Translational development of ABCB5
ATP Binding Cassette Transporter, Subfamily B
/ genetics
Animals
Dermis
/ cytology
Diabetes Mellitus
/ genetics
Diabetic Foot
/ genetics
Humans
Ischemia
/ metabolism
Mesenchymal Stem Cell Transplantation
Mesenchymal Stem Cells
/ metabolism
Mice
Neovascularization, Pathologic
/ genetics
Neovascularization, Physiologic
/ physiology
RNA, Messenger
/ metabolism
Vascular Endothelial Growth Factor A
/ metabolism
Wound Healing
/ genetics
ABCB5
Advanced-therapy medicinal product
Angiogenesis
Chronic wound
Diabetic foot ulcer
Mesenchymal stem cells
Wound healing
Journal
Stem cell research & therapy
ISSN: 1757-6512
Titre abrégé: Stem Cell Res Ther
Pays: England
ID NLM: 101527581
Informations de publication
Date de publication:
05 09 2022
05 09 2022
Historique:
received:
31
03
2022
accepted:
25
06
2022
entrez:
5
9
2022
pubmed:
6
9
2022
medline:
9
9
2022
Statut:
epublish
Résumé
While rapid healing of diabetic foot ulcers (DFUs) is highly desirable to avoid infections, amputations and life-threatening complications, DFUs often respond poorly to standard treatment. GMP-manufactured skin-derived ABCB5 The angiogenic potential of ABCB5 Hypoxic incubation of ABCB5 The present observations identify GMP-manufactured ABCB5 ClinicalTrials.gov, NCT03267784, Registered 30 August 2017, https://clinicaltrials.gov/ct2/show/NCT03267784.
Sections du résumé
BACKGROUND
While rapid healing of diabetic foot ulcers (DFUs) is highly desirable to avoid infections, amputations and life-threatening complications, DFUs often respond poorly to standard treatment. GMP-manufactured skin-derived ABCB5
METHODS
The angiogenic potential of ABCB5
RESULTS
Hypoxic incubation of ABCB5
CONCLUSIONS
The present observations identify GMP-manufactured ABCB5
TRIAL REGISTRATION
ClinicalTrials.gov, NCT03267784, Registered 30 August 2017, https://clinicaltrials.gov/ct2/show/NCT03267784.
Identifiants
pubmed: 36064604
doi: 10.1186/s13287-022-03156-9
pii: 10.1186/s13287-022-03156-9
pmc: PMC9444095
doi:
Substances chimiques
ABCB5 protein, human
0
ABCB5 protein, mouse
0
ATP Binding Cassette Transporter, Subfamily B
0
RNA, Messenger
0
Vascular Endothelial Growth Factor A
0
Banques de données
ClinicalTrials.gov
['NCT03267784']
Types de publication
Journal Article
Randomized Controlled Trial
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
455Subventions
Organisme : NEI NIH HHS
ID : R24 EY028767
Pays : United States
Organisme : NEI NIH HHS
ID : RO1EY025794
Pays : United States
Organisme : NEI NIH HHS
ID : R24EY028767
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL161087
Pays : United States
Organisme : NHLBI NIH HHS
ID : 1R01HL161087
Pays : United States
Organisme : BLRD VA
ID : I01 BX000516
Pays : United States
Organisme : NEI NIH HHS
ID : R01 EY025794
Pays : United States
Organisme : RRD VA
ID : I01 RX000989
Pays : United States
Informations de copyright
© 2022. The Author(s).
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