Genome-wide meta-analysis for Alzheimer's disease cerebrospinal fluid biomarkers.

Alzheimer Disease / pathology Amyloid beta-Peptides / cerebrospinal fluid Apolipoproteins E / genetics Biomarkers / cerebrospinal fluid Cell Cycle Proteins Humans Peptide Fragments / cerebrospinal fluid tau Proteins / cerebrospinal fluid
Alzheimer’s disease Amyloid-beta Cerebrospinal fluid GWAS Tau

Journal

Acta neuropathologica
ISSN: 1432-0533
Titre abrégé: Acta Neuropathol
Pays: Germany
ID NLM: 0412041

Informations de publication

Date de publication:
11 2022
Historique:
received: 16 02 2022
accepted: 07 06 2022
revised: 18 05 2022
pubmed: 7 9 2022
medline: 12 10 2022
entrez: 6 9 2022
Statut: ppublish

Résumé

Amyloid-beta 42 (Aβ42) and phosphorylated tau (pTau) levels in cerebrospinal fluid (CSF) reflect core features of the pathogenesis of Alzheimer's disease (AD) more directly than clinical diagnosis. Initiated by the European Alzheimer & Dementia Biobank (EADB), the largest collaborative effort on genetics underlying CSF biomarkers was established, including 31 cohorts with a total of 13,116 individuals (discovery n = 8074; replication n = 5042 individuals). Besides the APOE locus, novel associations with two other well-established AD risk loci were observed; CR1 was shown a locus for Aβ42 and BIN1 for pTau. GMNC and C16orf95 were further identified as loci for pTau, of which the latter is novel. Clustering methods exploring the influence of all known AD risk loci on the CSF protein levels, revealed 4 biological categories suggesting multiple Aβ42 and pTau related biological pathways involved in the etiology of AD. In functional follow-up analyses, GMNC and C16orf95 both associated with lateral ventricular volume, implying an overlap in genetic etiology for tau levels and brain ventricular volume.

Identifiants

DOI: 10.1007/s00401-022-02454-z PMID: 36066633 PMC: PMC9547780
pubmed: 36066633
doi: 10.1007/s00401-022-02454-z
pii: 10.1007/s00401-022-02454-z
pmc: PMC9547780
doi:

Substances chimiques

Amyloid beta-Peptides 0
Apolipoproteins E 0
Biomarkers 0
Cell Cycle Proteins 0
GMNC protein, human 0
Peptide Fragments 0
tau Proteins 0

Types de publication

Journal Article Meta-Analysis Research Support, Non-U.S. Gov't Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

821-842

Subventions

Organisme : NIA NIH HHS
ID : R01 AG044546
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG064877
Pays : United States
Organisme : NIA NIH HHS
ID : RF1 AG053303
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG015801
Pays : United States
Organisme : NIA NIH HHS
ID : U01 AG058922
Pays : United States
Organisme : NIA NIH HHS
ID : RF1 AG058501
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG064614
Pays : United States

Informations de copyright

© 2022. The Author(s).

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Auteurs

Iris E Jansen (IE)

Alzheimer Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC Location VUmc, Amsterdam, The Netherlands. i.e.jansen@vu.nl.
Amsterdam Neuroscience, Neurodegeneration, Amsterdam, The Netherlands. i.e.jansen@vu.nl.
Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, VU Amsterdam, Amsterdam, The Netherlands. i.e.jansen@vu.nl.
ORCID: 0000-0003-1901-8131

Sven J van der Lee (SJ)

Alzheimer Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC Location VUmc, Amsterdam, The Netherlands.
Amsterdam Neuroscience, Neurodegeneration, Amsterdam, The Netherlands.
Section Genomics of Neurodegenerative Diseases and Aging, Human Genetics, Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc, Amsterdam, The Netherlands.
ORCID: 0000-0003-1606-8643

Duber Gomez-Fonseca (D)

Department of Psychiatry, Washington University School of Medicine, St Louis, MO, USA.
NeuroGenomics and Informatics, Washington University School of Medicine, St Louis, MO, USA.
Hope Center for Neurological Disorders, Washington University School of Medicine, St Louis, MO, USA.

