Disrupting Interleukin 12 Improves Microvascular Endothelial Function in Type 2 Diabetes Through ER Stress CHOP and Oxidative Stress Mechanisms.
ER stress
interleukin-12
microvascular endothelial dysfunction
oxidative stress
type 2 diabetes
Journal
Diabetes, metabolic syndrome and obesity : targets and therapy
ISSN: 1178-7007
Titre abrégé: Diabetes Metab Syndr Obes
Pays: New Zealand
ID NLM: 101515585
Informations de publication
Date de publication:
2022
2022
Historique:
received:
06
04
2022
accepted:
08
07
2022
entrez:
6
9
2022
pubmed:
7
9
2022
medline:
7
9
2022
Statut:
epublish
Résumé
Vascular endothelial dysfunction is well established in type 2 diabetes. Interleukin-12 (IL-12) and endoplasmic reticulum (ER) stress are up-regulated in type 2 diabetic patients and animal models of type 2 diabetes. However, the role and underlying mechanisms of IL-12 and the ER stress CHOP in endothelial dysfunction are not fully understood. We generated double knockout mice between db The results showed that GTT was improved in db-/db Using a genetic approach, these findings provide evidence that IL-12 and ER stress CHOP play a significant role in microvascular endothelial dysfunction in type 2 diabetes.
Identifiants
pubmed: 36065460
doi: 10.2147/DMSO.S369488
pii: 369488
pmc: PMC9440700
doi:
Types de publication
Journal Article
Langues
eng
Pagination
2633-2642Subventions
Organisme : NHLBI NIH HHS
ID : R01 HL150014
Pays : United States
Informations de copyright
© 2022 Radwan et al.
Déclaration de conflit d'intérêts
The authors report no conflicts of interest in this work.
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