Nov 1;73(3):360-6
pubmed: 16987609
PLoS One. 2012;7(11):e49180
pubmed: 23155462
Prog Neuropsychopharmacol Biol Psychiatry. 2013 Jan 10;40:252-9
pubmed: 23085072
Front Neurosci. 2019 Mar 14;13:107
pubmed: 30930726
J Neural Transm (Vienna). 2013 May;120(5):829-43
pubmed: 23254925
Anim Welf. 2020 Feb;29(1):19-26
pubmed: 32226239
Int J Dev Neurosci. 2019 Apr;73:32-40
pubmed: 30590115
Eur J Neurosci. 2004 Sep;20(5):1341-7
pubmed: 15341605
Behav Brain Res. 2009 Jan 30;197(1):125-37
pubmed: 18786573
Front Behav Neurosci. 2016 Oct 13;10:195
pubmed: 27790100
J Appl Anim Welf Sci. 2002;5(2):87-109
pubmed: 12738579
Pharmacol Biochem Behav. 2011 Dec;100(2):237-43
pubmed: 21924284
Behav Brain Res. 2006 Sep 25;172(2):299-306
pubmed: 16806520
Neuropharmacology. 2012 Sep;63(4):635-41
pubmed: 22634364
Nat Rev Neurosci. 2000 Dec;1(3):191-8
pubmed: 11257907
Nat Rev Neurosci. 2009 Dec;10(12):861-72
pubmed: 19888284
Physiol Behav. 2015 Feb;139:97-103
pubmed: 25446220
Behav Brain Res. 2021 Aug 27;412:113432
pubmed: 34186145
Trends Neurosci. 2001 Apr;24(4):207-11
pubmed: 11250003
Drug Alcohol Depend. 2018 Oct 1;191:343-347
pubmed: 30176547
Nat Rev Neurosci. 2019 Apr;20(4):235-245
pubmed: 30723309
Neuroscience. 2021 May 1;461:80-90
pubmed: 33662528
Physiol Behav. 2015 Apr 1;142:131-6
pubmed: 25666307
Physiol Behav. 2022 May 15;249:113771
pubmed: 35247441
J Am Assoc Lab Anim Sci. 2014 Mar;53(2):161-7
pubmed: 24602542
Brain Res Bull. 2021 Dec;177:172-180
pubmed: 34624462
PLoS One. 2021 Dec 23;16(12):e0261876
pubmed: 34941949
PLoS One. 2013 Dec 23;8(12):e83578
pubmed: 24376721
Neurobiol Dis. 2011 Jun;42(3):530-8
pubmed: 21406231
Physiol Behav. 2019 Oct 15;210:112638
pubmed: 31381902
Physiol Behav. 1986;36(6):1139-45
pubmed: 3725918
Psychol Rep. 1991 Dec;69(3 Pt 2):1139-46
pubmed: 1792282
Behav Processes. 1998 Jan;42(1):61-72
pubmed: 24897196
Behav Brain Res. 2011 Nov 20;225(1):85-90
pubmed: 21767574
Neuroscience. 2017 Jun 3;352:296-305
pubmed: 28412502
Behav Processes. 2014 Oct;108:57-64
pubmed: 25256162
Assessment. 2013 Feb;20(1):68-85
pubmed: 21903683
J Comp Physiol Psychol. 1973 Nov;85(2):373-82
pubmed: 4756915
Prog Neuropsychopharmacol Biol Psychiatry. 2017 Jul 3;77:65-74
pubmed: 28390969
Behav Neurosci. 2019 Oct;133(5):478-488
pubmed: 31343201
Acta Neurobiol Exp (Wars). 2019;79(4):374-385
pubmed: 31885394
Lab Anim. 2006 Oct;40(4):392-9
pubmed: 17018210
Behav Processes. 2010 Oct;85(2):172-80
pubmed: 20637270
Pharmacol Biochem Behav. 2018 Mar;166:35-41
pubmed: 29407873
Pharmacol Biochem Behav. 2015 Nov;138:20-5
pubmed: 26368843
