Tetraplegia is associated with increased hypoxic ventilatory response during nonrapid eye movement sleep.

Eye Movements Humans Hypoxia Male Quadriplegia Sleep / physiology Spinal Cord Injuries / complications
acute intermittent hypoxia hypoxia long-term facilitation plasticity spinal cord injury

Journal

Physiological reports
ISSN: 2051-817X
Titre abrégé: Physiol Rep
Pays: United States
ID NLM: 101607800

Informations de publication

Date de publication:
09 2022
Historique:
revised: 19 08 2022
received: 03 09 2021
accepted: 21 08 2022
entrez: 6 9 2022
pubmed: 7 9 2022
medline: 9 9 2022
Statut: ppublish

Résumé

People with cervical spinal cord injury (SCI) are likely to experience chronic intermittent hypoxia while sleeping. The physiological effects of intermittent hypoxia on the respiratory system during spontaneous sleep in individuals with chronic cervical SCI are unknown. We hypothesized that individuals with cervical SCI would demonstrate higher short- and long-term ventilatory responses to acute intermittent hypoxia (AIH) exposure than individuals with thoracic SCI during sleep. Twenty participants (10 with cervical SCI [9 male] and 10 with thoracic SCI [6 male]) underwent an AIH and sham protocol during sleep. During the AIH protocol, each participant experienced 15 episodes of isocapnic hypoxia using mixed gases of 100% nitrogen (N

Identifiants

DOI: 10.14814/phy2.15455 PMID: 36065854 PMC: PMC9446393
pubmed: 36065854
doi: 10.14814/phy2.15455
pmc: PMC9446393
doi:

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, U.S. Gov't, Non-P.H.S.

Langues

eng

Sous-ensembles de citation

IM

Pagination

e15455

Subventions

Organisme : NHLBI NIH HHS
ID : HL130552
Pays : United States
Organisme : CSRD VA
ID : I01 CX001201
Pays : United States
Organisme : NHLBI NIH HHS
ID : R21 HL140447
Pays : United States

Informations de copyright

© 2022 The Authors. Physiological Reports published by Wiley Periodicals LLC on behalf of The Physiological Society and the American Physiological Society.

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Auteurs

Sarah Vaughan (S)

Department of Medicine, John D. Dingell VA Medical Center, Detroit, Michigan, USA.
Department of Internal Medicine, Wayne State University, Detroit, Michigan, USA.
ORCID: 0000-0001-7962-4526

Abdulghani Sankari (A)

Department of Medicine, John D. Dingell VA Medical Center, Detroit, Michigan, USA.
Department of Internal Medicine, Wayne State University, Detroit, Michigan, USA.
Department of Medical Education, Ascension Providence Hospital, Southfield, Michigan, USA.
ORCID: 0000-0002-2400-3375

Sean Carroll (S)

Department of Medicine, John D. Dingell VA Medical Center, Detroit, Michigan, USA.
Department of Internal Medicine, Wayne State University, Detroit, Michigan, USA.

Mehdi Eshraghi (M)

Department of Medicine, John D. Dingell VA Medical Center, Detroit, Michigan, USA.
Department of Internal Medicine, Wayne State University, Detroit, Michigan, USA.

Harold Obiakor (H)

Department of Medicine, John D. Dingell VA Medical Center, Detroit, Michigan, USA.
Department of Internal Medicine, Wayne State University, Detroit, Michigan, USA.

Hossein Yarandi (H)

Department of Internal Medicine, Wayne State University, Detroit, Michigan, USA.

Susmita Chowdhuri (S)

Department of Medicine, John D. Dingell VA Medical Center, Detroit, Michigan, USA.
Department of Internal Medicine, Wayne State University, Detroit, Michigan, USA.

Anan Salloum (A)

Department of Medicine, John D. Dingell VA Medical Center, Detroit, Michigan, USA.
Department of Internal Medicine, Wayne State University, Detroit, Michigan, USA.

M Safwan Badr (MS)

Department of Medicine, John D. Dingell VA Medical Center, Detroit, Michigan, USA.
Department of Internal Medicine, Wayne State University, Detroit, Michigan, USA.

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Classifications MeSH

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