Itziar de Rojas (I)

Research Center and Memory Clinic, Ace Alzheimer Center Barcelona, Universitat Internacional de Catalunya, Barcelona, Spain.
CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.
ORCID: 0000-0002-2148-381X

Maria Carolina Dalmasso (MC)

Division of Neurogenetics and Molecular Psychiatry, Department of Psychiatry and Psychotherapy, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
Neurosciences and Complex Systems Unit (ENyS), CONICET, Hospital El Cruce, National University A. Jauretche (UNAJ), Florencio Varela, Argentina.

Benjamin Grenier-Boley (B)

Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1167 - RID-AGE / Labex DISTALZ - Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement, F-59000, Lille, France.

Anna Zettergren (A)

Neuropsychiatric Epidemiology Unit, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, Centre for Ageing and Health (AGECAP) at the University of Gothenburg, Gothenburg, Sweden.
ORCID: 0000-0002-7182-8417

Aniket Mishra (A)

University of Bordeaux, Inserm, Bordeaux Population Health Research Center, Team VINTAGE, UMR 1219, 33000, Bordeaux, France.

Muhammad Ali (M)

Department of Psychiatry, Washington University School of Medicine, St Louis, MO, USA.
NeuroGenomics and Informatics, Washington University School of Medicine, St Louis, MO, USA.
Hope Center for Neurological Disorders, Washington University School of Medicine, St Louis, MO, USA.
ORCID: 0000-0002-1399-6631

Victor Andrade (V)

Division of Neurogenetics and Molecular Psychiatry, Department of Psychiatry and Psychotherapy, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
Department of Neurodegenerative Diseases and Geriatric Psychiatry, University Hospital Bonn, Medical Faculty, Bonn, Germany.

Céline Bellenguez (C)

Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1167 - RID-AGE / Labex DISTALZ - Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement, F-59000, Lille, France.

Luca Kleineidam (L)

Division of Neurogenetics and Molecular Psychiatry, Department of Psychiatry and Psychotherapy, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
Department of Neurodegenerative Diseases and Geriatric Psychiatry, University Hospital Bonn, Medical Faculty, Bonn, Germany.
German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.

Fahri Küçükali (F)

Complex Genetics of Alzheimer's Disease Group, VIB Center for Molecular Neurology, VIB, Antwerp, Belgium.
Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium.
ORCID: 0000-0002-3835-9639

Yun Ju Sung (YJ)

Department of Psychiatry, Washington University School of Medicine, St Louis, MO, USA.
NeuroGenomics and Informatics, Washington University School of Medicine, St Louis, MO, USA.
Hope Center for Neurological Disorders, Washington University School of Medicine, St Louis, MO, USA.

Niccolo Tesí (N)

Alzheimer Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC Location VUmc, Amsterdam, The Netherlands.
Amsterdam Neuroscience, Neurodegeneration, Amsterdam, The Netherlands.
Section Genomics of Neurodegenerative Diseases and Aging, Human Genetics, Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc, Amsterdam, The Netherlands.

Ellen M Vromen (EM)

Alzheimer Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC Location VUmc, Amsterdam, The Netherlands.
Amsterdam Neuroscience, Neurodegeneration, Amsterdam, The Netherlands.
ORCID: 0000-0001-7774-5500

Douglas P Wightman (DP)

Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, VU Amsterdam, Amsterdam, The Netherlands.

Daniel Alcolea (D)

CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.
Sant Pau Memory Unit, Department of Neurology, Institut d'Investigacions Biomèdiques Sant Pau - Hospital de Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain.
ORCID: 0000-0002-3819-3245

Montserrat Alegret (M)

Research Center and Memory Clinic, Ace Alzheimer Center Barcelona, Universitat Internacional de Catalunya, Barcelona, Spain.
CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.
ORCID: 0000-0002-8164-9500

Ignacio Alvarez (I)

Memory Disorders Unit, Department of Neurology, Hospital Universitari Mutua de Terrassa, Terrassa, Spain.
Fundació per a la Recerca Biomèdica i Social Mútua de Terrassa, Terrassa, Spain.

Philippe Amouyel (P)

Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1167 - RID-AGE / Labex DISTALZ - Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement, F-59000, Lille, France.

Lavinia Athanasiu (L)

NORMENT Centre, Institute of Clinical Medicine, University of Oslo and Division of Mental Health, Oslo, Norway.

Shahram Bahrami (S)

NORMENT Centre, Institute of Clinical Medicine, University of Oslo and Division of Mental Health, Oslo, Norway.

Henri Bailly (H)

Université Paris Cité, EA4468, Maladie d'Alzheimer, F-75013 Paris, France.