Front Behav Neurosci. 2018 Oct 26;12:232
pubmed: 30416435
Front Neural Circuits. 2021 Dec 03;15:758939
pubmed: 34924964
Nature. 2014 May 15;509(7500):282-3
pubmed: 24834516
Basic Clin Neurosci. 2018 Jul-Aug;9(4):241-250
pubmed: 30519382
Dev Psychobiol. 1999 Dec;35(4):328-42
pubmed: 10573572
Exp Neurol. 2007 Apr;204(2):714-9
pubmed: 17331503
Clin Sci (Lond). 2017 Oct 12;131(20):2525-2532
pubmed: 29026002
Pharmacol Biochem Behav. 2008 Mar;89(1):85-93
pubmed: 18096212
Pharmacol Biochem Behav. 2020 May;192:172907
pubmed: 32179027
Sports Med. 2001;31(12):863-73
pubmed: 11665913
Pharmacol Biochem Behav. 2011 Nov;100(1):25-32
pubmed: 21777607
Pharmacol Biochem Behav. 2012 Apr;101(2):278-87
pubmed: 22248860
Physiol Behav. 2019 Sep 1;208:112564
pubmed: 31145918
Psychopharmacology (Berl). 2021 Oct;238(10):2999-3012
pubmed: 34333673
Am J Drug Alcohol Abuse. 2020 Sep 2;46(5):553-564
pubmed: 32811189
Animals (Basel). 2022 Feb 09;12(4):
pubmed: 35203123
PLoS One. 2013;8(3):e58460
pubmed: 23505511
Lab Anim. 2017 Apr;51(2):160-169
pubmed: 27307423
Anim Cogn. 2022 Feb;25(1):103-120
pubmed: 34322771
Eur Arch Psychiatry Clin Neurosci. 2015 Sep;265(6):483-96
pubmed: 25236183
J Neurosci. 2001 Jul 15;21(14):5272-80
pubmed: 11438602
BMJ. 2005 Dec 24;331(7531):1503-5
pubmed: 16373730
Front Behav Neurosci. 2021 Jun 15;15:676416
pubmed: 34211378
Neuropsychobiology. 2022;81(3):225-236
pubmed: 35026760
Front Behav Neurosci. 2015 Nov 12;9:303
pubmed: 26617502
J Exp Anal Behav. 1995 May;63(3):313-29
pubmed: 7751835
Behav Pharmacol. 2011 Aug;22(4):347-53
pubmed: 21673566
Behav Processes. 2010 Mar;83(3):242-6
pubmed: 19944132
J Physiol Paris. 1997 May-Oct;91(3-5):105-11
pubmed: 9403783
Sci Rep. 2019 Dec 30;9(1):20305
pubmed: 31889107
Lab Anim. 2020 Apr;54(2):150-158
pubmed: 32050843
Cogn Affect Behav Neurosci. 2022 Aug;22(4):703-721
pubmed: 33846950
Int J Neurosci. 2014 May;124(5):369-76
pubmed: 24102158
J Am Assoc Lab Anim Sci. 2008 Nov;47(6):25-31
pubmed: 19049249
ILAR J. 2005;46(2):106-17
pubmed: 15775020
Front Mol Neurosci. 2016 Aug 03;9:62
pubmed: 27536216
Neuroscience. 2011 Jun 16;184:88-96
pubmed: 21477638
Behav Brain Res. 2013 May 15;245:34-41
pubmed: 23428744
Clin Psychol Rev. 1997;17(5):567-77
pubmed: 9260041
Behav Brain Res. 2014 May 15;265:76-83
pubmed: 24569010
Physiol Behav. 1997 Nov;62(5):1019-28
pubmed: 9333195
Pharmacol Biochem Behav. 2012 Sep;102(3):434-41
pubmed: 22691868
Pharmacol Biochem Behav. 2017 Mar;154:20-30
pubmed: 28108176
Brain Behav. 2017 Jul 22;7(8):e00767
pubmed: 28828224
Science. 2014 Jul 4;345(6192):75-7
pubmed: 24994650