Prognostic Value of Lymph Node Yield, Lymph Node Density, and pN in Oral Cancer.
lymph node density
lymph node yield
oral squamous cell carcinoma
pN
prognostic value
Journal
Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery
ISSN: 1097-6817
Titre abrégé: Otolaryngol Head Neck Surg
Pays: England
ID NLM: 8508176
Informations de publication
Date de publication:
08 2023
08 2023
Historique:
received:
02
06
2022
accepted:
07
08
2022
medline:
23
10
2023
pubmed:
7
9
2022
entrez:
6
9
2022
Statut:
ppublish
Résumé
To investigate thresholds for lymph node yield (LNY), lymph node density (LND), and pN in patients with oral squamous cell carcinoma in relation to previous findings in the literature. Retrospective register-based study. Copenhagen Oral Cavity Squamous Cell Carcinoma database. Appropriate thresholds for LNY, LND, and pN were determined by areas under the curve and subsequently subjected to multivariate analysis. Five-year overall survival and 3-year recurrence-free survival were determined by Kaplan-Meier survival curves. In total, 413 patients diagnosed with oral squamous cell carcinoma were included. In the pN0 cohort, no superior/prognostic LNY cutoff values were detected. In the pN+ cohort, areas under the curve determined thresholds of LNY, LND, and pN to be 21 nodes, 5%, and 3 metastases, respectively. The 5-year overall survival was 52% for patients with LNY ≥21 vs 38% for patients with LNY <21 (hazard ratio [HR], 1.49; 95% CI, 1.05-2.11; P < .05), 60% for patients with LND ≤5% vs 38% for patients with LND >6% (HR, 1.63; 95% CI, 1.03-2.57; P < .05), and 43% for patients with pN <3 vs 26% for patients with pN ≥3 (HR, 1.40; 95% CI, 1.04-2.15; P < .05). Increased nodal yield, decreased LND, and decreasing number of pN were associated with significantly improved survival outcomes. LNY might serve as a prognosticator of survival as well as a surgical quality indicator. LND may have implications as a tool in cancer staging and treatment planning.
Identifiants
pubmed: 36066971
doi: 10.1177/01945998221123927
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
276-285Informations de copyright
© 2022 American Academy of Otolaryngology-Head and Neck Surgery Foundation.
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