Olivia Belbin (O)

CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.
Sant Pau Memory Unit, Department of Neurology, Institut d'Investigacions Biomèdiques Sant Pau - Hospital de Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain.

Sverre Bergh (S)

The Research-Centre for Age-Related Functional Decline and Disease, Innlandet Hospital Trust, Brumunddal, Norway.
Norwegian National Centre for Ageing and Health, Vestfold Hospital Trust, Tønsberg, Norway.

Lars Bertram (L)

Lübeck Interdisciplinary Platform for Genome Analytics, University of Lübeck, Lübeck, Germany.
ORCID: 0000-0002-0108-124X

Geert Jan Biessels (GJ)

Department of Neurology, UMC Utrecht Brain Center, Utrecht, The Netherlands.
ORCID: 0000-0001-6862-2496

Kaj Blennow (K)

Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.
Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden.

Rafael Blesa (R)

CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.
Sant Pau Memory Unit, Department of Neurology, Institut d'Investigacions Biomèdiques Sant Pau - Hospital de Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain.

Mercè Boada (M)

Research Center and Memory Clinic, Ace Alzheimer Center Barcelona, Universitat Internacional de Catalunya, Barcelona, Spain.
CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.

Anne Boland (A)

Université Paris-Saclay, CEA, Centre National de Recherche en Génomique Humaine, 91057, Evry, France.

Katharina Buerger (K)

German Center for Neurodegenerative Diseases (DZNE, Munich), Munich, Germany.
Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Munich, Germany.

Ángel Carracedo (Á)

Grupo de Medicina Xenómica, Centro Nacional de Genotipado (CEGEN-PRB3-ISCIII), Universidade de Santiago de Compostela, Santiago de Compostela, Spain.
Fundación Pública Galega de Medicina Xenómica-CIBERER-IDIS, Santiago de Compostela, Spain.

Laura Cervera-Carles (L)

CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.
Sant Pau Memory Unit, Department of Neurology, Institut d'Investigacions Biomèdiques Sant Pau - Hospital de Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain.
ORCID: 0000-0003-2286-200X

Geneviève Chene (G)

University of Bordeaux, Inserm, Bordeaux Population Health Research Center, Team VINTAGE, UMR 1219, 33000, Bordeaux, France.
Department of Neurology, CHU de Bordeaux, 33000, Bordeaux, France.

Jurgen A H R Claassen (JAHR)

Radboudumc Alzheimer Center, Department of Geriatrics, Radboud University Medical Center, Nijmegen, The Netherlands.
Donders Center for Medical Neuroscience, Nijmegen, The Netherlands.
ORCID: 0000-0002-1778-8151

Stephanie Debette (S)

University of Bordeaux, Inserm, Bordeaux Population Health Research Center, Team VINTAGE, UMR 1219, 33000, Bordeaux, France.
Department of Neurology, CHU de Bordeaux, 33000, Bordeaux, France.
Department of Neurology, Boston University School of Medicine, Boston, MA, 2115, USA.

Jean-Francois Deleuze (JF)

Université Paris-Saclay, CEA, Centre National de Recherche en Génomique Humaine, 91057, Evry, France.

Peter Paul de Deyn (PP)

Department of Neurology and Alzheimer Center Groningen, University Medical Center Groningen, Groningen, The Netherlands.
ORCID: 0000-0002-2228-2964

Janine Diehl-Schmid (J)

Center for Cognitive Disorders, Department of Psychiatry and Psychotherapy, Klinikum rechts der Isar, Technical University of Munich, School of Medicine, Munich, Germany.
kbo-Inn-Salzach-Hospital, Wasserburg am Inn, Germany.

Srdjan Djurovic (S)

Department of Medical Genetics, Oslo University Hospital, Oslo, Norway.
Department of Clinical Science, NORMENT Centre, University of Bergen, Bergen, Norway.
ORCID: 0000-0002-8140-8061

Oriol Dols-Icardo (O)

CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.
Sant Pau Memory Unit, Department of Neurology, Institut d'Investigacions Biomèdiques Sant Pau - Hospital de Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain.

Carole Dufouil (C)

University of Bordeaux, Inserm, Bordeaux Population Health Research Center, Team VINTAGE, UMR 1219, 33000, Bordeaux, France.
Pôle de Santé Publique Centre Hospitalier Universitaire (CHU) de Bordeaux, Bordeaux, France.

