Adeno-associated virus 9 vector-mediated cardiac-selective expression of human secretory leukocyte protease inhibitor attenuates myocardial ischemia/reperfusion injury.
cardiac selective expression
cardioprotection
gene therapy
ischemic/reperfusion injury
secretory leukocyte protease inhibitor (SLPI)
Journal
Frontiers in cardiovascular medicine
ISSN: 2297-055X
Titre abrégé: Front Cardiovasc Med
Pays: Switzerland
ID NLM: 101653388
Informations de publication
Date de publication:
2022
2022
Historique:
received:
23
06
2022
accepted:
27
07
2022
entrez:
5
9
2022
pubmed:
6
9
2022
medline:
6
9
2022
Statut:
epublish
Résumé
Protease enzymes contribute to the initiation of cardiac remodeling and heart failure after myocardial ischemic/reperfusion (I/R) injury. Protease inhibitors attenuate protease activity and limit left ventricular dysfunction and remodeling. Previous studies showed the cardioprotective effect of secretory leukocyte protease inhibitor (SLPI) against I/R injury. However, overexpression of SLPI gene in cardiovascular diseases has only been investigated in an
Identifiants
pubmed: 36061560
doi: 10.3389/fcvm.2022.976083
pmc: PMC9437585
doi:
Types de publication
Journal Article
Langues
eng
Pagination
976083Informations de copyright
Copyright © 2022 Mongkolpathumrat, Nernpermpisooth, Kijtawornrat, Pikwong, Chouyratchakarn, Yodsheewan, Unajak and Kumphune.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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