Assessing the Emergence of Resistance in vitro and Invivo: Linezolid Combined with Fosfomycin Against Fosfomycin-Sensitive and Resistant

fitness cost fosfomycin linezolid resistance virulence

Journal

Infection and drug resistance
ISSN: 1178-6973
Titre abrégé: Infect Drug Resist
Pays: New Zealand
ID NLM: 101550216

Informations de publication

Date de publication:
2022
Historique:
received: 08 06 2022
accepted: 20 08 2022
entrez: 6 9 2022
pubmed: 7 9 2022
medline: 7 9 2022
Statut: epublish

Résumé

We aimed to evaluate the synergistic effect of linezolid and fosfomycin on fosfomycin-sensitive and -resistant The synergistic effect of linezolid and fosfomycin was studied via in vitro checkerboard and static time-kill assays, as well as based on the in vivo survival rate and hemolymph load of a In vitro and in vivo data showed that linezolid combined with fosfomycin had a good synergistic effect on Linezolid combined with fosfomycin had a synergistic effect on both fosfomycin-sensitive and -resistant

Identifiants

pubmed: 36065277
doi: 10.2147/IDR.S377848
pii: 377848
pmc: PMC9440711
doi:

Types de publication

Journal Article

Langues

eng

Pagination

4995-5010

Informations de copyright

© 2022 Li et al.

Déclaration de conflit d'intérêts

The authors report no conflicts of interest in this work.

Références

Antibiotics (Basel). 2021 Feb 22;10(2):
pubmed: 33671753
Antibiotics (Basel). 2021 Sep 27;10(10):
pubmed: 34680753
Crit Care Med. 2018 Oct;46(10):1634-1642
pubmed: 29957707
Infect Drug Resist. 2018 Aug 08;11:1105-1117
pubmed: 30127628
Virulence. 2018 Dec 31;9(1):860-865
pubmed: 29726300
Diagn Microbiol Infect Dis. 2021 Feb;99(2):115241
pubmed: 33130503
Clin Microbiol Rev. 2019 Jan 30;32(2):
pubmed: 30700430
J Antimicrob Chemother. 2020 Aug 1;75(8):2173-2181
pubmed: 32357212
Antimicrob Agents Chemother. 2007 Apr;51(4):1287-92
pubmed: 17242144
J Antimicrob Chemother. 2012 Jun;67(6):1325-32
pubmed: 22378682
Antibiotics (Basel). 2021 Jul 19;10(7):
pubmed: 34356793
Helicobacter. 2021 Aug;26(4):e12808
pubmed: 33884706
Nat Med. 2006 May;12(5):515-7
pubmed: 16633349
Infect Drug Resist. 2021 Feb 24;14:639-649
pubmed: 33658805
J Antimicrob Chemother. 2018 Mar 1;73(3):709-719
pubmed: 29253153
PLoS Genet. 2018 Sep 4;14(9):e1007525
pubmed: 30180166
Int J Antimicrob Agents. 2020 Jul;56(1):105935
pubmed: 32156620
Nat Rev Microbiol. 2019 Jan;17(2):82-94
pubmed: 30337708
J Am Coll Cardiol. 2019 Nov 12;74(19):2435-2436
pubmed: 31699288
Front Microbiol. 2019 Aug 28;10:2001
pubmed: 31555237
Infect Drug Resist. 2019 Nov 12;12:3497-3505
pubmed: 31814738
Nat Microbiol. 2021 Jan;6(1):103-111
pubmed: 33106672
Evol Appl. 2015 Mar;8(3):273-83
pubmed: 25861385
Front Cell Infect Microbiol. 2021 Dec 22;11:782733
pubmed: 35004350
Pharmaceutics. 2021 Aug 31;13(9):
pubmed: 34575453
BMC Complement Altern Med. 2018 May 30;18(1):169
pubmed: 29848316
Biomed Res Int. 2016;2016:6413982
pubmed: 27366751
J Hosp Infect. 2018 Jul;99(3):346-355
pubmed: 29066140
Antibiotics (Basel). 2022 Mar 24;11(4):
pubmed: 35453188
Eur J Clin Pharmacol. 2022 Aug;78(8):1301-1310
pubmed: 35610318
mSphere. 2019 Feb 13;4(1):
pubmed: 30760612
Int J Med Microbiol. 2021 Feb;311(2):151477
pubmed: 33524636
Front Pharmacol. 2022 Jan 28;12:773994
pubmed: 35153743
Tuberculosis (Edinb). 2021 Jul;129:102091
pubmed: 34090078
J Glob Antimicrob Resist. 2020 Sep;22:78-83
pubmed: 32007618
Genome Biol. 2018 Jul 18;19(1):94
pubmed: 30021593
Front Microbiol. 2021 Dec 14;12:779885
pubmed: 34970238
J Antimicrob Chemother. 2020 Jul 1;75(7):1704-1711
pubmed: 32129849
Inflammation. 2021 Dec;44(6):2429-2447
pubmed: 34505975
J Antibiot (Tokyo). 2017 Feb;70(2):166-173
pubmed: 27756910
Pathogens. 2021 Nov 14;10(11):
pubmed: 34832638
Expert Rev Anti Infect Ther. 2022 Jan;20(1):33-43
pubmed: 34030567
Ann Transl Med. 2022 Feb;10(3):148
pubmed: 35284561
Diagn Microbiol Infect Dis. 2018 Jun;91(2):161-163
pubmed: 29496381
BMC Microbiol. 2020 Jun 15;20(1):162
pubmed: 32539684
Pharmacotherapy. 2019 Nov;39(11):1077-1094
pubmed: 31487056
Front Microbiol. 2021 Feb 09;11:605962
pubmed: 33633692
Nat Microbiol. 2021 Nov;6(11):1410-1423
pubmed: 34697460
Nat Rev Microbiol. 2017 Jul;15(7):382-383
pubmed: 28579609
Int J Antimicrob Agents. 2019 Jan;53(1):22-28
pubmed: 30268576
Antibiotics (Basel). 2021 Dec 17;10(12):
pubmed: 34943757
Pathol Biol (Paris). 2012 Apr;60(2):e9-14
pubmed: 19942376
Clin Infect Dis. 2004 Jan 1;38(1):155-6
pubmed: 14679466
Front Vet Sci. 2022 Feb 11;9:801800
pubmed: 35224081
Infect Drug Resist. 2019 Jul 11;12:2049-2057
pubmed: 31372012
Int J Med Microbiol. 2017 Dec;307(8):452-459
pubmed: 28986014
Emerg Infect Dis. 2017 Nov;23(11):1902-1904
pubmed: 29048285
J Microbiol Immunol Infect. 2017 Feb;50(1):55-61
pubmed: 25682237
Expert Opin Investig Drugs. 2009 Jul;18(7):921-44
pubmed: 19548851
Front Med (Lausanne). 2021 Sep 10;8:720647
pubmed: 34568377
J Antimicrob Chemother. 2007 Jan;59(1):28-34
pubmed: 17065188
Microbiol Spectr. 2021 Dec 22;9(3):e0087121
pubmed: 34851157
Eur J Clin Microbiol Infect Dis. 2018 Aug;37(8):1441-1448
pubmed: 29909468
BMC Genomics. 2019 Oct 22;20(1):761
pubmed: 31640552
J Microbiol Immunol Infect. 2020 Oct;53(5):731-738
pubmed: 30638785
Sci Rep. 2016 Jan 18;6:19262
pubmed: 26778774
Eur Rev Med Pharmacol Sci. 2020 Sep;24(18):9274-9281
pubmed: 33015768
mBio. 2020 Feb 11;11(1):
pubmed: 32047136
Front Microbiol. 2014 Nov 10;5:544
pubmed: 25426104
J Fungi (Basel). 2021 Nov 26;7(12):
pubmed: 34946994
Clin Infect Dis. 2015 Oct 15;61Suppl 3:S147-54
pubmed: 26409276
mBio. 2017 Feb 21;8(1):
pubmed: 28223450