Emmanuelle Duron (E)

Univerisité Paris-Saclay. Inserm 1178 MOODS, Paris, France.

Emrah Düzel (E)

German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany.
Institute of Cognitive Neurology and Dementia Research (IKND), Otto-von-Guericke University, Magdeburg, Germany.

Tormod Fladby (T)

Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
Department of Neurology, Akershus University Hospital, Lorenskog, Norway.

Juan Fortea (J)

CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.
Sant Pau Memory Unit, Department of Neurology, Institut d'Investigacions Biomèdiques Sant Pau - Hospital de Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain.

Lutz Frölich (L)

Department of Geriatric Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg, Germany.

Pablo García-González (P)

Research Center and Memory Clinic, Ace Alzheimer Center Barcelona, Universitat Internacional de Catalunya, Barcelona, Spain.
CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.
ORCID: 0000-0003-0125-5403

Maria Garcia-Martinez (M)

Cognitive Impairment Unit, Neurology Service, "Marqués de Valdecilla" University Hospital, Institute for Research "Marques de Valdecilla" (IDIVAL), University of Cantabria, Santander, Spain, and Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain.

Ina Giegling (I)

Division of General Psychiatry, Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria.

Oliver Goldhardt (O)

Center for Cognitive Disorders, Department of Psychiatry and Psychotherapy, Klinikum rechts der Isar, Technical University of Munich, School of Medicine, Munich, Germany.

Johan Gobom (J)

Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden.

Timo Grimmer (T)

Center for Cognitive Disorders, Department of Psychiatry and Psychotherapy, Klinikum rechts der Isar, Technical University of Munich, School of Medicine, Munich, Germany.

Annakaisa Haapasalo (A)

A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland.

Harald Hampel (H)

Alzheimer Precision Medicine (APM), Sorbonne University, AP-HP, Pitié-Salpêtrière Hospital, Paris, France.
Neurology Business Group, Eisai Inc, 100 Tice Blvd, Woodcliff Lake, NJ, 07677, USA.

Olivier Hanon (O)

Université Paris Cité, EA4468, Maladie d'Alzheimer, F-75013 Paris, France.
Service gériatrie, Centre Mémoire de Ressources et Recherches Ile de France-Broca, AP-HP, Hôpital Broca, F-75013, Paris, France.

Lucrezia Hausner (L)

Department of Geriatric Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg, Germany.

Stefanie Heilmann-Heimbach (S)

Institute of Human Genetics, University of Bonn, School of Medicine and University Hospital Bonn, 53127, Bonn, Germany.

Seppo Helisalmi (S)

Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland, Kuopio, Finland.

Michael T Heneka (MT)

Department of Neurodegenerative Diseases and Geriatric Psychiatry, University Hospital Bonn, Medical Faculty, Bonn, Germany.
German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.
ORCID: 0000-0003-4996-1630

Isabel Hernández (I)

Research Center and Memory Clinic, Ace Alzheimer Center Barcelona, Universitat Internacional de Catalunya, Barcelona, Spain.
CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.

Sanna-Kaisa Herukka (SK)

Department of Neurology, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland.

Henne Holstege (H)

Alzheimer Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC Location VUmc, Amsterdam, The Netherlands.
Amsterdam Neuroscience, Neurodegeneration, Amsterdam, The Netherlands.
Section Genomics of Neurodegenerative Diseases and Aging, Human Genetics, Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc, Amsterdam, The Netherlands.

Jonas Jarholm (J)

Department of Neurology, Akershus University Hospital, Lorenskog, Norway.

Silke Kern (S)

Neuropsychiatric Epidemiology Unit, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, Centre for Ageing and Health (AGECAP) at the University of Gothenburg, Gothenburg, Sweden.
Region Västra Götaland, Sahlgrenska University Hospital, Psychiatry, Cognition and Old Age Psychiatry Clinic, Gothenburg, Sweden.

Anne-Brita Knapskog (AB)

Department of Geriatric Medicine, Oslo University Hospital, Oslo, Norway.

Anne M Koivisto (AM)

Department of Neurology, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland.
Department of Neurology, Kuopio University Hospital, Kuopio, Finland.
Department of Neurology, Helsinki University Hospital, Helsinki, Finland.

Johannes Kornhuber (J)

Department of Psychiatry and Psychotherapy, Universitätsklinikum Erlangen, and Friedrich-Alexander Universität Erlangen-Nürnberg, Erlangen, Germany.
ORCID: 0000-0002-8096-3987

Teemu Kuulasmaa (T)

Bioinformatics Center, Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland.

