ATG5: A central autophagy regulator implicated in various human diseases.
ATG12-ATG5/ATG16L1
ATG5
ATG5 polymorphism
autophagosome
autophagy
Journal
Cell biochemistry and function
ISSN: 1099-0844
Titre abrégé: Cell Biochem Funct
Pays: England
ID NLM: 8305874
Informations de publication
Date de publication:
Oct 2022
Oct 2022
Historique:
revised:
16
08
2022
received:
20
06
2022
accepted:
19
08
2022
pubmed:
6
9
2022
medline:
4
10
2022
entrez:
5
9
2022
Statut:
ppublish
Résumé
Autophagy, an intracellular conserved degradative process, plays a central role in the renewal/recycling of a cell to maintain the homeostasis of nutrients and energy within the cell. ATG5, a key component of autophagy, regulates the formation of the autophagosome, a hallmark of autophagy. ATG5 binds with ATG12 and ATG16L1 resulting in E3 like ligase complex, which is necessary for autophagosome expansion. Available data suggest that ATG5 is indispensable for autophagy and has an imperative role in several essential biological processes. Moreover, ATG5 has also been demonstrated to possess autophagy-independent functions that magnify its significance and therapeutic potential. ATG5 interacts with various molecules for the execution of different processes implicated during physiological and pathological conditions. Furthermore, ATG5 genetic variants are associated with various ailments. This review discusses various autophagy-dependent and autophagy-independent roles of ATG5, highlights its various deleterious genetic variants reported until now, and various studies supporting it as a potential drug target.
Substances chimiques
ATG5 protein, human
0
Autophagy-Related Protein 12
0
Autophagy-Related Protein 5
0
Autophagy-Related Proteins
0
Microtubule-Associated Proteins
0
Ligases
EC 6.-
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
650-667Informations de copyright
© 2022 John Wiley & Sons Ltd.
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