Auteurs

Yaowen Li (Y)

Department of Basic and Clinical Pharmacology, School of Pharmacy, Anhui Medical University, Hefei, People's Republic of China.
Anhui Province Key Laboratory of Major Autoimmune Diseases, School of Pharmacy, Anhui Institute of Innovative Drugs, Anhui Medical University, Hefei, People's Republic of China.

Yu Peng (Y)

Department of Basic and Clinical Pharmacology, School of Pharmacy, Anhui Medical University, Hefei, People's Republic of China.
Anhui Province Key Laboratory of Major Autoimmune Diseases, School of Pharmacy, Anhui Institute of Innovative Drugs, Anhui Medical University, Hefei, People's Republic of China.

Na Zhang (N)

Department of Basic and Clinical Pharmacology, School of Pharmacy, Anhui Medical University, Hefei, People's Republic of China.
Anhui Province Key Laboratory of Major Autoimmune Diseases, School of Pharmacy, Anhui Institute of Innovative Drugs, Anhui Medical University, Hefei, People's Republic of China.

Huiping Liu (H)

Department of Basic and Clinical Pharmacology, School of Pharmacy, Anhui Medical University, Hefei, People's Republic of China.
Anhui Province Key Laboratory of Major Autoimmune Diseases, School of Pharmacy, Anhui Institute of Innovative Drugs, Anhui Medical University, Hefei, People's Republic of China.

Jun Mao (J)

Department of Basic and Clinical Pharmacology, School of Pharmacy, Anhui Medical University, Hefei, People's Republic of China.
Anhui Province Key Laboratory of Major Autoimmune Diseases, School of Pharmacy, Anhui Institute of Innovative Drugs, Anhui Medical University, Hefei, People's Republic of China.

Yisong Yan (Y)

Department of Pharmacy, Anhui College of Traditional Chinese Medicine, Wuhu, Anhui, People's Republic of China.

Shuaishuai Wang (S)

Department of Basic and Clinical Pharmacology, School of Pharmacy, Anhui Medical University, Hefei, People's Republic of China.
Anhui Province Key Laboratory of Major Autoimmune Diseases, School of Pharmacy, Anhui Institute of Innovative Drugs, Anhui Medical University, Hefei, People's Republic of China.

Guang Yang (G)

Department of Pharmacy, The Third People's Hospital of Tongling, Tongling, Anhui, People's Republic of China.

Yanyan Liu (Y)

Department of Infectious Diseases, The First Affiliated Hospital of Anhui Medical University, Hefei, People's Republic of China.

Jiabin Li (J)

Department of Infectious Diseases, The First Affiliated Hospital of Anhui Medical University, Hefei, People's Republic of China.

Xiaohui Huang (X)

Department of Basic and Clinical Pharmacology, School of Pharmacy, Anhui Medical University, Hefei, People's Republic of China.
Anhui Province Key Laboratory of Major Autoimmune Diseases, School of Pharmacy, Anhui Institute of Innovative Drugs, Anhui Medical University, Hefei, People's Republic of China.

Classifications MeSH