Carmen Lage (C)

Cognitive Impairment Unit, Neurology Service, "Marqués de Valdecilla" University Hospital, Institute for Research "Marques de Valdecilla" (IDIVAL), University of Cantabria, Santander, Spain, and Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain.
Atlantic Fellow at the Global Brain Health Institute (GBHI) -, University of California, San Francisco, USA.

Christoph Laske (C)

German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany.
Section for Dementia Research, Hertie Institute for Clinical Brain Research and Department of Psychiatry and Psychotherapy, University of Tübingen, Tübingen, Germany.

Ville Leinonen (V)

Institute of Clinical Medicine, Neurosurgery, University of Eastern Finland, Kuopio, Finland.
Department of Neurosurgery, Kuopio University Hospital, Kuopio, Finland.
ORCID: 0000-0002-4282-4687

Piotr Lewczuk (P)

Department of Psychiatry and Psychotherapy, Universitätsklinikum Erlangen, and Friedrich-Alexander Universität Erlangen-Nürnberg, Erlangen, Germany.
Department of Neurodegeneration Diagnostics, Medical University of Białystok, Białystok, Poland.
ORCID: 0000-0002-8101-6535

Alberto Lleó (A)

CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.
Sant Pau Memory Unit, Department of Neurology, Institut d'Investigacions Biomèdiques Sant Pau - Hospital de Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain.

Adolfo López de Munain (AL)

CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.
Hospital Universitario Donostia-OSAKIDETZA, Donostia, Spain.
Instituto Biodonostia, San Sebastián, Spain.
University of The Basque Country, San Sebastian, Spain.

Sara Lopez-Garcia (S)

Cognitive Impairment Unit, Neurology Service, "Marqués de Valdecilla" University Hospital, Institute for Research "Marques de Valdecilla" (IDIVAL), University of Cantabria, Santander, Spain, and Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain.

Wolfgang Maier (W)

Department of Neurodegenerative Diseases and Geriatric Psychiatry, University Hospital Bonn, Medical Faculty, Bonn, Germany.

Marta Marquié (M)

Research Center and Memory Clinic, Ace Alzheimer Center Barcelona, Universitat Internacional de Catalunya, Barcelona, Spain.
CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.
ORCID: 0000-0002-0660-0950

Merel O Mol (MO)

Department of Neurology and Alzheimer Center Erasmus MC, Erasmus MC University Medical Center, Rotterdam, The Netherlands.
ORCID: 0000-0003-2533-2530

Laura Montrreal (L)

Research Center and Memory Clinic, Ace Alzheimer Center Barcelona, Universitat Internacional de Catalunya, Barcelona, Spain.

Fermin Moreno (F)

CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.
Hospital Universitario Donostia-OSAKIDETZA, Donostia, Spain.
Instituto Biodonostia, San Sebastián, Spain.

Sonia Moreno-Grau (S)

Research Center and Memory Clinic, Ace Alzheimer Center Barcelona, Universitat Internacional de Catalunya, Barcelona, Spain.
CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.

Gael Nicolas (G)

Department of Genetics and CNR-MAJ, Normandie Univ, UNIROUEN, Inserm U1245 and CHU Rouen, Rouen, France.

Markus M Nöthen (MM)

Institute of Human Genetics, University of Bonn, School of Medicine and University Hospital Bonn, 53127, Bonn, Germany.

Adelina Orellana (A)

Research Center and Memory Clinic, Ace Alzheimer Center Barcelona, Universitat Internacional de Catalunya, Barcelona, Spain.
CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.

Lene Pålhaugen (L)

Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
Department of Neurology, Akershus University Hospital, Lorenskog, Norway.

Janne M Papma (JM)

Department of Neurology and Alzheimer Center Erasmus MC, Erasmus MC University Medical Center, Rotterdam, The Netherlands.

Florence Pasquier (F)

Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1167 - RID-AGE / Labex DISTALZ - Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement, F-59000, Lille, France.
ORCID: 0000-0001-9880-9788

Robert Perneczky (R)

German Center for Neurodegenerative Diseases (DZNE, Munich), Munich, Germany.
Department of Psychiatry and Psychotherapy, University Hospital, LMU Munich, Munich, Germany.
Munich Cluster for Systems Neurology (SyNergy) Munich, Munich, Germany.
Ageing Epidemiology Research Unit, School of Public Health, Imperial College London, London, UK.

