Further sesquiterpenoids from Pittosporum qinlingense and their anti-inflammatory activity.
Anti-inflammatory activity
Pittosporum qinlingense
Sesquiterpenoid
β-D-fucopyranose
β-d-glucopyranose
Journal
Fitoterapia
ISSN: 1873-6971
Titre abrégé: Fitoterapia
Pays: Netherlands
ID NLM: 16930290R
Informations de publication
Date de publication:
Oct 2022
Oct 2022
Historique:
received:
05
06
2022
revised:
25
08
2022
accepted:
28
08
2022
pubmed:
6
9
2022
medline:
7
10
2022
entrez:
5
9
2022
Statut:
ppublish
Résumé
Four new sesquiterpenoid glycoside esters, Pitqinlingoside N-Q (1-4), together with eleven known metabolites (5-15), were isolated from 95% EtOH extract of the twigs, fruits and leaves of P. qinlingense. The structures of new compounds were elucidated on the basis of extensive spectroscopic analyses, including IR, UV, HRMS, NMR and electronic circular dichroism spectra. Unusal glycoside esters are characterized by the presence of polyacylated β-D-fucopyranosyl and β-d-glucopyranosyl units. Pitqinlingoside N (1), O (2), P (3), boscialin (5) and arvoside C (6) showed significant nitric oxide production inhibition in lipopolysaccharide (LPS)-induced BV-2 microglial cells with IC
Identifiants
pubmed: 36064153
pii: S0367-326X(22)00170-8
doi: 10.1016/j.fitote.2022.105292
pii:
doi:
Substances chimiques
Anti-Inflammatory Agents
0
Glycosides
0
Lipopolysaccharides
0
Plant Extracts
0
Sesquiterpenes
0
Nitric Oxide
31C4KY9ESH
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
105292Informations de copyright
Copyright © 2022 Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare no competing financial interest.