Cardiac immune cell infiltration associates with abnormal lipid metabolism.
CD36
PET tracers
cardiac inflammation
eicosanoids
lipidomics
macrophage
Journal
Frontiers in cardiovascular medicine
ISSN: 2297-055X
Titre abrégé: Front Cardiovasc Med
Pays: Switzerland
ID NLM: 101653388
Informations de publication
Date de publication:
2022
2022
Historique:
received:
19
05
2022
accepted:
22
07
2022
entrez:
5
9
2022
pubmed:
6
9
2022
medline:
6
9
2022
Statut:
epublish
Résumé
CD36 mediates the uptake of long-chain fatty acids (FAs), a major energy substrate for the myocardium. Under excessive FA supply, CD36 can cause cardiac lipid accumulation and inflammation while its deletion reduces heart FA uptake and lipid content and increases glucose utilization. As a result, CD36 was proposed as a therapeutic target for obesity-associated heart disease. However, more recent reports have shown that CD36 deficiency suppresses myocardial flexibility in fuel preference between glucose and FAs, impairing tissue energy balance, while CD36 absence in tissue macrophages reduces efferocytosis and myocardial repair after injury. In line with the latter homeostatic functions, we had previously reported that CD36
Identifiants
pubmed: 36061565
doi: 10.3389/fcvm.2022.948332
pmc: PMC9428462
doi:
Types de publication
Journal Article
Langues
eng
Pagination
948332Subventions
Organisme : NHLBI NIH HHS
ID : R35 HL145212
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL045095
Pays : United States
Organisme : NIBIB NIH HHS
ID : P41 EB025815
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL118639
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK056341
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL133178
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK020541
Pays : United States
Informations de copyright
Copyright © 2022 Cifarelli, Kuda, Yang, Liu, Gross, Pietka, Heo, Sultan, Luehmann, Lesser, Ross, Goldberg, Gropler, Liu and Abumrad.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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