Oliver Peters (O)

German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany.
German Center for Neurodegenerative Diseases (DZNE), Berlin, Germany.

Yolande A L Pijnenburg (YAL)

Alzheimer Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC Location VUmc, Amsterdam, The Netherlands.
Amsterdam Neuroscience, Neurodegeneration, Amsterdam, The Netherlands.

Julius Popp (J)

Department of Geriatric Psychiatry, University Hospital of Psychiatry Zürich and University of Zürich, Zurich, Switzerland.
Old Age Psychiatry, Department of Psychiatry, University Hospital of Lausanne, Lausanne, Switzerland.
ORCID: 0000-0002-0068-0312

Danielle Posthuma (D)

Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, VU Amsterdam, Amsterdam, The Netherlands.

Ana Pozueta (A)

Cognitive Impairment Unit, Neurology Service, "Marqués de Valdecilla" University Hospital, Institute for Research "Marques de Valdecilla" (IDIVAL), University of Cantabria, Santander, Spain, and Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain.

Josef Priller (J)

German Center for Neurodegenerative Diseases (DZNE), Berlin, Germany.
Department of Psychiatry and Psychotherapy, Charité, Charitéplatz 1, 10117, Berlin, Germany.
Department of Psychiatry and Psychotherapy, Klinikum rechts der isar, Technical University Munich, 81675, Munich, Germany.

Raquel Puerta (R)

Research Center and Memory Clinic, Ace Alzheimer Center Barcelona, Universitat Internacional de Catalunya, Barcelona, Spain.

Inés Quintela (I)

Grupo de Medicina Xenómica, Centro Nacional de Genotipado (CEGEN-PRB3-ISCIII), Universidade de Santiago de Compostela, Santiago de Compostela, Spain.
ORCID: 0000-0002-0239-7975

Inez Ramakers (I)

Department of Psychiatry and Neuropsychologie, Alzheimer Center Limburg, Maastricht University, Maastricht, The Netherlands.

Eloy Rodriguez-Rodriguez (E)

Cognitive Impairment Unit, Neurology Service, "Marqués de Valdecilla" University Hospital, Institute for Research "Marques de Valdecilla" (IDIVAL), University of Cantabria, Santander, Spain, and Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain.
ORCID: 0000-0001-7742-677X

Dan Rujescu (D)

Division of General Psychiatry, Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria.

Ingvild Saltvedt (I)

Department of Neuromedicine and Movement Science, Norwegian University of Science and Technology (NTNU), Trondheim, Norway.
Department of Geriatrics, St Olav Hospital, University Hospital of Trondheim, Trondheim, Norway.

Pascual Sanchez-Juan (P)

Alzheimer's Centre Reina Sofia-CIEN Foundation-ISCIII, 28031, Madrid, Spain.
ORCID: 0000-0002-6081-8037

Philip Scheltens (P)

Alzheimer Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC Location VUmc, Amsterdam, The Netherlands.
Amsterdam Neuroscience, Neurodegeneration, Amsterdam, The Netherlands.

Norbert Scherbaum (N)

Department of Psychiatry and Psychotherapy, Medical Faculty, LVR-Hospital Essen, University of Duisburg-Essen, Essen, Germany.

Matthias Schmid (M)

Institute of Medical Biometry, Informatics and Epidemiology, University Hospital of Bonn, Bonn, Germany.

Anja Schneider (A)

Department of Neurodegenerative Diseases and Geriatric Psychiatry, University Hospital Bonn, Medical Faculty, Bonn, Germany.
German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.

Geir Selbæk (G)

Norwegian National Centre for Ageing and Health, Vestfold Hospital Trust, Tønsberg, Norway.
Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
Department of Geriatric Medicine, Oslo University Hospital, Oslo, Norway.
ORCID: 0000-0001-6511-8219

Per Selnes (P)

Department of Neurology, Akershus University Hospital, Lorenskog, Norway.

Alexey Shadrin (A)

NORMENT Centre, Institute of Clinical Medicine, University of Oslo and Division of Mental Health, Oslo, Norway.

Ingmar Skoog (I)

Neuropsychiatric Epidemiology Unit, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, Centre for Ageing and Health (AGECAP) at the University of Gothenburg, Gothenburg, Sweden.
Region Västra Götaland, Sahlgrenska University Hospital, Psychiatry, Cognition and Old Age Psychiatry Clinic, Gothenburg, Sweden.

