Delivering optimal renal replacement therapy to critically ill patients with acute kidney injury.

Acute kidney injury Clinical trials Intensive care unit Renal replacement therapy

Journal

Intensive care medicine
ISSN: 1432-1238
Titre abrégé: Intensive Care Med
Pays: United States
ID NLM: 7704851

Informations de publication

Date de publication:
10 2022
Historique:
received: 04 05 2022
accepted: 29 07 2022
pubmed: 7 9 2022
medline: 15 9 2022
entrez: 6 9 2022
Statut: ppublish

Résumé

Critical illness is often complicated by acute kidney injury (AKI). In patients with severe AKI, renal replacement therapy (RRT) is deployed to address metabolic dysfunction and volume excess until kidney function recovers. This review is intended to provide a comprehensive update on key aspects of RRT prescription and delivery to critically ill patients. Recently completed trials have enhanced the evidence base regarding several RRT practices, most notably the timing of RRT initiation and anticoagulation for continuous therapies. Better evidence is still needed to clarify several aspects of care including optimal targets for ultrafiltration and effective strategies for RRT weaning and discontinuation.

Identifiants

pubmed: 36066597
doi: 10.1007/s00134-022-06851-6
pii: 10.1007/s00134-022-06851-6
doi:

Types de publication

Journal Article Review Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1368-1381

Informations de copyright

© 2022. Springer-Verlag GmbH Germany, part of Springer Nature.

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Auteurs

Ron Wald (R)

Division of Nephrology, St. Michael's Hospital and the University of Toronto, 61 Queen Street East, 9-140, Toronto, ON, M5C 2T2, Canada. Ron.wald@unityhealth.to.
Li Ka Shing Knowledge Institute of St. Michael's Hospital, Toronto, ON, Canada. Ron.wald@unityhealth.to.

William Beaubien-Souligny (W)

Division of Nephrology, Centre Hospitalier de L'Université de Montréal, Montréal, QC, Canada.

Rahul Chanchlani (R)

Division of Pediatric Nephrology, Department of Pediatrics, McMaster University, Hamilton, ON, Canada.

Edward G Clark (EG)

Division of Nephrology, Department of Medicine, University of Ottawa, Ottawa, ON, Canada.

Javier A Neyra (JA)

Division of Nephrology, University of Alabama at Birmingham, Birmingham, AL, USA.

Marlies Ostermann (M)

Department of Critical Care Medicine, Guys and St. Thomas Hospital, London, UK.

Samuel A Silver (SA)

Division of Nephrology, Kingston Health Sciences Center, Queen's University, Kingston, ON, Canada.

Suvi Vaara (S)

Division of Intensive Care Medicine, Department of Anesthesiology, Intensive Care and Pain Medicine, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.

Alexander Zarbock (A)

Department of Anesthesiology, Intensive Care and Pain Medicine, Muenster, Germany.

Sean M Bagshaw (SM)

Department of Critical Care Medicine, University of Alberta and Alberta Health Services, Edmonton, AB, Canada.

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