Design and synthesis of benzimidazole derivatives as apoptosis-inducing agents by targeting Bcl-2 protein.
Anticancer drugs
Apoptosis
Bcl-2
Benzimidazole derivatives
Journal
Molecular diversity
ISSN: 1573-501X
Titre abrégé: Mol Divers
Pays: Netherlands
ID NLM: 9516534
Informations de publication
Date de publication:
Aug 2023
Aug 2023
Historique:
received:
30
07
2022
accepted:
26
08
2022
medline:
23
10
2023
pubmed:
7
9
2022
entrez:
6
9
2022
Statut:
ppublish
Résumé
Bcl-2, an anti-apoptotic protein, is a well-known and appealing cancer therapy target. Novel series of benzimidazole derivatives were synthesized and tested for their activity as Bcl-2 inhibitors on T98G glioblastoma, PC3 prostate, MCF-7 breast, and H69AR lung cancer cells. MTT assay was used to evaluate the cytotoxic effect. PI Annexin V Apoptosis Detection Kit was used to detect apoptosis. Expression levels of the Bcl-2 protein were examined by the Western blot analysis and qRT-PCR. All synthesized benzimidazole derivatives exhibited a cytotoxic effect on cancer cells with IC
Identifiants
pubmed: 36065037
doi: 10.1007/s11030-022-10524-3
pii: 10.1007/s11030-022-10524-3
doi:
Substances chimiques
Antineoplastic Agents
0
Benzimidazoles
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1703-1712Informations de copyright
© 2022. The Author(s), under exclusive licence to Springer Nature Switzerland AG.
Références
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