Hilkka Soininen (H)

Department of Neurology, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland.

Lluís Tárraga (L)

Research Center and Memory Clinic, Ace Alzheimer Center Barcelona, Universitat Internacional de Catalunya, Barcelona, Spain.
CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.

Stefan Teipel (S)

German Center for Neurodegenerative Diseases (DZNE), Rostock, Germany.
Department of Psychosomatic Medicine, Rostock University Medical Center, Gehlsheimer Str. 20, 18147, Rostock, Germany.

Betty Tijms (B)

Alzheimer Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC Location VUmc, Amsterdam, The Netherlands.
Amsterdam Neuroscience, Neurodegeneration, Amsterdam, The Netherlands.
ORCID: 0000-0002-2612-1797

Magda Tsolaki (M)

1st Department of Neurology, School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, Thessaloniki, Makedonia, Greece.

Christine Van Broeckhoven (C)

Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium.
Neurodegenerative Brain Diseases Group, VIB Center for Molecular Neurology, VIB, Antwerp, Belgium.

Jasper Van Dongen (J)

Complex Genetics of Alzheimer's Disease Group, VIB Center for Molecular Neurology, VIB, Antwerp, Belgium.
Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium.
ORCID: 0000-0001-5599-0046

John C van Swieten (JC)

Department of Neurology and Alzheimer Center Erasmus MC, Erasmus MC University Medical Center, Rotterdam, The Netherlands.

Rik Vandenberghe (R)

Neurology, University Hospitals Leuven, Leuven, Belgium.
Laboratory for Cognitive Neurology, Department of Neurosciences, Leuven Brain Institute, Leuven, Belgium.

Jean-Sébastien Vidal (JS)

Université Paris Cité, EA4468, Maladie d'Alzheimer, F-75013 Paris, France.

Pieter J Visser (PJ)

Alzheimer Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC Location VUmc, Amsterdam, The Netherlands.
Amsterdam Neuroscience, Neurodegeneration, Amsterdam, The Netherlands.
Alzheimer Center Limburg, School for Mental Health and Neuroscience Maastricht University, Maastricht, The Netherlands.
Department of Neurobiology, Care Sciences and Society, Division of Neurogeriatrics Karolinska Institutet, Stockholm, Sweden.

Jonathan Vogelgsang (J)

Department of Psychiatry and Psychotherapy, University Medical Center Goettingen, Göttingen, Germany.
Department of Psychiatry, Harvard Medical School, McLean Hospital, Belmont, MA, USA.

Margda Waern (M)

Neuropsychiatric Epidemiology Unit, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, Centre for Ageing and Health (AGECAP) at the University of Gothenburg, Gothenburg, Sweden.
Region Västra Götaland, Sahlgrenska University Hospital, Psychiatry, Psychosis Clinic, Gothenburg, Sweden.
ORCID: 0000-0002-8330-6915

Michael Wagner (M)

Department of Neurodegenerative Diseases and Geriatric Psychiatry, University Hospital Bonn, Medical Faculty, Bonn, Germany.
German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.
ORCID: 0000-0003-2589-6440

Jens Wiltfang (J)

Department of Psychiatry and Psychotherapy, University Medical Center Goettingen, Göttingen, Germany.
German Center for Neurodegenerative Diseases (DZNE), Göttingen, Germany.
Medical Science Department, iBiMED, Aveiro, Portugal.

Mandy M J Wittens (MMJ)

Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium.
Center for Neurosciences (C4N), Vrije Universiteit Brussel, Brussels, Belgium.

Henrik Zetterberg (H)

Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.
Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden.
Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK.
UK Dementia Research Institute at UCL, London, UK.
Hong Kong Center for Neurodegenerative Diseases, Hong Kong, China.
ORCID: 0000-0003-3930-4354

Miren Zulaica (M)

CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.
Hospital Universitario Donostia-OSAKIDETZA, Donostia, Spain.
Instituto Biodonostia, San Sebastián, Spain.

Cornelia M van Duijn (CM)

Department of Epidemiology, ErasmusMC, Rotterdam, The Netherlands.
Nuffield Department of Population Health, Oxford University, Oxford, UK.
ORCID: 0000-0002-2374-9204

Maria Bjerke (M)

Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium.
Center for Neurosciences (C4N), Vrije Universiteit Brussel, Brussels, Belgium.
Laboratory of Neurochemistry, Universitair Ziekenhuis Brussel, Brussels, Belgium.

Sebastiaan Engelborghs (S)

Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium.
Center for Neurosciences (C4N), Vrije Universiteit Brussel, Brussels, Belgium.
Laboratory of Neurochemistry, Universitair Ziekenhuis Brussel, Brussels, Belgium.
Department of Neurology, Universitair Ziekenhuis Brussel, Brussels, Belgium.
ORCID: 0000-0003-0304-9785

Frank Jessen (F)

German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.
Department of Psychiatry and Psychotherapy, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
Cluster of Excellence Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany.

Charlotte E Teunissen (CE)

Amsterdam Neuroscience, Neurodegeneration, Amsterdam, The Netherlands.
Neurochemistry Lab, Department of Clinical Chemistry, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands.

Pau Pastor (P)

Unit of Neurodegenerative diseases, Department of Neurology, University Hospital Germans Trias i Pujol and The Germans Trias i Pujol Research Institute (IGTP) Badalona, Barcelona, Spain.

Mikko Hiltunen (M)

Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland.

Martin Ingelsson (M)

Department of Public Health and Caring Sciences, Molecular Geriatrics, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden.
Krembil Brain Institute, University Health Network, Toronto, Ontario, Canada.
Department of Medicine and Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Canada.

Ole A Andreassen (OA)

NORMENT Centre, Institute of Clinical Medicine, University of Oslo and Division of Mental Health, Oslo, Norway.
Addiction, Oslo University Hospital, 0407, Oslo, Norway.
ORCID: 0000-0002-4461-3568

Jordi Clarimón (J)

CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.
Sant Pau Memory Unit, Department of Neurology, Institut d'Investigacions Biomèdiques Sant Pau - Hospital de Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain.

Kristel Sleegers (K)

Complex Genetics of Alzheimer's Disease Group, VIB Center for Molecular Neurology, VIB, Antwerp, Belgium.
Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium.
ORCID: 0000-0002-0283-2332

Agustín Ruiz (A)

Research Center and Memory Clinic, Ace Alzheimer Center Barcelona, Universitat Internacional de Catalunya, Barcelona, Spain.
CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.

Alfredo Ramirez (A)

Division of Neurogenetics and Molecular Psychiatry, Department of Psychiatry and Psychotherapy, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
Department of Neurodegenerative Diseases and Geriatric Psychiatry, University Hospital Bonn, Medical Faculty, Bonn, Germany.
German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.
Cluster of Excellence Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany.
Department of Psychiatry, Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, San Antonio, TX, USA.
ORCID: 0000-0003-4991-763X

Carlos Cruchaga (C)

Department of Psychiatry, Washington University School of Medicine, St Louis, MO, USA.
NeuroGenomics and Informatics, Washington University School of Medicine, St Louis, MO, USA.
Hope Center for Neurological Disorders, Washington University School of Medicine, St Louis, MO, USA.
ORCID: 0000-0002-0276-2899

Jean-Charles Lambert (JC)

Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1167 - RID-AGE / Labex DISTALZ - Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement, F-59000, Lille, France.

Wiesje van der Flier (W)

Alzheimer Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC Location VUmc, Amsterdam, The Netherlands. wm.vdflier@amsterdamumc.nl.
Amsterdam Neuroscience, Neurodegeneration, Amsterdam, The Netherlands. wm.vdflier@amsterdamumc.nl.
ORCID: 0000-0001-8766-6224

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Classifications MeSH

questionsmedicales.fr › Troubles mentaux › Troubles neurocognitifs › Démence › Maladie d'Alzheimer › Genome-wide meta-analysis for Alzheimer's...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Peptides bêta-amyloïdes › Genome-wide meta-analysis for Alzheimer's...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Lipoprotéines › Apolipoprotéines › Apolipoprotéines E › Genome-wide meta-analysis for Alzheimer's...
questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Genome-wide meta-analysis for Alzheimer's...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines du cycle cellulaire › Genome-wide meta-analysis for Alzheimer's...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Genome-wide meta-analysis for Alzheimer's...
questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › Fragments peptidiques › Genome-wide meta-analysis for Alzheimer's...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de tissu nerveux › Protéines associées aux microtubules › Protéines tau › Genome-wide meta-analysis for Alzheimer's...